Results 91 to 100 of about 1,115 (165)
Recent advances in pharmaceutical cocrystals of theophylline
Natural Products and BioprospectingAbstractCurrently, cocrystallization is a promising strategy for tailoring the physicochemical properties of active pharmaceutical ingredients. Theophylline, an alkaloid and the most primary metabolite of caffeine, is a readily available compound found in tea and coffee.
Yanxiao Jia +7 more
openaire +3 more sources
Preparation of cocrystal-in-excipient systems by advanced pharmaceutical methods
, 2019 This thesis focuses on the production of cocrystal-in-excipient systems by a variety of advanced pharmaceutical methods, such as spray drying, hot melt extrusion and spray coating.
WALSH, DAVID
core
, 2016 Engineered cocrystals offer an alternative solid drug form with tailored physicochemical properties. Interestingly, although cocrystals provide many new possibilities, they also present new challenges, particularly in regard to their design and large ...
Jones, David S. +5 more
core +1 more source
Engineering cocrystal solubility, stability, and pH max by micellar solubilization [PDF]
, 2011 Cocrystals offer great promise in enhancing drug aqueous solubilities, but face the challenge of conversion to a less soluble drug when in contact with solvent.
Naír Rodríguez‐Hornedo +3 more
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Dissolution rate of ciprofloxacin and its cocrystal with resorcinol
ADMET and DMPK, 2018 The synthesis of cocrystals is presented as an alternative to improve the properties of active pharmaceutical ingredients, especially those related to solubility and dissolution rate.
Clara Ràfols +5 more
doaj +1 more source
, 2023 Cocrystal engineering has gained tremendous popularity in the past decade thanks to its capability in modifying the pharmaceutical properties of drugs, including solubility, dissolution rate, stability, etc.
Si Nga Wong (9068819)
core +1 more source
, 2021 The present study aimed to investigate how cocrystal solution-state stability may affect the polymorphic drug formation and transition during dissolution.
Lakerveld, R +7 more
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Structure of the caffeine-pyrogallol complex:revisiting a pioneering structural analysis of a model pharmaceutical cocrystal [PDF]
The 1967 attempt of structural analysis of the solid-state complex of caffeine and pyrogallol was a pioneering structural investigation in the supramolecular chemistry of caffeine, of what today would easily be considered an archetype of a model ...
Lennox, Cameron B. +4 more
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CrystalsParacetamol-4,4′-bipyridine cocrystals were synthesized using a solution method, reflux method, grinding method, and ultrasonic method. The structures and properties were characterized through the utilization of single-crystal X-ray diffraction (SXRD ...
Xiaoming Zhang +4 more
doaj +1 more source
Chloral Hydrate Polymorphs and Cocrystal Revisited: Solving Two Pharmaceutical Cold Cases
, 2016 Chloral hydrate has the distinction of perhaps being the first reported example of a pharmaceutical compound to exhibit polymorphism (1877) and the first use of a pharmaceutical cocrystal in a drug product (Beta-Chlor, 1960s).
Miranda L. Perry (1662487) +2 more
core +1 more source