Results 101 to 110 of about 1,115 (165)

Role of Lattice Disorder in Water-Mediated Dissociation of Pharmaceutical Cocrystal Systems

, 2019
Our objective is to mechanistically understand the implications of processing-induced lattice disorder on  the stability of pharmaceutical cocrystals. Caffeine–oxalic acid (CAFOXA) and dicalcium phosphate anhydrate (DCPA) were the model cocrystal (drug ...
Naga Kiran Duggirala (1662493), Raj Suryanarayanan (1246851), Navpreet Kaur, Raj Suryanarayanan, Seema Thakral (6791825), Naga Kiran Duggirala, Seema Thakral, Navpreet Kaur (3162048)   +7 more
core   +1 more source

Salt Cocrystallization—A Method to Improve Solubility and Bioavailability of Dihydromyricetin

Pharmaceutics
Objectives: This study aimed to find salts with similar pharmacological effects designed as cocrystals to improve the aqueous solubility and bioavailability of dihydromyricetin (DMY).
Jingping Li, Xinke Chen, Yanan Liu, Caiwu Jiang   +3 more
doaj   +1 more source

A Review on Pharmaceutical Cocrystals [PDF]

International Journal for Pharmaceutical Research Scholars, 2018
A. S. Athira, S. Anu, S. R. Seeja, M. S. Thaifa   +3 more
openaire   +1 more source

Influence of Coformer Stoichiometric Ratio on Pharmaceutical Cocrystal Dissolution: Three Cocrystals of Carbamazepine/4-Aminobenzoic Acid

, 2016
Cocrystallization is a technique to optimize solid forms that shows great potential to improve the solubility of active pharmaceutical ingredients (APIs).
Zi Li (223785), Adam J. Matzger (1326309)   +1 more
core   +1 more source

Probenecid and benzamide: cocrystal prepared by a green method and its physico-chemical and pharmaceutical characterization

, 2020
The eco-friendly method of kneading was here used to synthesize a cocrystal of probenecid, an uricosuric drug used in treating gout and hyperuricemia, with the aim to improve its pharmaceutical behavior.
Friuli V., Ferrara C., Milanese C., Mustarelli P., Girella A., Berbenni V., Maggi L., Monteforte F., Bruni G., Capsoni D., Marini A.   +10 more
core   +1 more source

A Novel Cocrystal of Daidzein with Piperazine to Optimize the Solubility, Permeability and Bioavailability of Daidzein

Molecules
It is well known that daidzein has various significant medicinal values and health benefits, such as anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, cholesterol lowering, neuroprotective, cardioprotective and so on.
Zhipeng Wang, Shuang Li, Qi Li, Wenwen Wang, Meiru Liu, Shiying Yang, Li Zhang, Dezhi Yang, Guanhua Du, Yang Lu   +9 more
doaj   +1 more source

Cocrystallization and Particle Size Reduction of Active Pharmaceutical Ingredients (APIs) Using Supercritical Carbon Dioxide Crystallization or Spray Drying

Modern active pharmaceutical ingredients (APIs) often exhibit poor aqueous solubility, leading to poor bioavailability. Methods to improve dissolution include altering solid form (salts, polymorphs, cocrystals), creating amorphous dispersions, and ...
MacEachern, Lauren
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Organic anion lithium ionic cocrystal compounds and compositions

, 2019
A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates,
Shytle, Roland Douglas, Duggirala, Naga, Zaworotko, Michael John, Smith, Adam John   +3 more
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In Silico Coformer Screening for Mefenamic Acid Cocrystallization

Jurnal Info Kesehatan
Cocrystallization is a widely used approach to enhance the solubility and dissolution characteristics of poorly soluble drugs. A pharmaceutical cocrystal is a multicomponent system composed of a solid active pharmaceutical ingredient (API) and a coformer,
Aulia Fikri Hidayat, Taufik Muhammad Fakih, Gita Cahya Eka Darma, Ratu Choesrina   +3 more
doaj   +1 more source

Pharmaceutical Cocrystal Eutectic Analysis: Study of Thermodynamic Stability, Solubility, and Phase Behavior [PDF]

, 2010
Cocrystals are an emerging solid-state form to change physicochemical and biopharmaceutical drug properties. This dissertation focuses on the thermodynamic stability and solubility of pharmaceutical cocrystals.
Good, David John
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