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Cocrystal: A Review on the Design and Preparation of Pharmaceutical Cocrystals
Asian Journal of Research in Pharmaceutical Sciences, 2023The majority of the active pharmaceutical components have issues with poor solubility, bioavailability, chemical stability, and moisture absorption. Pharmaceutical crystals are a reliable way to change the aforementioned physicochemical properties of drugs without changing their pharmacological behaviour.
Tanmay Jit +4 more
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Pharmaceutical Cocrystal: An Antique and Multifaceted Approach
Current Drug Delivery, 2017Pharmaceutical cocrystal is an emerging approach to tailor physicochemical and mechanical properties of drug substances. Cocrystals are composed of API and pharmaceutically acceptable coformer. It is used to address the solubility, dissolution, mechanical properties and stability of drugs.This review discusses introduction to cocrystal, preparation ...
Prabhakar Panzade
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Pharmaceutical cocrystals: An overview
International Journal of Pharmaceutics, 2011Pharmaceutical cocrystals are emerging as a new class of solid drugs with improved physicochemical properties, which has attracted increased interests from both industrial and academic researchers. In this paper a brief and systematic overview of pharmaceutical cocrystals is provided, with particular focus on cocrystal design strategies, formation ...
Qiao, N. +5 more
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The role of cocrystals in pharmaceutical science
Drug Discovery Today, 2008Pharmaceutical cocrystals, a subset of a long known but little-studied class of compounds, represent an emerging class of crystal forms in the context of pharmaceutical science. They are attractive to pharmaceutical scientists because they can significantly diversify the number of crystal forms that exist for a particular active pharmaceutical ...
Ning, Shan, Michael J, Zaworotko
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Pharmaceutical cocrystals: walking the talk
Chemical Communications, 2016From Saridon to Entresto: the journey of pharmaceuticals from the first drug–drug combination of propyphenazone and pyrithyldione in 1937 (left) to the most recent monosodium sacubitril and disodium valsartan in 2015 (right).
Geetha, Bolla, Ashwini, Nangia
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Pharmaceutical Cocrystals of Niclosamide
Crystal Growth & Design, 2012Niclosamide (NCL) is an anthelmintic BCS class II drug of low solubility and high permeability. Pharmaceutical cocrystals of NCL were prepared with GRAS molecules, such as caffeine (CAF), urea (URE), p-aminobenzoic acid (PABA), theophylline (THPH), nicotinamide (NCT), and isonicotinamide (INA), to improve drug solubility. Neat grinding, wet granulation,
Palash Sanphui +2 more
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Pharmaceutical cocrystals and poorly soluble drugs
International Journal of Pharmaceutics, 2013In recent years cocrystal formation has emerged as a viable strategy towards improving the solubility and bioavailability of poorly soluble drugs. In this review the success of numerous pharmaceutical cocrystals for the improvement of the solubility and dissolution rates of poorly soluble drugs is demonstrated using various examples taken from the ...
Ranjit, Thakuria +5 more
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Pharmaceutical Cocrystals of Diflunisal and Diclofenac with Theophylline
Molecular Pharmaceutics, 2014Pharmaceutical cocrystals of nonsteroidal anti-inflammatory drugs diflunisal (DIF) and diclofenac (DIC) with theophylline (THP) were obtained, and their crystal structures were determined. In both of the crystal structures, molecules form a hydrogen bonded supramolecular unit consisting of a centrosymmetric dimer of THP and two molecules of active ...
Artem O. Surov +6 more
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Recent Advances on the Biological Study of Pharmaceutical Cocrystals
AAPS PharmSciTech, 2022As a low-risk, low-cost, but high-reward route, cocrystallization of drugs with appropriate coformers is applied to improve the physiochemical and biopharmaceutical properties of drugs. Currently, most researchers concentrate their efforts on the preparation, characterization, and improvement of physicochemical properties of pharmaceutical cocrystals ...
Zhipeng, Wang +5 more
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Challenges in Translational Development of Pharmaceutical Cocrystals
Journal of Pharmaceutical Sciences, 2017The last 2 decades have witnessed increased research in the area of cocrystals resulting in deeper scientific understanding, increase in intellectual property landscape, and evolution in the regulatory environment. Pharmaceutical cocrystals have received significant attention as a new solid form on account of their ability to modulate poor ...
Dnyaneshwar P, Kale +2 more
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