Results 131 to 140 of about 2,679 (172)
Some of the next articles are maybe not open access.
Pharmaceutical cocrystals: walking the talk
Chemical Communications, 2016From Saridon to Entresto: the journey of pharmaceuticals from the first drug–drug combination of propyphenazone and pyrithyldione in 1937 (left) to the most recent monosodium sacubitril and disodium valsartan in 2015 (right).
Geetha, Bolla, Ashwini, Nangia
openaire +2 more sources
Pharmaceutical Cocrystals of Niclosamide
Crystal Growth & Design, 2012Niclosamide (NCL) is an anthelmintic BCS class II drug of low solubility and high permeability. Pharmaceutical cocrystals of NCL were prepared with GRAS molecules, such as caffeine (CAF), urea (URE), p-aminobenzoic acid (PABA), theophylline (THPH), nicotinamide (NCT), and isonicotinamide (INA), to improve drug solubility. Neat grinding, wet granulation,
Palash Sanphui +2 more
openaire +1 more source
Pharmaceutical cocrystals and poorly soluble drugs
International Journal of Pharmaceutics, 2013In recent years cocrystal formation has emerged as a viable strategy towards improving the solubility and bioavailability of poorly soluble drugs. In this review the success of numerous pharmaceutical cocrystals for the improvement of the solubility and dissolution rates of poorly soluble drugs is demonstrated using various examples taken from the ...
Ranjit, Thakuria +5 more
openaire +2 more sources
Pharmaceutical Cocrystals of Diflunisal and Diclofenac with Theophylline
Molecular Pharmaceutics, 2014Pharmaceutical cocrystals of nonsteroidal anti-inflammatory drugs diflunisal (DIF) and diclofenac (DIC) with theophylline (THP) were obtained, and their crystal structures were determined. In both of the crystal structures, molecules form a hydrogen bonded supramolecular unit consisting of a centrosymmetric dimer of THP and two molecules of active ...
Artem O. Surov +6 more
openaire +2 more sources
2017
The aim of this project is to improve cocrystal screening and solubility prediction methods.
openaire +1 more source
The aim of this project is to improve cocrystal screening and solubility prediction methods.
openaire +1 more source
Recent Advances on the Biological Study of Pharmaceutical Cocrystals
AAPS PharmSciTech, 2022As a low-risk, low-cost, but high-reward route, cocrystallization of drugs with appropriate coformers is applied to improve the physiochemical and biopharmaceutical properties of drugs. Currently, most researchers concentrate their efforts on the preparation, characterization, and improvement of physicochemical properties of pharmaceutical cocrystals ...
Zhipeng, Wang +5 more
openaire +2 more sources
Challenges in Translational Development of Pharmaceutical Cocrystals
Journal of Pharmaceutical Sciences, 2017The last 2 decades have witnessed increased research in the area of cocrystals resulting in deeper scientific understanding, increase in intellectual property landscape, and evolution in the regulatory environment. Pharmaceutical cocrystals have received significant attention as a new solid form on account of their ability to modulate poor ...
Dnyaneshwar P, Kale +2 more
openaire +2 more sources
Multicomponent pharmaceutical cocrystals: furosemide and pentoxifylline
Acta Crystallographica Section C Crystal Structure Communications, 2012The combination of the active pharmaceutical ingredients furosemide [4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid] and pentoxifylline [3,7-dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione] produces a 1:1 cocrystal, C12H11ClN2O5S·C13H18N4O3, (I), a 1:1 cocrystal hydrate, C12H11ClN2O5S·C13H18N4O3·H2O, (II), and a 1:1 cocrystal ...
Dmitrijs, Stepanovs, Anatoly, Mishnev
openaire +2 more sources
International Journal of Pharmaceutics, 2012
Cocrystals (CCs) used in the pharmaceutical industry are defined as complex crystals formed by reaction between an API and a cocrystal former (CCF); unlike salts, CCs do not show proton transfer. Recently, pharmaceutical CCs have been used to improve the drug-likeness of APIs, such as solubility and stability.
Katsuhiko, Yamamoto +2 more
openaire +2 more sources
Cocrystals (CCs) used in the pharmaceutical industry are defined as complex crystals formed by reaction between an API and a cocrystal former (CCF); unlike salts, CCs do not show proton transfer. Recently, pharmaceutical CCs have been used to improve the drug-likeness of APIs, such as solubility and stability.
Katsuhiko, Yamamoto +2 more
openaire +2 more sources
Pharmaceutical Cocrystal and Salts of Norfloxacin
Crystal Growth & Design, 2006The aim of this study was to investigate the structural and pharmaceutical properties of norfloxacin (a poorly soluble antibacterial drug), its cocrystal, and salts. Norfloxacin in the anhydrous form (form A, 1) was crystallized. It was cocrystallized with isonicotinamide (2), and organic salts were prepared with succinic acid, malonic acid, and maleic
Srinivas Basavoju +2 more
openaire +1 more source