Results 131 to 140 of about 1,115 (165)
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Changes in the proportions of an active pharmaceutical through cocrystals
Drug Development Research, 2021AbstractIn this study, the modulation of amounts sulfathiazolium cations in different 2,6‐pyridinedicarboxylates is demonstrated. An uncommon monoionic sulfathiazolium zinc 2,6‐pyridinedicarboxylate (1:1 electrolyte) complex was characterized. Conventional sulfathiazolium zinc‐bis‐2,6‐pyridinedicarboxylate dianionic complexes (2:1 electrolyte) were ...
Abhay Pratap Singh +2 more
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2017
The aim of this project is to improve cocrystal screening and solubility prediction methods.
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The aim of this project is to improve cocrystal screening and solubility prediction methods.
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Multicomponent pharmaceutical cocrystals: furosemide and pentoxifylline
Acta Crystallographica Section C Crystal Structure Communications, 2012The combination of the active pharmaceutical ingredients furosemide [4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid] and pentoxifylline [3,7-dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione] produces a 1:1 cocrystal, C12H11ClN2O5S·C13H18N4O3, (I), a 1:1 cocrystal hydrate, C12H11ClN2O5S·C13H18N4O3·H2O, (II), and a 1:1 cocrystal ...
Dmitrijs, Stepanovs, Anatoly, Mishnev
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Pharmaceutical Cocrystals of Famotidine: Structural and Biopharmaceutical Evaluation
Journal of Pharmaceutical Sciences, 2022Famotidine (FMT) an anti-ulcer drug, recently being repurposed in COVID-19 treatment, suffers from poor aqueous solubility and restricted bioavailability (
Akshita Jindal +6 more
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International Journal of Pharmaceutics, 2012
Cocrystals (CCs) used in the pharmaceutical industry are defined as complex crystals formed by reaction between an API and a cocrystal former (CCF); unlike salts, CCs do not show proton transfer. Recently, pharmaceutical CCs have been used to improve the drug-likeness of APIs, such as solubility and stability.
Katsuhiko, Yamamoto +2 more
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Cocrystals (CCs) used in the pharmaceutical industry are defined as complex crystals formed by reaction between an API and a cocrystal former (CCF); unlike salts, CCs do not show proton transfer. Recently, pharmaceutical CCs have been used to improve the drug-likeness of APIs, such as solubility and stability.
Katsuhiko, Yamamoto +2 more
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ChemInform Abstract: Pharmaceutical Cocrystals
ChemInform, 2011AbstractReview: 98 refs.
Ning Qiao +5 more
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Solubility Advantage of Pharmaceutical Cocrystals
Crystal Growth & Design, 2009Pharmaceutical cocrystals can improve solubility, dissolution, and bioavailability of poorly water soluble drugs. However, true cocrystal solubility is not readily measured for highly soluble cocrystals because they can transform to the most stable drug form in solution.
David J. Good, Naír Rodríguez-Hornedo
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Impact of pharmaceutical cocrystals: the effects on drug pharmacokinetics
Expert Opinion on Drug Metabolism & Toxicology, 2014Pharmaceutical cocrystallization has emerged in the past decade as a new strategy to enhance the clinical performance of orally administered drugs. A pharmaceutical cocrystal is a multi-component crystalline material in which the active pharmaceutical ingredient is in a stoichiometric ratio with a second compound that is generally a solid under ambient
Ning, Shan +3 more
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Pharmaceutical cocrystals: along the path to improved medicines
Chemical Communications, 2016Cocrystals, a long known but understudied class of crystalline solids, have attracted interest from crystal engineers and pharmaceutical scientists in the past decade and are now an integral part of the preformulation stage of drug development.
Naga K, Duggirala +3 more
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Cocrystal Systems of Pharmaceutical Interest: 2009
2011As scientists become more aware of a substantial expansion in the scope of solid-state structural variations that can be obtained through the cocrystallization of several molecules in a single lattice structure, studies of the mixed molecular crystal systems known as cocrystals have mushroomed. Along these lines, workers have researched the assembly of
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