Results 111 to 120 of about 1,115 (165)

Solid-state vibrational circular dichroism for pharmaceutical applications: polymorphs and cocrystal of sofosbuvir

X-ray diffraction is a commonly used technique in the pharmaceutical industry for the determination of the atomic and molecular structure of crystals.
Adam , Sklenář, Miroslav , Šoóš, Věra, Schrenková, Lucie , Růžičková, Lucie , Bednárová, Eliška , Skořepová, Jakub, Kaminsky, Markéta , Pazderková, Argyro , Chatziadi   +8 more
core   +1 more source

Advances in Quantitative Analytical Methods for Solid Drugs

Crystals
The solid form of the drug can directly affect the physicochemical properties, bioavailability, safety, and efficacy of the drug, and its types mainly include amorphous state, single-component polycrystalline, hydrate, solvate, salt, and cocrystal ...
Yue Tao, Yuhan Gao, Baoxi Zhang, Kun Hu, Yifei Xie, Li Zhang, Shiying Yang, Yang Lu   +7 more
doaj   +1 more source

Control of Pharmaceutical Cocrystal Polymorphism on Various Scales by Mechanochemistry: Transfer from the Laboratory Batch- to the Large-Scale Extrusion Processing

, 2018
We demonstrate a controllable mechanochemical synthesis of cocrystal polymorphs of ascorbic acid (vitamin C) and nicotinamide (vitamin B3) on different scales and without using bulk solvents.
Tomislav, Stolar, Irena, Kereković, Stipe, Lukin, Martina, Tireli, Gordana, Matijašić, Krunoslav, Užarević, Ivan, Halasz, Zvonimir, Katančić, Igor, Dejanović, Irena, Sović, Bahar, Karadeniz, Matija, Gretić, Marco, Di Michiel   +12 more
core   +1 more source

DEVELOPMENT OF COSMETIC CREAM CONTAINING A PHARMACEUTICAL COCRYSTAL OF SALICYLIC AND PHENYLALANINE

, 2019
Objective: The objective of this present work was to develop the chemical peeling cream containing the synthesized active ingredient pharmaceutical cocrystal of salicylic acid and phenylalanine.
SAWATDEE, SOMCHAI, PHETMUNG, HIRIHATTAYA
core  

Structure determination of the theophylline-nicotinamide cocrystal: a combined powder XRD, 1D solid-state NMR, and theoretical calculation study

, 2014
The crystal structure of a powder pharmaceutical cocrystal, theophylline-nicotinamide (1 : 1) crystal complex, is determined for the first time by using a combination of X-ray powder diffraction (XRPD), 1D solid state NMR, as well as density functional ...
Wenslow, RM (Wenslow, Robert M., Jr.), Yu, KC (Yu, Kaichao), Zhang, HL (张海禄), Chu, YY (Chu, Yueying), Wang, L (Wang, Lin), Li, P (Li, Ping), Deng, ZW (邓宗武)   +6 more
core  

COCRYSTAL OF ATORVASTATIN CALCIUM – MALONIC ACID

, 2017
Proceeding 1st International Conference on Medicine and Health Sciences (ICMHS) 2016Cocrystal is a relatively new solid form of active pharmaceutical ingredient that offers an alternative platform in improving physicochemical properties of active ...
Wicaksono, Yudi, Wisudyaningsih, Budipratiwi, Siswoyo, Tri Agus   +2 more
core  

Evaluating experimental, knowledge-based and computational cocrystal screening methods to advance drug-drug cocrystal fixed-dose combination development

Fixed-dose combinations (FDCs) offer significant advantages to patients and the pharmaceutical industry alike through improved dissolution profiles, synergistic effects and extended patent lifetimes.
Alice Parkes (17281864), Emmet O'Reilly (12348763), Ahmad Ziaee (12349234)   +2 more
core   +1 more source

Norfloxacin saccharinate–saccharin dihydrate cocrystal – A new pharmaceutical cocrystal with an organic counter ion

Journal of Molecular Structure, 2008
A novel pharmaceutical cocrystal was obtained with an organic counter ion. Norfloxacin saccharinate dihydrate and its cocrystal, norfloxacin saccharinate-saccharin dihydrate, were crystallized. (C) 2008 Elsevier B.V. All rights reserved.
Sitaram P Velaga, Srinivas Basavoju, Dan Boström   +2 more
exaly   +2 more sources

Syntheses and pharmacokinetics properties of an iloperidone pharmaceutical cocrystal

Inorganic Chemistry Communication, 2014
We report here a pharmaceutical cocrystal, which was composed of iloperidone with 3, 5-pyridinedicarboxlic acid by crystal engineering strategy. It was characterized by single crystal X-ray and powder X-ray diffraction, which demonstrated that the ...
Jiangtao Jia, Qin Li, Guangshan Zhu
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Stability screening of pharmaceutical cocrystals

Pharmaceutical Development and Technology, 2021
An efficient protocol for assessing both the chemical and physical stability of cocrystalline forms of active pharmaceutical ingredients (APIs) is proposed. In this protocol, the cocrystalline material is used to prepare two standard formulations, mimicking wet granulations, to make low-dose tablets.
Kenneth C, Waterman, Alisa K, Waterman, Teslin M, Botoy, Jane, Li, Fenghe, Qiu, Michael, Hawley   +5 more
openaire   +2 more sources