Results 81 to 90 of about 666,519 (246)

Design, Synthesis, and Evaluation of Naphthyl Pyrazino‐Pyrido‐Pyrimidinones Targeting the Phosphoinositide 3‐Kinase/Alpha‐Serine/Protein Kinase B/Mammalian Target of Rapamycin Pathway

ChemistryOpen, Volume 15, Issue 2, February 2026.
Rationally designed naphthyl pyrazino‐pyrido‐pyrimidinones 3 and 4 inhibited 85%–94% of cancer cell growth. Compound 4 exhibited IC50 = 7.8–12.8 µM with tumor selectivity. Both induced G1 arrest and modulated ULK1, STAT3, alpha‐serine/protein kinase B (AKT), and autophagy via phosphoinositide 3‐kinase/mammalian target of rapamycin (PI3K/mTOR ...
Marcelo F. Marchiori, Gabriel da Silva, Daniel F. Kawano, Andréia M. Leopoldino, Enrique Madruga, Ana Martinez, Ivone Carvalho   +6 more
wiley   +1 more source

Spectral characterization and vibrational mode study of cocrystal of acetaminophen and aspirin based on terahertz/Raman spectroscopy combined with DFT theory calculation

Results in Chemistry
In recent years, pharmaceutical cocrystal has become a hot field in drug development, which improves the solubility, stability, and bioavailability of drugs.
Haofei Sun, Bo Peng, Xinyi Bai, Bo Su, Cunlin Zhang, Hailin Cui, Shengbo Zhang, Kai Li   +7 more
doaj   +1 more source

De Novo Design and Synthesis of Novel Benzoxazinone Derivatives Targeting Dihydroxyacid Dehydratase

Plant Biotechnology Journal, Volume 24, Issue 2, Page 567-581, February 2026.
ABSTRACT Dihydroxyacid dehydratase (DHAD), a key enzyme in the branched‐chain amino acid (BCAA) synthesis pathway, is a promising herbicide target. Currently, no commercial herbicides target DHAD, and no inhibitors are in development. Structural analysis suggests that coordination with iron–sulfur clusters and hydrophobic interactions with Tyr215 and ...
Bo He, Yanhao Hu, Xu He, Wang Chen, Wei Yan, Xin Zang, Jiahai Zhou, Yonghao Ye   +7 more
wiley   +1 more source

Dynamic Control of Two‐Component Aggregation and Color‐Tunable Emission via Charge‐Transfer Coassembly

Aggregate, Volume 7, Issue 1, January 2026.
Charge‐transfer coassembly enables precise control over the dynamic aggregation process, resulting in morphology evolution from amorphous aggregates to rod‐like and needle‐like microcrystals, accompanied by a significant fluorescence enhancement. This strategy yields widely tunable solid‐state emission from green to orange‐red, unveiling fundamental ...
Huiting Mao, Xinqi Ge, Jiahui Guo, Zhibo Gong, Na Ding, Shijuan Liu, Guo‐Gang Shan, Ruinian Hua   +7 more
wiley   +1 more source

A Review on Pharmaceutical Cocrystals

International Journal of Pharmaceutical Research and Applications
Pharmaceutical cocrystals are crystalline materials composed of two or more different molecules, at least one being an active pharmaceutical ingredient (API), in a fixed stoichiometric ratio, held together by non-covalent interactions.Cocrystal can be prepared by cocrystallization method.
Samina Sameer, Shinta Babu Shinta Babu, Aparna P Aparna P, Dr.Prasobh G R Dr.Prasobh G R   +3 more
openaire   +1 more source

A Proteochemometric Model for Ligands of the SLC5 Transporter Family

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
A novel proteochemometric model was developed to predict the activity and selectivity of SLC5 family inhibitors. The model's performance was validated using 10‐fold cross‐validation on publicly available datasets achieving Q2 = 0.79 and MSE < 0.32. Detailed analysis of the results enabled the identification of a new, previously unrecognized selectivity‐
Martin Juhás, Gerhard Ecker
wiley   +1 more source

Structural Characterization of Febuxostat/l-Pyroglutamic Acid Cocrystal Using Solid-State 13C-NMR and Investigational Study of Its Water Solubility

Crystals, 2017
Febuxostat (FB) is a poorly water-soluble drug that belongs to BCS class II. The drug is employed for the treatment of inflammatory disease arthritis urica (gout), and the free base, FB form-A, is most preferred for drug formulation.
Ji-Hun An, Changjin Lim, Hyung Chul Ryu, Jae Sun Kim, Hyuk Min Kim, Alice Nguvoko Kiyonga, Minho Park, Young-Ger Suh, Gyu Hwan Park, Kiwon Jung   +9 more
doaj   +1 more source

Pharmaceutical Cocrystal of Ethyl p-Methoxycinnamate: Formulation and Characterization

, 2020
Ethyl p-methoxycinamate (EPMC) is a compound derived from kencur (Kaemferia galanga) and has a pharmacological effect as an antiinflammatory. EPMC has poorly water solubility and need to be modified to increase its solubility.
Revika Rachmaniar, S. Warya, Rival Ferdiansyah, Hesti Riasari, Aswin Gumelar, Kenti   +5 more
semanticscholar   +1 more source

Dissolution rate of ciprofloxacin and its cocrystal with resorcinol

ADMET and DMPK, 2018
The synthesis of cocrystals is presented as an alternative to improve the properties of active pharmaceutical ingredients, especially those related to solubility and dissolution rate.
Clara Ràfols, Hanan Fael, Elisabet Fuguet, Breeze Outhwaite, Samuel Lee, Rebeca Ruiz   +5 more
doaj   +1 more source

Recent advances in pharmaceutical cocrystals of theophylline

Natural Products and Bioprospecting
AbstractCurrently, cocrystallization is a promising strategy for tailoring the physicochemical properties of active pharmaceutical ingredients. Theophylline, an alkaloid and the most primary metabolite of caffeine, is a readily available compound found in tea and coffee.
Yanxiao Jia, Dezhi Yang, Wenwen Wang, Kun Hu, Min Yan, Li Zhang, Li Gao, Yang Lu   +7 more
openaire   +3 more sources