Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications [PDF]
Acta Pharmaceutica Sinica B, 2021 Pharmaceutical cocrystals are multicomponent systems in which at least one component is an active pharmaceutical ingredient and the others are pharmaceutically acceptable ingredients.
Minshan Guo +3 more
doaj +3 more sources
Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs [PDF]
Pharmaceutics, 2018 Cocrystals can be used as an alternative approach based on crystal engineering to enhance specific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) when the approaches to salt or polymorph formation do not meet
Anna Karagianni +2 more
doaj +4 more sources
Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals [PDF]
Pharmaceuticals, 2023 Pharmaceutical multicomponent solids have proved to efficiently modulate the physicochemical properties of active pharmaceutical ingredients. In this context, polyphenols are interesting coformers for designing pharmaceutical cocrystals due to their wide
Francisco Javier Acebedo-Martínez +7 more
doaj +2 more sources
Mechanochemistry: A Green Approach in the Preparation of Pharmaceutical Cocrystals [PDF]
Pharmaceutics, 2021 Mechanochemistry is considered an alternative attractive greener approach to prepare diverse molecular compounds and has become an important synthetic tool in different fields (e.g., physics, chemistry, and material science) since is considered an ...
Mizraín Solares-Briones +8 more
doaj +2 more sources
Recent Advances in Pharmaceutical Cocrystals: A Focused Review of Flavonoid Cocrystals [PDF]
Molecules, 2023 Cocrystallization is currently an attractive technique for tailoring the physicochemical properties of active pharmaceutical ingredients (APIs). Flavonoids are a large class of natural products with a wide range of beneficial properties, including ...
Jia Xu +6 more
doaj +2 more sources
Pharmaceutical Cocrystals: Regulatory and Strategic Aspects, Design and Development [PDF]
Advanced Pharmaceutical Bulletin, 2016 Cocrystal is a concept of the supramolecular chemistry which is gaining the extensive interest of researchers from pharmaceutical and chemical sciences and of drug regulatory agencies.
Dipak Dilip Gadade +1 more
doaj +2 more sources
Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications [PDF]
PharmaceuticsPharmaceutical cocrystals are a well-established class of solid-state forms that can modulate the solubility, dissolution, stability, and bioavailability of active pharmaceutical ingredients without altering their molecular identity. Although traditional
Marina Monserrat Marcos Valdez +3 more
doaj +2 more sources
Pharmaceutical Cocrystals—A Review [PDF]
Proceedings, 2021 The design and synthesis of pharmaceutical cocrystals have received great interest in the recent years. Cocrystallization of drug substances offers a tremendous opportunity for the development of new drug products with superior physical and ...
Sheetal S. Buddhadev, Kevin C. Garala
doaj +2 more sources
New Lidocaine-Based Pharmaceutical Cocrystals: Preparation, Characterization, and Influence of the Racemic vs. Enantiopure Coformer on the Physico-Chemical Properties [PDF]
Pharmaceutics, 2023 This study describes the preparation, characterization, and influence of the enantiopure vs. racemic coformer on the physico-chemical properties of a pharmaceutical cocrystal.
Panpan Ma +17 more
doaj +2 more sources
Application of 1-Hydroxy-4,5-Dimethyl-Imidazole 3-Oxide as Coformer in Formation of Pharmaceutical Cocrystals [PDF]
Pharmaceutics, 2020 Two, well defined binary crystals with 1-Hydroxy-4,5-Dimethyl-Imidazole 3-Oxide (HIMO) as coformer and thiobarbituric acid (TBA) as well barbituric acid (BA) as Active Pharmaceutical Ingredients (APIs) were obtained by cocrystallization (from methanol ...
Aneta Wróblewska +8 more
doaj +2 more sources