Results 91 to 100 of about 2,773,562 (359)
Mapping Hsp104 interactions using cross‐linking mass spectrometry
FEBS Open Bio, EarlyView.This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.The C. elegans tetraspanin‐7 (tsp‐7) is a homologue of human CD63, which is a negative regulator of autophagy. The C. elegans strain, tm5761, has a dysfunctional (knockout) tsp‐7 gene. When compared to the wild‐type strain, the tm5761 strain shows increased: life‐ and health‐span; thermotolerance, and stress‐induced locomotion.
Brogan Jones +2 more
wiley +1 more source
Química Nova, 2009 A gas chromatographic method has been developed for the assay of fluvastatin sodium (FLU). FLU was silylated with N,O-bis(trimethylsilyl)trifluoroacetamide-1% trimethylchlorosilane at 90 ºC for 30 min and analysed in a DB-1 column by capillary gas ...
Serap Saglik Aslan +1 more
doaj +1 more source
Document Chunking and Learning Objective Generation for Instruction Design [PDF]
arXiv, 2018 Instructional Systems Design is the practice of creating of instructional experiences that make the acquisition of knowledge and skill more efficient, effective, and appealing. Specifically in designing courses, an hour of training material can require between 30 to 500 hours of effort in sourcing and organizing reference data for use in just the ...
arxiv
, 2012 A simple, rapid, and sensitive spectrofluorometric method was developed for the determination of three antihyperlipidemic drugs, namely, rosuvastatin calcium (RSV), ezetimibe (EZE), and pitavastatin calcium (PIT).
R. El-Bagary, E. Elkady, A. Kadry
semanticscholar +1 more source
FEBS Open Bio, EarlyView.We introduce an immunohistochemistry method to measure autophagy flux, highlighting the active degradation and recycling of cellular waste. This cost‐effective approach uses tissue samples to track key markers like LC3 and SQSTM1, revealing how cells maintain health or respond to diseases such as cancer. It bridges the gap between research and clinical
Shahla Shojaei +6 more
wiley +1 more source
FastLeakyResNet-CIR: A Novel Deep Learning Framework for Breast Cancer Detection and Classification
IEEE AccessBreast cancer is a type of disease that primarily affects the breast tissue, and it is crucial to achieve early diagnosis for successful treatment and recovery.
Ruiming Zeng +7 more
doaj +1 more source
Spectrophotometric determination of adrenaline in pharmaceutical preparations
Arabian Journal of Chemistry, 2016 AbstractA new and effective spectrophotometric method was developed for the determination of adrenaline in pharmaceutical preparations for control purposes. The condensation of Mannish reaction between 1mol of adrenaline with new ligand, 5-benzimino-1,3,4-thiodiazole-2-thione (I) in the presence of 1mol of p-formaldehyde as the condensing agent with 15–
openaire +3 more sources
FEBS Open Bio, EarlyView.Measuring AMP‐activated protein kinase (AMPK) activity in vitro is crucial for testing AMPK activators or inhibitors with therapeutic potential. Here, we report an enzyme‐linked immunosorbent assay (ELISA)‐based AMPK activity assay with simple steps and high sensitivity, which offers a simple, robust, and cost‐effective alternative to traditional ...
Trezze P. Nguyen, Shangze Lyu, Yang Liu
wiley +1 more source
Why Deprescribing Instead of Not Prescribing? [PDF]
Geriatrics, Gerontology and AgingPrescribing medications involves complex cognitive processes, and mistakes in prescription can cause serious adverse events. Deprescribing is one of the last opportunities to prevent patient harm from the use of drugs that should be avoided, especially ...
Welma Wildes Amorim +2 more
doaj +1 more source