Results 1 to 10 of about 102,422 (199)
BMC Pharmacology and Toxicology, 2022 Background Linezolid causes hematological toxicity, mostly thrombocytopenia, which leads to treatment discontinuation and failure. Recent studies revealed that during linezolid therapy, the incidence of treatment-related hematological toxicity is ...
Xiaoxi Liu +8 more
doaj +1 more source
Pharmaceuticals, 2021 Tramadol is a widely used, centrally acting, opioid analgesic compound, with additional inhibitory effects on the synaptic reuptake of serotonin and noradrenaline, as well as on the 5-HT2 and NMDA receptors.
Szabolcs Koncz +4 more
doaj +1 more source
Thrombosis Journal, 2023 The assessment of hemostasis is necessary to make suitable decisions on the management of patients with thrombotic disorders. In some clinical situations, for example, during thrombophilia screening, the presence of anticoagulants in sample makes ...
Aleksandra Frackiewicz +3 more
doaj +1 more source
FASEB BioAdvances, 2023 Chronic kidney disease (CKD) involves progressive renal fibrosis, which gradually reduces kidney function and often causes various complications in extrarenal tissues. Therefore, we investigated fibrogenesis in extrarenal tissues (heart, liver, and lungs)
Kyoka Homma +4 more
doaj +1 more source
Frontiers in Immunology, 2022 Atractylodes macrocephala Koidz. is one of the most frequently used traditional Chinese medicines for the treatment of ulcerative colitis (UC). The beneficial effect of polysaccharide from Atractylodes macrocephala Koidz.
Mengjiao Yang +13 more
doaj +1 more source
The Pharmacodynamics of Aminoglycosides [PDF]
Clinical Infectious Diseases, 1998 Recently, a more complete understanding of the pharmacodynamics of aminoglycosides has been recognized, indicating that this class of antibiotics exhibits both concentration-dependent bactericidal activity and a postantibiotic effect. This pharmacodynamic information, along with better knowledge of the mechanisms responsible for aminoglycoside toxicity,
Richard Quintiliani +3 more
openaire +2 more sources
Pharmacokinetics and Pharmacodynamics of Posaconazole [PDF]
Drugs, 2020 Posaconazole is typically used for preventing invasive yeast and mold infections such as invasive aspergillosis in high-risk immunocompromised patients. The oral suspension was the first released formulation and many pharmacokinetic and pharmacodynamic studies of this formulation have been published.
Lu Chen +5 more
openaire +6 more sources
Additive effect of 5-HT2C and CB1 receptor blockade on the regulation of sleep–wake cycle
BMC Neuroscience, 2019 Background Previous data show that serotonin 2C (5-HT2C) and cannabinoid 1 (CB1) receptors have a role in the modulation of sleep–wake cycle. Namely, antagonists on these receptors promoted wakefulness and inhibited rapid eye movement sleep (REMS) in ...
Emese Bogáthy +4 more
doaj +1 more source
Antibacterial Drug Development: A New Approach Is Needed for the Field to Survive and Thrive
Antibiotics, 2020 It is often said that the marketplace for new antibiotics is broken. This notion is supported by the observation that many recently-approved antibiotics to treat drug-resistant bacteria have failed commercially in a spectacular fashion.
M. Courtney Safir +4 more
doaj +1 more source
BMC Infectious Diseases, 2021 Background This systematic review and meta-analysis explored the relationship between vancomycin (VCM) monitoring strategies and VCM effectiveness and safety.
Moeko Tsutsuura +14 more
doaj +1 more source