Results 101 to 110 of about 187,044 (318)

Pharmacokinetics and Pharmacodynamics in Space [PDF]

The Pharmacokinetics and Pharmacodynamics Panel met on 29-30 Aug. 1988 at the Lunar and Planetary Institute in Houston, Texas to discuss pharmacokinetic and pharmacodynamic implications of space flight and make recommendations for operational and ...
Cintron, Nitza M., Putcha, Lakshmi
core   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Remdesivir for the treatment of coronavirus COVID-19: A meta-analysis of randomised controlled trials

Journal of Global Antimicrobial Resistance, 2021
Yuki Enoki, Yuki Igarashi, Yuki Watabe, Kyoka Honma, Yuto Suzuki, Yukitaka Hayashi, Kana Hiraoka, Kazuaki Taguchi, Kazuaki Matsumoto   +8 more
doaj   +1 more source

Single-dose pharmacokinetics and pharmacodynamics of oral tenofovir and emtricitabine in blood, saliva and rectal tissue: a sub-study of the ANRS IPERGAY trial [PDF]

, 2016
Julien Fonsart, Sentob Saragosti, Milad Taouk, Gilles Peytavin, Lane R. Bushman, Isabelle Charreau, Allan J. Hance, Lauriane Goldwirt, Stéphane Morel, Fabrizio Mammano, Bénédicte Loze, Catherine Capitant, François Clavel, Nadia Mahjoub, Laurence Meyer, Peter L. Anderson, Constance Delaugerre, Jean‐Michel Molina   +17 more
openalex   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine

Translational Psychiatry
Most current approaches to establish subgroups of depressed patients for precision medicine aim to rely on biomarkers that require highly specialized assessment. Our present aim was to stratify participants of the UK Biobank cohort based on three readily
Nora Eszlari, Gabor Hullam, Zsofia Gal, Dora Torok, Tamas Nagy, Andras Millinghoffer, Daniel Baksa, Xenia Gonda, Peter Antal, Gyorgy Bagdy, Gabriella Juhasz   +10 more
doaj   +1 more source

Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain

Frontiers in Pharmacology, 2019
Sigma-1 receptors (S1R) and sigma-2 receptors (S2R) may modulate nociception without the liabilities of opioids, offering a promising therapeutic target to treat pain.
Thomas J. Cirino, Shainnel O. Eans, Jessica M. Medina, Lisa L. Wilson, Marco Mottinelli, Sebastiano Intagliata, Christopher R. McCurdy, Jay P. McLaughlin   +7 more
doaj   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy

Fluids and Barriers of the CNS
Background Chemotherapy-induced peripheral neuropathy (CIPN) represents a major unmet medical need that currently has no preventive and/or curative treatment.
Yang Hu, Milda Girdenyté, Lieke Roest, Iida Liukkonen, Maria Siskou, Frida Bällgren, Margareta Hammarlund-Udenaes, Irena Loryan   +7 more
doaj   +1 more source

β-Lactam Pharmacokinetic/Pharmacodynamic Target Attainment in Intensive Care Unit Patients: A Prospective, Observational, Cohort Study [PDF]

, 2023
Romain Guilhaumou, Constance Chevrier, Jean Loup Setti, Élisabeth Jouve, Amélie Marsot, Nathan Julian, Olivier Blin, Pierre Simeone, David Lagier, Djamel Mokart, Nicolas Bruder, Marc Garnier, Lionel Velly   +12 more
openalex   +1 more source