Results 101 to 110 of about 181,985 (340)

PHARMACOKINETICS AND PHARMACODYNAMICS OF CURCUMIN [PDF]

, 2007
Curcuma spp. contain turmerin, essential oils, and curcuminoids, including curcumin. Curcumin [1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is regarded as the most biologically active constituent of the spice turmeric and it comprises 2-8% of most turmeric preparations.
Sharma, Ricky A., Steward, William P., Gescher, Andreas J.   +2 more
openaire   +5 more sources

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

Advanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo, Qiancheng Mao, Xinyu Fang, Liuxuan Huang, Haoquan Tian, Wenguang Yang, Feiyue Zhou, Ke Ma   +7 more
wiley   +1 more source

Adherence to a Six-Dose Regimen of Artemether-Lumefantrine for Treatment of Uncomplicated Plasmodium Falciparum Malaria in Uganda. [PDF]

, 2004
Measuring baseline levels of adherence and identifying risk factors for non-adherence are important steps before the introduction of new antimalarials. In Mbarara in southwestern Uganda, we assessed adherence to artemether-lumefantrine (Coartem) in its ...
Bajunirwe, F, Biraro, S, Checchi, F, Fogg, C, Guthmann, J P, Kiguli, J, Kyomugisha, A, Musabe, J, Namiiro, P, Piola, P   +9 more
core   +2 more sources

Vitiligo Signature‐Based Drug Screening Identifies Fulvestrant as a Novel Immunotherapy Combination Strategy

Advanced Science, EarlyView.
A vitiligo‐derived gene signature predicts response to immune checkpoint blockade across multiple cancer cohorts, providing a framework for patient stratification. Building on this, Fulvestrant—a clinically approved estrogen receptor degrader—further enhances antitumor immunity by reprogramming tumor‐associated macrophages and promoting CD8⁺ T cell ...
Jie Zhu, Liting Huang, Suzhen Bi, WeiKaixin Kong, Wanting Feng, Yingjia Li, Zhengwei Xie, Peipei Shan, Sujie Zhu   +8 more
wiley   +1 more source

Pyridoxic Acid as Endogenous Biomarker of Renal Organic Anion Transporter Activity: Population Variability and Mechanistic Modeling to Predict Drug–Drug Interactions

CPT: Pharmacometrics & Systems Pharmacology
Pyridoxic acid (PDA) was suggested as a potential endogenous biomarker to assess in vivo renal organic anion transporter (OAT) 1 and 3 activity. Here, we first investigated the population variability in the plasma baseline levels of PDA using data from ...
Aarzoo Thakur, Sumathy Mathialagan, Emi Kimoto, Manthena V. S. Varma   +3 more
doaj   +1 more source

Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation

Advanced Science, EarlyView.
Native thioredoxin‐1 (TRX) stimulates proliferation and rescues stem cells and cancer cells from multiple stressors by suppressing p53 and inhibiting ferroptosis via GPX4/SLC7A11 upregulation mediated by enhanced KLF4 expression and p53 promoter binding.
Jian Wu, Xiaobei Wang, Parker Mathews, Shaima Jabbar, Min Zhang, Haim Moskowitz, Wei Duan, David P. Nichols, George William Schaaf, John D. Olson, Andrew N. Macintyre, J. Daniel Bourland, Ivan Spasojevic, Jen‐Tsan Ashley Chi, Joel Ross, Nelson Chao, J. Mark Cline, Peter B. Heifetz, Yubin Kang   +18 more
wiley   +1 more source

Different molecular targets, one purpose – treatment of depression

Current Issues in Pharmacy and Medical Sciences, 2020
Although vast scientific progress has been made, the current pharmacotherapy of depression is still not fully effective. In adults, depressive disorders are among the most common diseases in industrialized countries, impact upon all aspects of family and
Burat Magdalena, Gibula-Tarlowska Ewa, Kedzierska Ewa   +2 more
doaj   +1 more source

Pharmacodynamics of doxycycline [PDF]

Clinical Microbiology and Infection, 2000
P. Domenico, Cheston B. Cunha, Burke A. Cunha   +2 more
openaire   +3 more sources

"Pharmacology of salicin derivatives in sheep" : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand [PDF]

, 2016
Content removed from thesis due to copyright reasons: Figure 1.20(e). S. viminalis. Retrieved from Valerie J.:http://gardeners-word.blogspot.co.uk/Sheep suffer from pain during various husbandry practices as well as during injury or diseases such as ...
Mathurkar, Shashwati Chandrakant
core  

Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation

Advanced Science, EarlyView.
Pathological retinal/choroidal neovascularization drives vision loss in DR and AMD. Current anti‐VEGF injections, while effective, require invasive, frequent administration. Pene/LQ015, is developed a novel topical anti‐VEGFA nanobody formulation achieving therapeutic intraocular levels through penetratin analog‐enhanced delivery.
Chong Chen, Min Zhu, Xingyan Fan, Kangjia Lv, Kuan Jiang, Yuchen Zhang, Haoliang Zhang, Xinming Qi, Benjamin TK Lee, Yakun Wan, Gang Wei, Kun Liu, Xun Xu   +12 more
wiley   +1 more source