Results 51 to 60 of about 181,985 (340)
LncRNA Gm35585 transcriptionally activates the peroxidase EHHADH against diet-induced fatty liver
Experimental and Molecular MedicineMetabolic-dysfunction-associated steatotic liver disease is one of the most common chronic liver diseases worldwide and has no approved treatment thus far.
Ming Jin +9 more
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European PsychiatryIntroduction Depression is a highly prevalent, multifactorial, complex disorder, its etiology is assumed to involve both genetic and environmental factors.
M. Csikos +6 more
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The monoamine theory of depression as a target to effective pharmacotherapy
Current Issues in Pharmacy and Medical Sciences, 2023 Depression is one of the greatest current mental disorders. Depressive disorder may affect everyone and it causes difficulties in social functioning and may lead to death via suicide.
Karabin Tomasz +2 more
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Advanced Healthcare Materials, EarlyView.Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao +20 more
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Frontiers in Pharmacology, 2021 Protein therapeutics have witnessed tremendous use and application in recent years in treatment of various diseases. Predicting efficacy and safety during drug discovery and translational development is a key factor for successful clinical development of
Vittal Shivva +5 more
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PHARMACOKINETICS AND PHARMACODYNAMICS
British Journal of Anaesthesia, 1979 Many physiological systems appear to present data that is random or without order. The origins of this disorder are often attributed to variability introduced by the multifactorial determinants of the system. This classical view of physiological randomness has also been widely discussed in quantitative pharmacological systems. However, since the early
openaire +3 more sources
PARP inhibition: a promising therapeutic target in ovarian cancer [PDF]
, 2015 Ovarian cancer is burdened by the highest mortality rate among gynecological cancers. Gold standard is represented by the association of platinum-taxane -based chemotherapy and radical surgery.
Abdul Halim, T +14 more
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Self‐Assembling Multi‐Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma
Advanced Healthcare Materials, EarlyView.A novel modular T‐cell engager platform, MATCH, is developed for personalized multiple myeloma therapy. MATCH uses complementary oligonucleotide‐linked Fab’ fragments to enable flexible targeting of MM antigens and controlled T‐cell activation. The system shows potent, antigen‐specific cytotoxicity in vitro and in vivo, highlighting its potential for ...
Shannuo Li +8 more
wiley +1 more source
Translational PsychiatryThe frequent co-occurrence of chronic pain (CP) and depression is a well-known phenomenon, supported by both the high prevalence of major depression among CP patients and studies describing a substantial genetic correlation between the two phenotypes ...
Sandor Krause +4 more
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Monitoring of Cardiorespiratory Parameters in Rats—Validation Based on Pharmacological Stimulation
Pharmaceuticals, 2021 The methods used in preclinical studies should minimize the suffering and the number of animals but still provide precise and consistent results enabling the introduction of drug candidates into the phase of clinical trials.
Joanna Miklosz +4 more
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