Results 91 to 100 of about 36,199 (325)

Near real-time vaccine safety surveillance using electronic health records-a systematic review of the application of statistical methods. [PDF]

, 2016
PURPOSE: Pre-licensure studies have limited ability to detect rare adverse events (AEs) to vaccines, requiring timely post-licensure studies. With the increasing availability of electronic health records (EHR) near real-time vaccine safety surveillance ...
Abt, Belongia, Bonhoeffer, Brown, Bryan, Bryan, Burwen, Carey, Chen, Cook, Cook, Crawford, Dal Pan, Daley, Davis, Donegan, Ellenberg, Enger, Franks, Gee, Greene, Greene, Grigg, Gsponer, Huang, Jennison, Kawai, Klein, Kuldorff, Kulldorff, Kulldorff, Lanes, Lee, Li, Lieu, Lopalco, Loughlin, Maro, McNicholas, McPhillips, Murdoch, Musonda, Nelson, Nelson, Nelson, O'Hagan, Salmon, Silva, Stratton, Tse, Tseng, Waldman, Weintraub, Yih, Yih   +54 more
core   +1 more source

Supplementing Single‐Arm Trials with External Control Arms—Evaluation of German Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
As single‐arm trials (SATs) are increasingly used in pharmaceutical research, the validity of such study designs needs to be critically assessed. We characterize the feasibility of supplementing SATs with real‐world data (RWD)‐derived external control arms by determining the proportion of SATs on breast cancer and amyotrophic lateral sclerosis (ALS ...
Martin Russek, Jonas Peltner, Britta Haenisch   +2 more
wiley   +1 more source

Current status, and future prospects of pharmaco-epidemiology and post-marketing surveillance in Saudi Arabia: A review of literature

Saudi Pharmaceutical Journal, 2018
Background: Pharmacoepidemiology is the concept used for evaluating the impact of drugs among a large number of people in the post-marketing phase. The use of this concept makes it increasingly necessary to detect the recurrence of drug-related anomalies
Ashraf El-Metwally
doaj  

Antidepressants and the Risk of Fall-Related Injury in Older Adults with Incident Depression in the United States: A Comparative Safety Analysis

Pharmacoepidemiology, 2023
Though it is well documented that antidepressants are associated with an increased risk of falls in older adults at the drug class level, the comparative risk between individual antidepressants for fall injury in older adults with depression is unknown ...
Ashley Tabah, Laura S. Gold, Zachary A. Marcum, Ryan N. Hansen   +3 more
doaj   +1 more source

Model‐Informed Precision Dosing of Busulfan for Children and Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Critical Evaluation of Current PK Models and Dose Recommendations

Clinical Pharmacology &Therapeutics, EarlyView.
Busulfan is administered intravenously in conditioning regimens prior to allogeneic hematopoietic stem cell transplantation (HSCT), with model‐informed precision dosing (MIPD) targeting a 4‐day cumulative AUC of 80–100 mg*hour/L. Three pharmacokinetic (PK) models—Bognar, Langenhorst, and McCune—were evaluated using data with a minimum of 1 and a median
Rashudy F. Mahomedradja, Tim Bognàr, Kaj E. van Schie, Ilse T. Kuipers, Moniek A. de Witte, Jurgen H.E. Kuball, Erfan Nur, Bram J. Wilhelm, Marise R. Heerma van Voss, Linda Franken, Arief Lalmohamed, Eleonora (Noortje) L. Swart, Dave C. de Leeuw, Imke H. Bartelink   +13 more
wiley   +1 more source

Pharmacoepidemiology

مجله دانشکده پزشکی اصفهان, 2016
Pharmacoepidemiology
Ali Mohammad Sabzghabaee
doaj  

Clinical Indicators of Cardiovascular Risk in Adult Patients Undergoing Chemotherapy: A Protocol for Scoping Review

Pharmacoepidemiology, 2023
Heart disease and cancer are the main causes of morbidity and mortality worldwide. As the number of cancer survivors increases, cardiotoxicity associated with cancer treatment has become a major concern as it presents a substantial challenge in the ...
Karolini Zuqui Nunes, Jonathan Grassi, Andressa Bolsoni Lopes, Lucas Dalvi Armond Rezende, Julia Anhoque Cavalcanti, Karoline Neumann Gomes, Julia Antonietta Dantas da Silva, Luís Carlos Lopes-Júnior   +7 more
doaj   +1 more source

Antibiotic use during pregnancy and neurodevelopmental outcomes of offspring in early childhood [PDF]

, 2020
There is limited research on the effects of antibiotic use during pregnancy on neurodevelopmental outcomes of offspring in early childhood. The aim of this study was to investigate associations between antibiotic use during early pregnancy and ...
Gamache, Tressa
core  

Imported malaria in the UK, 2005 to 2016: estimates from primary care electronic health records [PDF]

, 2018
Objective To investigate trends in the incidence of imported malaria in the UK between 2005 and 2016. Design Analysis of longitudinal electronic health records (EHRs) in The Health Improvement Network (THIN) primary care database.
Bastaki, Hamad, Cassell, Jackie, Marston, Louise, Rait, Greta   +3 more
core   +3 more sources

Pharmacogenetic Implementation Studies—Lessons Learned From the PREPARE Study

Clinical Pharmacology &Therapeutics, EarlyView.
The Ubiquitous Pharmacogenomics consortium (www.upgx.eu) has recently completed and published the Preemptive Pharmacogenomic Testing for Preventing Adverse Drug Reactions (PREPARE) study on the implementation of panel‐based pharmacogenetic testing. PREPARE has provided interesting lessons for the design, execution, and interpretation of future clinical
Henk‐Jan Guchelaar, Cathelijne H. van der Wouden, Lisanne E. N. Manson, Heshu Abdullah‐Koolmees, Kathrin Blagec, Tanja Blagus, Stefan Böhringer, Erika Cecchin, Ka‐Chun Cheung, Vera H. M. Deneer, Siv Jonsson, Candace Joefield‐Roka, Katja S. Just, Mats O. Karlsson, Lidija Konta, Rudolf Koopmann, Marjolein Kriek, Thorsten Lehr, Christina Mitropoulou, Victoria Rollinson, Rossana Roncato, Matthias Samwald, Elke Schaeffeler, Maria Skokou, Matthias Schwab, Daniela Steinberger, Julia C. Stingl, Roman Tremmel, Richard M. Turner, Mandy H. van Rhenen, Cristina L. Dávila‐Fajardo, Vita Dolžan, George P. Patrinos, Munir Pirmohamed, Gere Sunder‐Plassmann, Giuseppe Toffoli, Jesse J. Swen, Ubiquitous Pharmacogenomics Consortium   +37 more
wiley   +1 more source