Results 101 to 110 of about 34,898 (217)

Data quality in European primary care research databases. Report of a workshop held in London September 2013 [PDF]

, 2014
Primary care research databases provide a significant resource for health services and epidemiological research. However since data are recorded primarily for clinical care their suitability for research may vary widely according to the research ...
Beloff, Natalia, Boggon, Rachael, Kalra, Dipak, Puri, Shivani, Tate, A Rosemary, Williams, Tim   +5 more
core   +1 more source

Treatment effectiveness of galcanezumab versus traditional oral migraine preventive medications at 3 months: Results from the TRIUMPH study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study assesses the 3‐month effectiveness of the calcitonin gene‐related peptide monoclonal antibody galcanezumab versus traditional oral migraine preventive medications. Background Studies comparing the effectiveness of calcitonin gene‐related peptide monoclonal antibodies versus traditional oral migraine preventive medications ...
Richard B. Lipton, Miguel J. A. Láinez, Zubair Ahmed, Carlos Vallarino, Diego Novick, Maurice Vincent, Lars Viktrup, Rebecca L. Robinson   +7 more
wiley   +1 more source

Predictors of a Gabapentinoid–Loop‐Diuretic Prescribing Cascade in U.S. Nursing Home Residents

Journal of the American Geriatrics Society, EarlyView.
Among 23,544 older adult long‐stay nursing home residents who initiated a gabapentinoid in the nursing home (2016–2022), 4.2% experienced a loop diuretic prescribing cascade within 90 days. Predictors of the prescribing cascade included older age, higher medication burden (≥ 15 medications), current receipt of non‐loop diuretics, and titration of ...
Kaleen N. Hayes, Emmanuelle Belanger, Arman Oganisian, Richa Joshi, Xiao (Joyce) Wang, Lexie R. Grove, Kelsey L. Corcoran, Andrew R. Zullo   +7 more
wiley   +1 more source

Perspectives of Older Patients on the Complexity of Medication Use

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Medication use complexity is associated with non‐adherence, hospitalizations, and lower quality of life. It is most frequently measured with the Medication Regimen Complexity Index (MRCI). This instrument estimates the complexity of a patient's medication regimen, taking into account the pharmaceutical dosage forms and routes ...
Charlotte M. Falke, Mariëlle F. J. Koolen, Samuel L. Timmer, Fatma Karapinar‐Çarkit, Marcel L. Bouvy, Antoine C. G. Egberts, Wilma Knol   +6 more
wiley   +1 more source

SUPREME-HN: a retrospective biomarker study assessing the prognostic value of PD-L1 expression in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck. [PDF]

, 2019
BACKGROUND:Programmed cell death ligand-1 (PD-L1) expression on tumor cells (TCs) is associated with improved survival in patients with head and neck squamous cell carcinoma (HNSCC) treated with immunotherapy, although its role as a prognostic factor is ...
Baste, Neus, Clayburgh, Daniel, Cohen, Ezra EW, Fountzilas, George, Fujii, Takashi, Khaliq, Asud, Kim, Edward S, Lin, Derrick, Lipworth, Loren, Mehlhorn, Holger, Melillo, Giovanni, Pai, Sara I, Resteghini, Carlo, Shara, Nawar, Shire, Norah, Stokes, Michael, Twumasi-Ankrah, Philip, Wang, Huifen, Wildsmith, Sophie, Zhang, Jun   +19 more
core   +1 more source

Locum doctor working: A qualitative exploration of the implications for learning and professional development

Medical Education, EarlyView.
Abstract Background In the English National Health Service, and other health care systems internationally, there have been growing numbers of doctors working on a short‐ or long‐term temporary basis as ‘locums’. Social environments and professional relationships are fundamental to learning in clinical contexts; however, locums are often positioned at ...
Jane Ferguson, Gemma Stringer, Kieran Walshe, Thomas Allen, Christos Grigoroglou, Evangelos Kontopantelis, Darren M. Ashcroft   +6 more
wiley   +1 more source

Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Eeva Pylkkö, Émeline Courtois, Anne Paakinaho, Sirpa Hartikainen, Valtteri Kaasinen, Alexis Elbaz, Anne C. M. Thiébaut, Ismaïl Ahmed, Anna‐Maija Tolppanen   +8 more
wiley   +1 more source

“My Addiction Doesn’t Define Me”—Experiences of Stigma among Mothers with Opioid Use Disorder

Pharmacoepidemiology
Opioid use in women has increased by 300% since 1999, and opioid use disorder among pregnant women has quadrupled. The stigma of substance use disorder is a significant barrier to treatment, especially among women.
Christine Bakos-Block, Andrea Yatsco, A. Sarah Cohen, Francine Vega, Tiffany Champagne-Langabeer   +4 more
doaj   +1 more source

Non‐steroidal anti‐inflammatory drugs versus acetaminophen and risk of venous thromboembolism: An active comparator new user cohort study

Journal of Internal Medicine, Volume 299, Issue 3, Page 381-397, March 2026.
Abstract Background Previous observational studies have reported an increased risk of venous thromboembolism (VTE) among non‐steroidal anti‐inflammatory drug (NSAID) users compared with non‐users. However, these studies may have been subject to bias due to unmeasured confounders related to patient conditions requiring NSAIDs.
Yuichiro Matsuo, Akira Okada, Hideo Yasunaga   +2 more
wiley   +1 more source

Remdesivir and the Liver: A Concise Narrative Review of Remdesivir-Associated Hepatotoxicity in Patients Hospitalized Due to COVID-19

Pharmacoepidemiology
Severe acute respiratory syndrome coronavirus 2 has infected millions of people, but about 20% of infected individuals do not develop symptoms. COVID-19 is an inflammatory disease that affects a portion of individuals infected with the virus and it is ...
Alireza FakhriRavari, Mazyar Malakouti
doaj   +1 more source