Results 1 to 10 of about 52,343 (282)

Pharmacogenetics and Forensic Toxicology: A New Step towards a Multidisciplinary Approach

Toxics, 2021
Pharmacogenetics analyzes the individual behavior of DNA genes after the administration of a drug. Pharmacogenetic research has been implemented in recent years thanks to the improvement in genome sequencing techniques and molecular genetics. In addition
Nunzio Di Nunno, Massimiliano Esposito, Antonina Argo, Monica Salerno, Francesco Sessa   +4 more
doaj   +2 more sources

Knowledge, perceptions and confidence of physicians and pharmacists towards pharmacogenetics practice in Kuwait. [PDF]

PLoS ONE, 2018
BACKGROUND:Pharmacogenetics practice has been successfully implemented in many developed countries to enhance personalized medicine and improve clinical and economic outcomes.
Abdullah Albassam, Shahad Alshammari, Ghadeer Ouda, Samuel Koshy, Abdelmoneim Awad   +4 more
doaj   +2 more sources

One Step Ahead in Realizing Pharmacogenetics in Low- and Middle-Income Countries: What Should We Do? [PDF]

Journal of Multidisciplinary Healthcare
Yudisia Ausi,1,2 Melisa Intan Barliana,2,3 Maarten J Postma,3,4 Auliya A Suwantika3,5 1Doctor Program in Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia; 2Department of Biological Pharmacy, Faculty of Pharmacy, Universitas ...
Ausi Y, Barliana MI, Postma MJ, Suwantika AA   +3 more
doaj   +2 more sources

Inconsistency in race and ethnic classification in pharmacogenetics studies and its potential clinical implications

Pharmacogenomics and Personalized Medicine, 2019
Frederick Zhang,1 Joseph Finkelstein21Center for Bioinformatics and Data Analytics, Columbia University Irving Medical Center, New York, NY, USA; 2Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY ...
Zhang F, Finkelstein J
doaj   +2 more sources

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update

Clinical pharmacology and therapy, 2022
CYP2C19 catalyzes the bioactivation of the antiplatelet prodrug clopidogrel, and CYP2C19 genotype impacts clopidogrel active metabolite formation. CYP2C19 intermediate and poor metabolizers who receive clopidogrel experience reduced platelet inhibition ...
Craig R. Lee, Jasmine A. Luzum, K. Sangkuhl, Roseann S. Gammal, M. Sabatine, C. Stein, D. Kisor, N. Limdi, Yee Ming Lee, S. Scott, J. Hulot, D. Roden, A. Gaedigk, K. Caudle, T. Klein, Julie A. Johnson, A. Shuldiner   +16 more
semanticscholar   +1 more source

The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin‐Associated Musculoskeletal Symptoms

Clinical pharmacology and therapy, 2022
Statins reduce cholesterol, prevent cardiovascular disease, and are among the most commonly prescribed medications in the world. Statin‐associated musculoskeletal symptoms (SAMS) impact statin adherence and ultimately can impede the long‐term ...
R. Cooper-DeHoff, M. Niemi, L. Ramsey, Jasmine A. Luzum, E. Tarkiainen, R. Straka, L. Gong, S. Tuteja, R. Wilke, M. Wadelius, Eric A. Larson, D. Roden, T. Klein, S. Yee, R. Krauss, R. Turner, L. Palaniappan, A. Gaedigk, K. Giacomini, K. Caudle, D. Voora   +20 more
semanticscholar   +1 more source

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy

Clinical pharmacology and therapy, 2021
Opioids are mainly used to treat both acute and chronic pain. Several opioids are metabolized to some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone, and methadone).
K. Crews, A. Monte, Rachel Huddart, K. Caudle, E. Kharasch, A. Gaedigk, H. M. Dunnenberger, J. Leeder, J. Callaghan, C. Samer, T. Klein, Cyrine E. Haidar, S. V. Van Driest, G. Ruaño, K. Sangkuhl, L. Cavallari, D. Müller, C. Prows, M. Nagy, A. Somogyi, T. Skaar   +20 more
semanticscholar   +1 more source

Cost Effectiveness of Pharmacogenetic Testing for Drugs with Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines: A Systematic Review

Clinical pharmacology and therapy, 2022
The objective of this study was to evaluate the evidence on cost‐effectiveness of pharmacogenetic (PGx)–guided treatment for drugs with Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines.
Sarah A. Morris, A. Alsaidi, Allison Verbyla, Adilen Cruz, Casey Macfarlane, Joseph Bauer, J. Patel   +6 more
semanticscholar   +1 more source

Pharmacogenetics Guidelines: Overview and Comparison of the DPWG, CPIC, CPNDS, and RNPGx Guidelines

Frontiers in Pharmacology, 2021
Many studies have shown that the efficacy and risk of side effects of drug treatment is influenced by genetic variants. Evidence based guidelines are essential for implementing pharmacogenetic knowledge in daily clinical practice to optimize ...
H. Abdullah-Koolmees, Antonius M. van Keulen, M. Nijenhuis, V. Deneer   +3 more
semanticscholar   +1 more source

Pharmacogenetics of Direct Oral Anticoagulants: A Systematic Review

Journal of Personalized Medicine, 2021
Dabigatran, rivaroxaban, apixaban, edoxaban, and betrixaban are direct oral anticoagulants (DOACs). Their inter-individual variability in pharmacodynamics and pharmacokinetics (transport and metabolism) is high, and could result from genetic ...
Johanna Raymond, L. Imbert, Thibault Cousin, T. Duflot, R. Varin, J. Wils, F. Lamoureux   +6 more
semanticscholar   +1 more source