Results 111 to 120 of about 52,343 (282)
Pharmacogenetics to guide cardiovascular drug therapy
Nature Reviews Cardiology, 2021 Julio D. Duarte, L. Cavallari
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Pharmacogenetics: An Important Part of Drug Development with A Focus on Its Application
International Journal of Biomedical Investigation, 2018 Since the human genome project in 2003, the view of personalized medicine to improve diagnosis and cure diseases at the molecular level became more real.
JT Oates, D. Lopez
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Developmental Medicine &Child Neurology, EarlyView.Abstract Aim To evaluate personalized care or precision medicine initiatives, including mobile health (mHealth) technology and genetic screening, in a South African paediatric epilepsy clinic. Method This exploratory prospective observational pilot study included 39 children aged 4 years or older with drug‐resistant epilepsy (ongoing seizures despite ...
Ian S. Olivier +12 more
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Pharmacogenetics of tamoxifen in breast cancer patients of African descent: Lack of data
Clinical and Translational ScienceTamoxifen, a selective estrogen receptor modulator, is used to treat hormone receptor‐positive breast cancer. Tamoxifen acts as a prodrug, with its primary therapeutic effect mediated by its principal metabolite, endoxifen. However, tamoxifen has complex
Bianca Kruger +3 more
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White paper on best practices for translational research in neuroendocrine neoplasms
Journal of Neuroendocrinology, EarlyView.Abstract Basic and translational investigations play a crucial role in advancing our understanding of neuroendocrine neoplasms (NENs). In this white paper by the Basic and Translational Research Group of the European Neuroendocrine Tumor Society, we discuss the qualities and drawbacks of current disease models and propose good practices for integrating
Jerome Cros +10 more
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Pediatric Anesthesia, EarlyView.ABSTRACT Background Propofol is a commonly used intravenous sedative and general anesthetic, with rapid onset and short duration of action. It has a narrow therapeutic index and significant interindividual variability in dosing requirements, which may elevate risks of its use, particularly in children.
Lindy Moxham +4 more
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Insights from Bibliometric Analysis of Epilepsy Research in Morocco between 1969 and 2024
Psychiatry InternationalEpilepsy is a critical neurological condition characterized by the disturbance of the excitatory neuron network, resulting in recurrent seizures. It is a serious health problem requiring intensive attention.
Abdelaziz Zennati +2 more
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Developmental Neurobiology, Volume 85, Issue 4, October 2025.Abstract Autism spectrum disorder (ASD) and bipolar disorder (BD) are psychiatric diseases that may overlap in common neurodevelopmental and genetic basis. Forkhead Box P1 (FOXP1), Synaptic Ras GTPase‐activating protein 1 (SYNGAP1), and Dedicator of Cytokinesis 4 (DOCK4) genes are critical for synaptic plasticity, neuronal communication, and brain ...
Elvan Çiftçi +8 more
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British Journal of Clinical Pharmacology, Volume 91, Issue 9, Page 2534-2542, September 2025.Aims Pharmacogenomics enables personalization of drug therapy improving effectiveness and/or safety. Dihydropyrimidine dehydrogenase [DPYD] testing prior to fluoropyrimidine chemotherapy was commissioned by NHS England in response to an update from the Medicines and Healthcare products Regulatory Agency.
Nisha Shaunak +5 more
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