Results 111 to 120 of about 69,154 (279)

Transgenic overexpression of steroid sulfatase alleviates cholestasis

Liver Research, 2017
Background and Aim: Sulfotransferase (SULT)-mediated sulfation and steroid sulfatase (STS)-mediated desulfation represent two critical mechanisms that regulate the chemical and functional homeostasis of endogenous and exogenous molecules.
Mengxi Jiang, Meishu Xu, Songrong Ren, Kyle W. Selcer, Wen Xie   +4 more
doaj   +1 more source

Precision medicine in cutaneous melanoma—A comprehensive review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Precision medicine tailors treatment to each patient, beginning with detailed diagnostics. In melanoma, it has advanced considerably: Some methods are in practice and guidelines, while others are commercially available but not routine. This review highlights current and emerging approaches, including molecular profiling, imaging, biomarkers and AI ...
Markus Reitmajer, Lukas Flatz
wiley   +1 more source

Rational development of gemcitabine-based nanoplatform for targeting SERPINB9/Granzyme B axis to overcome chemo-immune-resistance

Nature Communications
SERPINB9, an endogenous inhibitor of granzyme B (GzmB), has emerged as a critical factor in the resistance to immunotherapy by protecting cancer cells from GzmB-induced cytotoxicity. However, its role in chemosensitivity remains unknown.
Haozhe Huang, Yiqing Mu, Yixian Huang, Beihong Ji, Yifei Wang, Chien-Yu Chen, Yuang Chen, Zhangyi Luo, Sihan Li, Ziqian Zhang, Luxuan Wang, James F. Conway, Da Yang, Junmei Wang, Jingjing Sun, Song Li   +15 more
doaj   +1 more source

Comparison of Human and Canine P‐Glycoprotein Substrates at R, P, and H Binding Sites

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT P‐glycoprotein (P‐gp) greatly impacts substrate drug disposition, so much so that regulatory agencies recommend ascertaining the P‐gp status of active pharmaceutical ingredients (APIs) intended for human use. Arguably, the P‐gp status of drugs intended for canine patients is equally, if not more, important.
Neal S. Burke, Katrina L. Mealey
wiley   +1 more source

Relevance of pharmacogenomics for developing countries in Europe : implementation in the Maltese population [PDF]

, 2012
Pharmacogenomics is a promising new discipline that can realize personalized treatment for patients suffering from many common diseases, particularly those with multiple treatment modalities.
Borg, Joseph J., Fenech, Anthony G., Grech, Godfrey, Mitropoulos, Konstantinos, Mitropoulou, Christina, Patrinos, George P., Vozikis, Athanassios   +6 more
core  

Functional Characterization of the Cat and Dog Wild‐Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Lisa Siegl, Mies Bethäuser, Daniela Nürnberger, Stefan Oswald, Andreas Moritz, Melanie Hamann, Joachim Geyer   +6 more
wiley   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Polymorphism rs662 (Q192R) of paraoxonase-1 and susceptibility to atherosclerosis of the coronary arteries

Archives of Medical Science
Introduction The present study concerns a connection of the Q192RPON1 polymorphism with atherosclerosis requiring percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in the Polish population.
Malgorzata Baranska, Mariola Rychlik-Sych, Michał Dudarewicz, Anna Wiktorowska-Owczarek, Jacek Owczarek   +4 more
doaj   +1 more source

The interplay between hepatocyte nuclear factor 4α (HNF4α) and cholesterol sulfotransferase (SULT2B1b) in hepatic energy homeostasis

Liver Research, 2019
The nuclear receptor hepatocyte nuclear factor 4alpha (HNF4α) plays a critical role in the regulation of metabolic homeostasis, including glucose homeostasis.
Yuhan Bi, Youya Wang, Wen Xie
doaj   +1 more source

PB1892: IMATINIB RESISTANCE: THE ROLE OF PHARMACOGENETIC VARIABILITY IN A SOUTH AFRICAN COHORT

, 2022
C. De Long, Faghri February, Nomusa Mashigo, Fatima Bassa, Christie Swanepoel   +4 more
openalex   +1 more source