Metamizole induces voriconazole metabolism and results in subtherapeutic voriconazole concentrations
British Journal of Clinical Pharmacology, Volume 91, Issue 9, Page 2598-2604, September 2025.Aims Voriconazole is extensively metabolized via cytochrome P450 (CYP) enzymes, predominantly CYP2C19 and CYP3A4. Drugs influencing the activity or expression of CYP enzymes can cause clinically relevant changes in the metabolism and voriconazole exposure. Metamizole is known to induce CYP3A4 and CYP2C19.
Simone D. Baan +3 more
wiley +1 more source
Association of TNF and TLR2 genes with blood parameter levels in Mexican patients with schizophrenia
BMC PsychiatryBackground Clinical and genetic studies have suggested that immune dysregulation and neuroinflammation are involved in the pathogenesis of schizophrenia.
Héctor Cabello-Rangel +5 more
doaj +1 more source
Navigating Pharmacogenomic Testing in Practice: Who to Test and When to Test
Clinical Pharmacology &Therapeutics, Volume 118, Issue 3, Page 561-566, September 2025.There is increasing attention on the clinical utility and value of pharmacogenetic (PGx) testing to individualize medication management. Most clinical practice guidelines from medical professional societies do not recommend routine PGx testing, with a few key exceptions.
James M. Stevenson +4 more
wiley +1 more source
Joint meeting with the British Pharmacological Society and the Pharmacological and Clinical Pharmacological Societies of Canada, University of Bath, Symposium on Pharmacogenetics, 12 July 1996 [PDF]
, 1996 Robert Rangno, Peter N. Bennett
openalex +1 more source
MedComm, Volume 6, Issue 9, September 2025.In this study, we found the close proximity of NUDT15 and RB1 in terms of chromosome location and exploited the fact that NUDT15 deficiency induces 6MP‐related adverse drug reactions, thus providing a possible collateral lethality (a specific type of synthetic lethality) strategy to treat RB1‐deficient tumors (created with www.biorender.com).
Tao Zhou +21 more
wiley +1 more source
The research agenda in pharmacogenetics and biological sample collections—a view from the Wellcome Trust [PDF]
, 2000 Patricia Spallone, Tom Wilkie
openalex +1 more source
Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light
Medicinal Research Reviews, Volume 45, Issue 5, Page 1407-1422, September 2025.ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva +5 more
wiley +1 more source
PLANTS, PEOPLE, PLANET, Volume 7, Issue 5, Page 1485-1497, September 2025.Future research and development of biological materials for foods, feeds, fibres, materials and medicines will increasingly rely on information and knowledge using Artificial Intelligence (AI) applications for detecting patterns to make useful decisions.
Charles Lawson +2 more
wiley +1 more source
Clinical trials in pharmacogenetics and pharmacogenomics: Methods and applications [PDF]
, 2000 Patrice Rioux
openalex +1 more source
Acta Anaesthesiologica Scandinavica, Volume 69, Issue 8, September 2025.ABSTRACT Introduction Propofol is commonly used in procedural sedation in oncology due to its rapid sedative effect and favorable recovery profile. However, several preclinical and clinical studies have demonstrated a dose‐dependent neurotoxic effect of this drug.
Domenica Squillaci +8 more
wiley +1 more source