Results 141 to 150 of about 52,343 (282)
Molecular MedicineBackground Patient-derived xenograft (PDX) is currently considered a preferred preclinical model to evaluate drug sensitivity, explore drug resistance mechanisms, and select individualized treatment regimens.
Xiaoqing Wang +7 more
doaj +1 more source
The challenge of pharmacogenetics and pharmacogenomics [PDF]
, 2000 Robert Snedden
openalex +1 more source
British Journal of Pharmacology, Volume 182, Issue 18, Page 4262-4280, September 2025.Abstract Background and Purpose The increasing number of cancer survivors has caused growing concern over chemotherapy‐induced cardiotoxicity. This study aimed to investigate a novel human model of cardiotoxicity and explore cardioprotection. Experimental Approach Living myocardial slices (LMS) were obtained from explanted end‐stage heart failure ...
Jort S. A. van der Geest +15 more
wiley +1 more source
Hepatology CommunicationsBackground:. The prevalence of NAFLD is rapidly increasing. NAFLD can progress to NASH, fibrosis, cirrhosis, and HCC, which will soon become the main causes of liver transplantation.
Sander van Riet +4 more
doaj +1 more source
Clinical and Translational Science, Volume 18, Issue 9, September 2025.ABSTRACT Tacrolimus is an immunosuppressive agent with difficult dosing due to a narrow therapeutic index and large interpatient pharmacokinetic variability, for which CYP3A5 variation plays a role. Tacrolimus/CYP3A5 pharmacogenetic guidelines exclude liver transplant patients with a donor/recipient CYP3A5 mismatch. We sought to determine the influence
Eda Eken +7 more
wiley +1 more source
Acta Pharmaceutica Sinica BSulfation is a crucial and prevalent conjugation reaction involved in cellular processes and mammalian physiology. 3′-Phosphoadenosine 5′-phosphosulfate (PAPS) synthase 2 (PAPSS2) is the primary enzyme to generate the universal sulfonate donor PAPS.
Pengfei Xu +9 more
doaj +1 more source