Results 151 to 160 of about 88,087 (318)
Sulphonylurea efficacy and end‐organ outcomes in the management of HNF4A‐MODY
Diabetic Medicine, EarlyView.Abstract Aims Sulphonylurea agents are typically used to treat HNF4A‐MODY based on the pharmacogenetic aetiology of the condition, although limited evidence exists in the literature for this practice. The aims of this study were to determine the efficacy of sulphonylurea drugs during follow‐up, to explore the role of adjunctive therapies in this cohort
M. T. Crowley +8 more
wiley +1 more source
Precision medicine in cutaneous melanoma—A comprehensive review
Journal of the European Academy of Dermatology and Venereology, EarlyView.Precision medicine tailors treatment to each patient, beginning with detailed diagnostics. In melanoma, it has advanced considerably: Some methods are in practice and guidelines, while others are commercially available but not routine. This review highlights current and emerging approaches, including molecular profiling, imaging, biomarkers and AI ...
Markus Reitmajer, Lukas Flatz
wiley +1 more source
Pharmacogenetics of tamoxifen in breast cancer patients of African descent: Lack of data
Clinical and Translational ScienceTamoxifen, a selective estrogen receptor modulator, is used to treat hormone receptor‐positive breast cancer. Tamoxifen acts as a prodrug, with its primary therapeutic effect mediated by its principal metabolite, endoxifen. However, tamoxifen has complex
Bianca Kruger +3 more
doaj +1 more source
PERSONALIZED PHARMACOTHERAPY IN PSYCHIATRY [PDF]
, 2009 The hypothesis of each individual being special and different leading to heterogenity of diseases sets the ground for the concept of personalized medicine. Personalized psychiatry follows the principles of personalized medicine.
Anamarija Petek, Pavo Filaković
core +1 more source
Journal of the American Geriatrics Society, EarlyView.This graphical abstract illustrates the annual prevalence of exposure to CPIC Level A drugs among older adults, categorized by type of pharmacogenetic recommendation. Data are presented per 1000 older individuals (A) and per 1000 prescriptions (B).
Zinan Zhao +11 more
wiley +1 more source
Insights from Bibliometric Analysis of Epilepsy Research in Morocco between 1969 and 2024
Psychiatry InternationalEpilepsy is a critical neurological condition characterized by the disturbance of the excitatory neuron network, resulting in recurrent seizures. It is a serious health problem requiring intensive attention.
Abdelaziz Zennati +2 more
doaj +1 more source
Pediatric Anesthesia, EarlyView.ABSTRACT Background Propofol is a commonly used intravenous sedative and general anesthetic, with rapid onset and short duration of action. It has a narrow therapeutic index and significant interindividual variability in dosing requirements, which may elevate risks of its use, particularly in children.
Lindy Moxham +4 more
wiley +1 more source
Pediatric Anesthesia, EarlyView.ABSTRACT Background Clonidine and midazolam are routinely used in the pediatric intensive care unit for pain and sedation management, but target concentration and optimal dose are poorly defined for both drugs. The CloSed study is a multicenter, double‐blind, randomized, active‐controlled noninferiority trial with a 1:1 randomization between clonidine ...
Maddlie Bardol +22 more
wiley +1 more source
Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics. [PDF]
, 2020 Do, Thao P +7 more
core +2 more sources