Results 161 to 170 of about 88,087 (318)

Association of TNF and TLR2 genes with blood parameter levels in Mexican patients with schizophrenia

BMC Psychiatry
Background Clinical and genetic studies have suggested that immune dysregulation and neuroinflammation are involved in the pathogenesis of schizophrenia.
Héctor Cabello-Rangel, Carlo Esteban Sotelo-Ramírez, Joanna Jiménez-Pavon, Marco Antonio Sanabrais-Jiménez, Pamela Morales-Cedillo, Beatriz Camarena   +5 more
doaj   +1 more source

Joint meeting with the British Pharmacological Society and the Pharmacological and Clinical Pharmacological Societies of Canada, University of Bath, Symposium on Pharmacogenetics, 12 July 1996 [PDF]

, 1996
Robert Rangno, Peter N. Bennett
openalex   +1 more source

Maternal Sirolimus Treatment Reverses Cardiac Rhabdomyoma‐Induced Hydrops Fetalis in a Twin Gestation With Tuberous Sclerosis Complex

American Journal of Medical Genetics Part A, Volume 197, Issue 11, November 2025.
ABSTRACT Cardiac rhabdomyomas are often the presenting sign of tuberous sclerosis complex (TSC). Prior reports have shown that maternal sirolimus treatment can reduce rhabdomyomas. We used maternal sirolimus to reverse hydrops fetalis due to a massive cardiac rhabdomyoma in a twin gestation.
David M. Ritter, Kristin Schneider, Nkiru Ezeakudo, Darcy A. Krueger, Tomoyuki Mizuno, Timothy K. Knilans, David N. Franz   +6 more
wiley   +1 more source

Recurrent fexuprazan‐induced liver injury following unintentional re‐exposure

British Journal of Clinical Pharmacology, Volume 91, Issue 11, Page 3266-3271, November 2025.
Fexuprazan, a potassium‐competitive acid blocker, is increasingly used for the treatment of gastroesophageal reflux disease in South Korea. While generally well tolerated, data regarding its hepatotoxic potential are scarce. We report a case of idiosyncratic drug‐induced liver injury in a 61‐year‐old woman following 2 months of fexuprazan therapy.
Sook Jin Seong, O Seong Kweon, Young‐Ran Yoon, Yu Kyung Kim, Yoo Na Kang, Se Young Jang   +5 more
wiley   +1 more source

Positive effects of methylphenidate on hyperactivity are moderated by monoaminergic gene variants in children with autism spectrum disorders. [PDF]

, 2014
Methylphenidate (MPH) reduces hyperactive-impulsive symptoms common in children with autism spectrum disorders (ASDs), however, response and tolerability varies widely.
Aman, MG, Arnold, LE, Badashova, KK, Chuang, SZ, Davies, M, McCracken, JT, McDougle, CJ, Nurmi, EL, Posey, DJ, Scahill, L, Shah, B, Tierney, E, Vitiello, B, Whelan, F   +13 more
core  

Pharmacogenetics of clozapine response [PDF]

, 2000
Johannes Schumacher, Thomas G. Schulze, Thomas F. Wienker, Marcella Rietschel, Markus M. Nöthen   +4 more
openalex   +1 more source

Real‐world study on fluoropyrimidine‐related toxicity outcomes in cancer patients with select DPYD variant alleles that received DPYD genotype‐guided dosing

International Journal of Cancer, Volume 157, Issue 9, Page 1898-1911, 1 November 2025.
What's new? Fluoropyrimidines, a key component of chemotherapy regimens for a variety of solid tumors, can cause severe toxicity. Patients who have specific genetic variants in the DPYD gene, which encodes an enzyme that inactivates fluoropyrimidines, have increased susceptibility to this toxicity.
Sofía L. J. Peeters, Didier Meulendijks, Zerina Kadric, Sara Ibrovic, Geert‐Jan Creemers, Vanja Milosevic, Matthijs van de Poll, Lieke H. J. Simkens, Birgit A. L. M. Deiman, Hans Gelderblom, Henk‐Jan Guchelaar, Anna M. J. Thijs, Maarten J. Deenen   +12 more
wiley   +1 more source

Apolipoprotein E Genotyping for Pharmacogenetic Purposes in Alzheimer's Disease: Emerging Ethical Issues [PDF]

, 2000
Amalia M. Issa, Edward W. Keyserlingk
openalex   +1 more source

Reflections on the Cost of Low-Cost Whole Genome Sequencing: Framing the Health Policy Debate [PDF]

, 2013
The cost of whole genome sequencing is dropping rapidly. There has been a great deal of enthusiasm about the potential for this technological advance to transform clinical care.
Biesecker, Barbara, Borry, Pascal, Bubela, Tania, Carroll, June C., Caulfield, Timothy, Cho, Mildred K., Cook-Deegan, Robert, Etchegary, Holly, Evans, Jim, Fishman, Jennifer, Hogarth, Stuart, Joly, Yann, Kato, Kazuto, Lee, Sandra Soo-Jim, McCabe, Christopher, McGuire, Amy, Miller, Fiona A., Ossorio, Pilar, Pullman, Daryl, Ravitsky, Vardit, Rothenberg, Karen H., Rousseau, Francois, Sankar, Pamela, Szego, Michael J., Ungar, Wendy J., Wilson, Brenda   +25 more
core   +1 more source

The research agenda in pharmacogenetics and biological sample collections—a view from the Wellcome Trust [PDF]

, 2000
Patricia Spallone, Tom Wilkie
openalex   +1 more source