Results 171 to 180 of about 88,087 (318)
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.ABSTRACT Introduction Raltegravir, an HIV integrase inhibitor, although generally well tolerated, may cause severe reactions such as drug reaction with eosinophilia and systemic symptoms (DRESS). This syndrome has been associated with impaired drug metabolism, viral reactivation and genetic factors including HLA‐B*53:01.
Cristina Ramos‐Del Moral +10 more
wiley +1 more source
Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy
Nature CommunicationsThe multifaceted chemo-immune resistance is the principal barrier to achieving cure in cancer patients. Identifying a target that is critically involved in chemo-immune-resistance represents an attractive strategy to improve cancer treatment.
Zhangyi Luo +17 more
doaj +1 more source
Induction of Cyp2e1 contributes to asparaginase-induced hepatocyte sensitization to lipotoxicity
Acta Pharmaceutica Sinica BOne of the leading therapies for acute lymphoblastic leukemia (ALL) is the chemotherapeutic agent PEGylated E. coli-derived-l-asparaginase (PEG-ASNase).
Yin Zhu +7 more
doaj +1 more source
Clinical trials in pharmacogenetics and pharmacogenomics: Methods and applications [PDF]
, 2000 Patrice Rioux
openalex +1 more source
Pharmacogenetics for the prescriber
Medicine, 2012 Pharmacogenetics is the study of how genetic factors affect the response to drugs (efficacy, adverse effects). Variation in genes can affect either a drug's pharmacokinetics (how the drug is handled in the body) or its pharmacodynamics (how it interacts with proteins in the body to produce its effects).
openaire +2 more sources
British Journal of Pharmacology, Volume 182, Issue 21, Page 5340-5354, November 2025.Background and Purpose Chemotherapeutic treatment for colorectal cancer (colorectal cancer) allows for increased patient overall survival. However, current therapeutic regimens are often associated with the development of adverse drug reactions, which represent a morbidity, mortality and economic issue.
Ana Rita Simoes +20 more
wiley +1 more source
Pharmacogenetics of catechol-O-methyltransferase: Frequency of low activity allele in a Ghanaian population [PDF]
, 2000 Margaret‐Mary Ameyaw +4 more
openalex +1 more source
Pharmacogenetics and the Blood–Brain Barrier: A Whirlwind Tour of Potential Clinical Utility
Future PharmacologyGenetic factors influence medication response (pharmacogenetics), affecting the pharmacodynamics and pharmacokinetics of many medicaments used in clinical care.
David R. Skvarc +5 more
doaj +1 more source
A population-based study of glutathione-S-transferase M1, T1 and P1 genotypes [PDF]
, 2008 A retrospective study on healthy, unrelated subjects was conducted in order to estimate population glutathione-S-transferases (GST) genotype frequencies in Slovak population of men and compare our results with already published data (GSEC project)^1^.
Duš +6 more
core +1 more source