Results 11 to 20 of about 88,087 (318)
British Medical Bulletin, 1999 Inter-individual variability in drug response is a major clinical problem. Adverse drug reactions (ADRs) are common, are responsible for a number of debilitating side effects following drug therapy and are a significant cause of death. It is now clear that much of the observed variability in drug response has a genetic basis, arising as a result of ...
Wolf, C. Roland, Smith, Gillian
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Pharmacogenetics of Antidepressants [PDF]
Frontiers in Pharmacology, 2011 Up to 60% of depressed patients do not respond completely to antidepressants (ADs) and up to 30% do not respond at all. Genetic factors contribute for about 50% of the AD response. During the recent years the possible influence of a set of candidate genes as genetic predictors of AD response efficacy was investigated by us and others.
Crisafulli C +6 more
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Pharmacogenetics of osteoporosis [PDF]
Best Practice & Research Clinical Endocrinology & Metabolism, 2010 Osteoporosis is a complex bone disorder with a strong genetic basis. The genetics of osteoporosis encompasses two main areas: genetics of disease susceptibility and pharmacogenetics of drug response. The former has been widely studied in the past few decades, while the latter is still largely untouched.
MARINI, FRANCESCA, BRANDI, MARIA LUISA
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CYP2D6 pharmacogenetics and phenoconversion in personalized medicine
Expert Opinion on Drug Metabolism & Toxicology, 2022 Introduction CYP2D6 contributes to the metabolism of approximately 20–25% of drugs. However, CYP2D6 is highly polymorphic and different alleles can lead to impacts ranging from null to increase in activity.
N. A. Nahid, Julie A. Johnson
semanticscholar +1 more source
Pharmacogenomic testing and its future in community pharmacy [PDF]
, 2020 Although it is common to see pharmacogenomic testing used North America and Australia, it is not yet part of practice in the UK. With the promise of genomic screening becoming part of the NHS, pharmacists must equip themselves with a knowledge of how the
Wright, David, Youssef, Essra
core +1 more source
Pharmacogenetics of Direct Oral Anticoagulants: A Systematic Review
Journal of Personalized Medicine, 2021 Dabigatran, rivaroxaban, apixaban, edoxaban, and betrixaban are direct oral anticoagulants (DOACs). Their inter-individual variability in pharmacodynamics and pharmacokinetics (transport and metabolism) is high, and could result from genetic ...
Johanna Raymond +6 more
semanticscholar +1 more source
Moving Pharmacogenetics Into Practice: It’s All About the Evidence!
Clinical pharmacology and therapy, 2021 The evidence for pharmacogenetics has grown rapidly in recent decades. However, the strength of evidence required for the clinical implementation of pharmacogenetics is highly debated.
Jasmine A. Luzum +5 more
semanticscholar +1 more source
Pharmacogenetics: Knowledge assessment amongst Syrian pharmacists and physicians
BMC Health Services Research, 2021 Background Pharmacogenetics targets genetic variations that influence drug response. It is relatively a new science that has not been vastly employed in most developing countries including Syria. Therefore we aimed at evaluating the depth of knowledge in
Lina Albitar, Ghalia Abou Alchamat
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Human Molecular Genetics, 2001 Pharmacogenetics is the variability of drug response due to inherited characteristics in individuals. Drug metabolizing enzymes have been studied for decades, first as chemical reactions and, more recently, as specific polymorphisms of known molecules.
Aoife L. McCarthy
openalex +4 more sources
Frontiers in Pharmacology, 2020 Human leukocyte antigen (HLA) class I and II are known to have association with severe cutaneous adverse reactions (SCARs) when exposing to certain drug treatment. Due to genetic differences at population level, drug hypersensitivity reactions are varied,
Patompong Satapornpong +23 more
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