Results 21 to 30 of about 52,343 (282)
From pharmacogenetics to pharmaco-omics: Milestones and future directions
HGG Advances, 2022 The origins of pharmacogenetics date back to the 1950s, when it was established that inter-individual differences in drug response are partially determined by genetic factors.
Chiara Auwerx +3 more
doaj +1 more source
Pharmacogenetics at scale: An analysis of the UK Biobank
bioRxiv, 2020 Pharmacogenetics (PGx) studies the influence of genetic variation on drug response. Clinically actionable associations inform guidelines created by the Clinical Pharmacogenetics Implementation Consortium (CPIC), but the broad impact of genetic variation ...
G. McInnes +5 more
semanticscholar +1 more source
Some aspects of genetics and pharmacogenetics understanding by pharmacy students in Ukraine
Egyptian Journal of Medical Human Genetics, 2015 Background: Prescription and administration of drugs are still carried out without taking into consideration the individual’s needs of a particular patient on the post-Soviet territory.
O.V. Filiptsova +2 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2022 Combination of passive targeting with active targeting is a promising approach to improve the therapeutic efficacy of nanotherapy. However, most reported polymeric systems have sizes above 100 nm, which limits effective extravasation into tumors that are
Pearl Moharil +12 more
doaj +1 more source
Clinical and Translational Science, 2019 Translating CYP2D6 genotype to metabolizer phenotype is not standardized across clinical laboratories offering pharmacogenetic (PGx) testing and PGx clinical practice guidelines, such as the Clinical Pharmacogenetics Implementation Consortium (CPIC) and ...
K. Caudle +11 more
semanticscholar +1 more source
Journal of Clinical Medicine, 2021 The implementation of clinical pharmacogenetics in daily practice is limited for various reasons. Today, however, it is a discipline in full expansion.
P. Zubiaur +7 more
semanticscholar +1 more source
The Oncologist, EarlyView., 2021 Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi +21 more
wiley +1 more source
BMC Pregnancy and Childbirth, 2017 Background Pharmacogenetics is an emerging field currently being implemented to improve safety when prescribing drugs. While many women who take drugs during pregnancy would likely benefit from such personalized drug therapy, data is lacking on the ...
Aizati N. A. Daud +7 more
doaj +1 more source
Developmental Pharmacogenetics of CYP2D6 in Chinese Children: Loratadine as a Substrate Drug
Frontiers in Pharmacology, 2021 Objective: The elucidation of CYP2D6 developmental pharmacogenetics in children has improved, however, these findings have been largely limited to studies of Caucasian children.
Qian Li +12 more
doaj +1 more source
Clinical pharmacology and therapy, 2019 Thiopurine methyltransferase (TPMT) activity exhibits a monogenic codominant inheritance and catabolizes thiopurines. TPMT variant alleles are associated with low enzyme activity and pronounced pharmacologic effects of thiopurines.
M. Relling +14 more
semanticscholar +1 more source