Results 131 to 140 of about 53,742 (236)

Predicting drug response of tumors from integrated genomic profiles by deep neural networks

, 2018
The study of high-throughput genomic profiles from a pharmacogenomics viewpoint has provided unprecedented insights into the oncogenic features modulating drug response.
Chen, Hung-I Harry, Chen, Yidong, Chiu, Yu-Chiao, Gorthi, Aparna, Huang, Yufei, Wang, Li-Ju, Zhang, Songyao, Zhang, Tinghe   +7 more
core   +1 more source

Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley   +1 more source

Decoding temporal heterogeneity in NSCLC through machine learning and prognostic model construction

World Journal of Surgical Oncology
Background Non-small cell lung cancer (NSCLC) is a prevalent and heterogeneous disease with significant genomic variations between the early and advanced stages. The identification of key genes and pathways driving NSCLC tumor progression is critical for
Junpeng Cheng, Meizhu Xiao, Qingkang Meng, Min Zhang, Denan Zhang, Lei Liu, Qing Jin, Zhijin Fu, Yanjiao Li, Xiujie Chen, Hongbo Xie   +10 more
doaj   +1 more source

Use of Drugs With Actionable Pharmacogenetic Biomarkers and Possible Prescribing Changes Among Older People

Journal of the American Geriatrics Society, EarlyView.
This graphical abstract illustrates the annual prevalence of exposure to CPIC Level A drugs among older adults, categorized by type of pharmacogenetic recommendation. Data are presented per 1000 older individuals (A) and per 1000 prescriptions (B).
Zinan Zhao, Yuxuan Zhao, Xiaowen Hu, Xue Wang, Gengchen Wang, Xinyi Zhang, Wenliang Dong, Luwen Shi, Xiaodong Guan, Christine Y. Lu, Pengfei Jin, Xiaoyan Nie   +11 more
wiley   +1 more source

Novel Humanized Mouse Model for Steroid‐Resistant Asthma

Allergy, EarlyView.
Shiho Yamada, Shuichiro Maruoka, Shota Toyoshima, Yusuke Kurosawa, Ryosuke Ozoe, Yutaka Kozu, Kenji Mizumura, Yoshimichi Okayama, Ryoji Ito, Yasuhiro Gon   +9 more
wiley   +1 more source

Making the Old New Again Through the Process of Recombinant Innovation

Journal of Product Innovation Management, EarlyView.
ABSTRACT Academic Summary Recombinant innovation—the process through which atypical and unexpected combinations of knowledge generate novel outcomes—is a critical driver of organizational distinctiveness and market transformation. While prior research has focused on firm‐ and industry‐level mechanisms, less attention has been given to multilevel ...
Vittoria Magrelli, Josip Kotlar, Alfredo De Massis, Federico Frattini, Antonio Messeni Petruzzelli   +4 more
wiley   +1 more source

Tezepelumab Targeting Thymic Stromal Lymphopoietin Enhances Steroid Sensitivity in Patients With Severe Asthma

Allergy, EarlyView.
Keita Hirai, Sekiko Uehara, Toshihiro Shirai, Taisuke Akamatsu, Kunihiko Itoh   +4 more
wiley   +1 more source

Cannabis‐Derived Compounds Against Plasmodium sp.: A Systematic Review of Preclinical Studies

Tropical Medicine &International Health, EarlyView.
ABSTRACT Objective This study aims to evaluate preclinical studies on the effects and toxicity of cannabis‐derived compounds against Plasmodium sp. Methods A literature search was conducted in Web of Science, PubMed, Scopus and LILACS databases until December 2024. Studies that assessed the activity or toxicity of cannabis against Plasmodium sp.
Tácio de Mendonça Lima, Luann Wendel Pereira de Sena, Ana Carolina Corrêa de Sousa, Gabriel Rodrigues Martins de Freitas, Inajara Rotta, Marília Berlofa Visacri   +5 more
wiley   +1 more source

Mechanisms of organotropism in breast cancer and predicting metastasis to distant organs using deep learning

Discover Oncology
Background Metastasis, the spread of cancer cells from the primary tumor to distant organs, is the leading cause of mortality in cancer patients. This process often exhibits a preference for specific organs, a phenomenon known as tumor organotropism ...
Meizhu Xiao, Zhijin Fu, Yanjiao Li, Min Zhang, Denan Zhang, Lei Liu, Qing Jin, Xiujie Chen, Hongbo Xie   +8 more
doaj   +1 more source

Clinical significance and immune microenvironment association of cuproptosis‐related genes in pan‐cancer

Experimental Physiology, EarlyView.
Abstract Recent studies highlight the important roles of cuproptosis in cancer cells. However, the roles of the cuproptosis‐related genes (CRGs) in different cancers are still not fully understood. Comprehensive analysis was performed using open‐source bioinformatic platforms to disclose the expression profiles, prognostic significance, genomic and ...
Xinyu Ge, Kaijing Wang, Tian Zhao, Jinyi Wang, Jie Liu, Zhengliang Sun, Zhengjun Chai, Wen Zhang, Chengbao Li, Yan Xu, Guohan Chen   +10 more
wiley   +1 more source