Results 151 to 160 of about 74,509 (297)

Glycaemic responses to metformin monotherapy by SNP clusters in patients with type 2 diabetes

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims This study retrospectively investigates the association between polygenic risk scores (PRS) derived from SNP clusters and glycaemic response to metformin in patients with newly diagnosed T2D. Materials and Methods Utilizing a dataset from the Taiwan Precision Medicine Initiative, we evaluated alterations in fasting glucose (FBG) and ...
Wayne Huey‐Herng Sheu, Chun‐Yi Lee, Yi‐Wen Wang, Cai‐Sian Liao, Tzu‐Hung Hsiao, Ken Suzuki, Konstantinos Hatzikotoulas, Andrew P. Morris, the Type 2 Diabetes Global Genetics Initiative, Yii‐Der Ida Chen, Jerome I. Rotter   +10 more
wiley   +1 more source

Review on application and development of pharmacogenomics of adverse drug reactions

Journal of Holistic Integrative Pharmacy
Adverse drug reactions (ADRs) are a significant public health issue, contributing substantially to patient morbidity and mortality. The growing accessibility of genomic technologies has greatly advanced our understanding of the genetics underlying ADRs ...
Hongyu Bi, Jun Zhu, Yuanxuan Cai, Xiaofang Shangguan, Zherui Chen, Maimoon Shihab Ahmed, Rui Huang   +6 more
doaj   +1 more source

Pharmacogenomics: The promise of personalized medicine

, 2000
Laviero Mancinelli, Maureen Cronin, Wolfgang Sadée   +2 more
openalex   +2 more sources

Pharmacogenetics, pharmacogenomics and airway disease [PDF]

, 2001
Ian P. Hall
openalex   +1 more source

Breaking the paradigm: Dr Insight empowers signature-free, enhanced drug repurposing [PDF]

, 2019
Motivation: Transcriptome-based computational drug repurposing has attracted considerable interest by bringing about faster and more cost-effective drug discovery.
Baldwin, Nicole E., Chan, Jinyan, Gu, Jinghua, Turner, Jacob A., Wang, Xuan   +4 more
core   +1 more source

Skin‐Derived PGD2 Promotes Antigen‐Specific IgE Production via CRTH2 Signaling

Allergy, EarlyView.
Misato Kida, Tatsuro Nakamura, Shingo Maeda, Nanae Nagata, Hirofumi Enomoto, Takahisa Murata   +5 more
wiley   +1 more source

Electrical stimulation of stem cell–derived human neural networks for evaluating anti‐seizure medications

Epilepsia, EarlyView.
Abstract Objective Current preclinical epilepsy drug screening relies on animal models that poorly reflect human neurophysiology, leading to high failure rates in clinical translation. We aimed to establish a human in vitro model using human‐induced pluripotent stem cell (hiPSC)–derived cortical neurons cultured on multielectrode arrays (MEAs), capable
Joshua Nicholls, Jinchao Gu, Zhibin Chen, Zikou Liu, Ana Antonic‐Baker, Muhammad Shahid Javaid, Eliza Moore, Hailin Zhu, Afaf Altalhi, David K. Wright, Huseyin Sumer, Terence J. O'Brien, Patrick Kwan, Ben Rollo   +13 more
wiley   +1 more source

Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley   +1 more source

Investigation of community pharmacists’ knowledge and attitudes of pharmacogenomics testing: implication for improved pharmacogenomic testing practice

Human Genomics
Background Community pharmacists must be well-equipped to advance pharmacogenomics services. Nevertheless, limited data is available regarding pharmacists' knowledge and attitudes toward pharmacogenomics testing.
Azza Ramadan, Anan S. Jarab, Ahmad Z. Al Meslamani   +2 more
doaj   +1 more source

Assessing the cost-effectiveness of pharmacogenomics

, 2000
David L. Veenstra, Mitchell K. Higashi, Kathryn A. Phillips   +2 more
openalex   +2 more sources