Results 161 to 170 of about 53,742 (236)

The association between white blood cell count and relative risk of non-small cell lung cancer

Discover Oncology
Background High abundance of eosinophils has been proved to associated with favorable disease progression in non-small cell lung cancer (NSCLC) in the previous observational studies, but the causal relationship remains unclear. It is also unclear whether
Xiao Yang, Wenyi Liu, Jiaqi Wang, Weifeng Xia, Lanxiang Wu   +4 more
doaj   +1 more source

Mirogabalin for Treatment of Neuropathic Pain and Associated Sleep Interference: An Updated Meta‐Analysis

European Journal of Pain, Volume 29, Issue 10, November 2025.
ABSTRACT Background and Objective Neuropathic pain (NeP) is a common and debilitating consequence of several neurological conditions. Gabapentinoids are used on a large scale for the treatment of both central and peripheral NeP. Mirogabalin, a novel gabapentinoid, has been proposed as a promising treatment for this condition; however, its efficacy and ...
Rafael Batista João, Jilly Octoria Tagore Chan, André Batista João, Luísa Mendes Araújo, Julyana Medeiros Dantas   +4 more
wiley   +1 more source

Pharmacogenomics and Therapeutic Target Validation in Cerebral Vasospasm

, 2000
Toshio Tanaka, Yuhei Nishimura, Hiroshi Tsunoda, Michiko Naka   +3 more
openalex   +1 more source

Pharmacogenomics: The implementation phase [PDF]

, 2002
Wolfgang Sadée
openalex   +1 more source

Mendelian Randomization and Bioinformatics Analysis Reveal the Potential Protective Role of Metformin in Primary Liver Cancer

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
Using two‐sample Mendelian randomization and bioinformatics, this study found metformin associated with reduced primary liver cancer (PLC) risk (p = 0.026), without links to HCC/ICC. Key genes (e.g., DDX52, KIF11) and pathways (cGMP‐PKG signaling, fatty acid metabolism) were identified.
Yongxin Ma, Jiaojiao Qi, Zhiqiang Chen, Yubo Zhang, Kejun Liu, Jiaxin Suo, Bendong Chen, Yang Bu   +7 more
wiley   +1 more source

Real‐world study on fluoropyrimidine‐related toxicity outcomes in cancer patients with select DPYD variant alleles that received DPYD genotype‐guided dosing

International Journal of Cancer, Volume 157, Issue 9, Page 1898-1911, 1 November 2025.
What's new? Fluoropyrimidines, a key component of chemotherapy regimens for a variety of solid tumors, can cause severe toxicity. Patients who have specific genetic variants in the DPYD gene, which encodes an enzyme that inactivates fluoropyrimidines, have increased susceptibility to this toxicity.
Sofía L. J. Peeters, Didier Meulendijks, Zerina Kadric, Sara Ibrovic, Geert‐Jan Creemers, Vanja Milosevic, Matthijs van de Poll, Lieke H. J. Simkens, Birgit A. L. M. Deiman, Hans Gelderblom, Henk‐Jan Guchelaar, Anna M. J. Thijs, Maarten J. Deenen   +12 more
wiley   +1 more source

Science of omics: a molecular space odyssey

Experimental Physiology, EarlyView.
Salomé Coppens, Christophe Hirtz, Margaux Vignon, Damian M. Bailey   +3 more
wiley   +1 more source

Utilization of Proteomic Measures for Early Detection of Drug Benefits and Adverse Effects

The Journal of Clinical Pharmacology, Volume 65, Issue 11, Page 1460-1473, November 2025.
Abstract Recognition of benefits and adverse effects of therapies in earlier clinical trial phases could improve the safety, efficiency, and cost of clinical trials. Using four clinical trials representing a diverse set of diseases and drug classes (EXSCEL: exenatide/GLP‐1 RA, SUGAR‐DM‐HF: empagliflozin/SGLT2i, PRADA: epirubicin/anthracycline, and ...
Jessica Chadwick, Colin Berry, Meredith A. Carpenter, Geeta Gulati, Siri Lagethon Heck, Michael A. Hinterberg, Rury R. Holman, Matthew M.Y. Lee, Torbjørn Omland, Clare Paterson, Mark C. Petrie, Naveed Sattar, Svati H. Shah, Sama Shrestha, Harald Sourij, Emma V Troth, Victoria Vinje, Stephen A. Williams   +17 more
wiley   +1 more source

Development and Application of an Algorithm for Statin‐Induced Myopathy Based on Electronic Health Record‐Derived Structured Elements

Pharmacoepidemiology and Drug Safety, Volume 34, Issue 11, November 2025.
ABSTRACT Purpose Considering the non‐specific nature of muscle symptoms, studies of statin‐induced myopathy (SIM) in electronic health records require accurate algorithms that can reliably identify true statin‐causing cases. Prior algorithms were constructed in study populations that preclude broad applicability.
Akinyemi Oni‐Orisan, Meng Lu, Jonathan A. Peng, Ronald M. Krauss, Carlos Iribarren, Marisa W. Medina   +5 more
wiley   +1 more source

High-throughput techniques for analyzing SNPs and application of SNPs to pharmacogenomics.

, 2000
Akito Tanoue
openalex   +2 more sources