Results 181 to 190 of about 39,211 (299)

Machine Learning–Augmented Precision Dosing: Integrating Pharmacokinetic Modeling With Clinical Decision Support

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 11, November 2026.
ABSTRACT Inter‐individual variability in drug exposure can lead to ineffective therapy or toxicity, particularly in vulnerable patients. Routine model‐informed precision dosing (MIPD) relies mainly on population pharmacokinetic (PopPK) models, Bayesian forecasting, and therapeutic drug monitoring (TDM).
Yunmeng Pang, Bingqi Zhang, Zhiqiu He, Yuliu Li, Jiaxin Yu, Wei Zuo   +5 more
wiley   +1 more source

Pharmacogenomics-guided therapy for essential hypertension: a multi-center randomized controlled open-label trial. [PDF]

Front Cardiovasc Med
Wu S, Liu W, Chen L, Xu Y, Jin J, Chen F, Li J, Hu W, Wu J, Cai Y, Huang Z, Chai X, Shi X, Luo Y, Zeng G, Zeng H, Chen Z, Guo F, Wang L, Wu M, Qu Z, Wang Y, Peng D.   +22 more
europepmc   +1 more source

Genetic and Clinical Determinants of Variation in Drug Response in Type 2 Diabetes: Insights From the Scottish and UK Biobank Cohorts

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10780-10794, November 2026.
ABSTRACT Objective Treatment response in type 2 diabetes (T2D) varies widely among individuals. This study aimed to quantify the contributions of clinical characteristics and genetic predisposition as measured through partitioned polygenic risk scores (pPRS) to variation in glycemic response to glucose‐lowering therapies.
S. Garg, R. Kitchen, R. Gupta, L. Donnelly, E. R. Pearson   +4 more
wiley   +1 more source

Gamification in genetics, genomics, and pharmacogenomics education: a bibliometric analysis of research trends, collaboration, and emerging themes (2000-2025). [PDF]

Front Med (Lausanne)
Rahma AT, AlSheryani R, Hatim Khalid Alrabee N, Alderei A, Alharthi A, Alshebli A, Alriyami F, Alzaabi S, Ahmed G, AlMarzooqi FM, Al-Shamsi S.   +10 more
europepmc   +1 more source

Complexity and Pharmacogenomics [PDF]

The Pharmacogenomics Journal, 2002
J, Licinio, M-L, Wong
openaire   +2 more sources

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

Cost-Effectiveness of Pharmacogenomics-Guided Treatment in Cardiovascular Disease: An Umbrella Review. [PDF]

Pharmgenomics Pers Med
Janković SM, Milosavljević M, Stević I, Ašić A, Jusić A, Devaux Y, Belančić A, Bektay MY, Pejčić AV.   +8 more
europepmc   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Introduction. [PDF]

Clin Pharmacol Ther
europepmc   +1 more source

Implementation of a Pharmacogenomic Service in a Pediatric Community Hospital. [PDF]

J Pediatr Pharmacol Ther
Miller D, Trinkman H, John R.
europepmc   +1 more source