Results 21 to 30 of about 74,509 (297)
Platelet pharmacogenomics [PDF]
Journal of Thrombosis and Haemostasis, 2010 Platelet responsiveness to conventional antiplatelet therapy underlies a high interindividual variability influenced by various factors. For instance, antiplatelet therapy does not curtail the expected effects in a relevant number of patients as demonstrated by the occurrence of repeated cardiovascular events including stent thrombosis and/or by ...
Tobias Geisler +3 more
openaire +3 more sources
Clinical application of high throughput molecular screening techniques for pharmacogenomics. [PDF]
, 2011 Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples.
Schrijver, Iris, Wiita, Arun P
core +1 more source
Hepatitis C virus pharmacogenomics in Latin American populations: implications in the era of direct-acting antivirals [PDF]
, 2017 In recent years, great progress has been made in the field of new therapeutic options for hepatitis C virus (HCV) infection. The new direct-acting antiviral agents (DAAs) represent a great hope for millions of chronically infected individuals because ...
Caputo, Mariela +4 more
core +1 more source
Cannabis Pharmacogenomics: A Path to Personalized Medicine
Current Issues in Molecular Biology, 2023 Cannabis and related compounds have created significant research interest as a promising therapy in many disorders. However, the individual therapeutic effects of cannabinoids and the incidence of side effects are still difficult to determine ...
Mariana Babayeva, Zvi G. Loewy
doaj +1 more source
, 2023 Pharmacogenomics is an emerging field that investigates how a person's unique genetic makeup affects their response to medications. By analyzing genetic variations, researchers can identify genetic markers that influence drug metabolism, efficacy, and adverse effects.
openaire +2 more sources
The Lancet, 2019 Genomic medicine, which uses DNA variation to individualise and improve human health, is the subject of this Series of papers. The idea that genetic variation can be used to individualise drug therapy-the topic addressed here-is often viewed as within reach for genomic medicine. We have reviewed general mechanisms underlying variability in drug action,
Dan M, Roden +6 more
openaire +3 more sources
Clinical Pharmacology & Therapeutics, 2011 Pharmacogenomics research is yielding molecular diagnostic tools that can be used to optimize the selection of medications and their doses for individual patients. Given the narrow therapeutic index of most anticancer agents and the serious consequences of undertreatment, cancer chemotherapy is a compelling therapeutic area for translation of ...
S. W. Paugh +5 more
openaire +3 more sources
Toward a clinical practice guide in pharmacogenomics testing for functional polymorphisms of drug-metabolizing enzymes. Gene/drug pairs and barriers perceived in Spain [PDF]
, 2012 The development of clinica lpractice recommendations or guidelines for the clinical use of biomarkers is an issue of great importance withr regard to adverse drug reactions.The poten-tial of pharmacogenomicbiomarkers has been extensively investigated in
Abad Santos, Francisco +18 more
core +4 more sources
Physicians’ pharmacogenomics information needs and seeking behavior: a study with case vignettes
BMC Medical Informatics and Decision Making, 2017 Background Genetic testing, especially in pharmacogenomics, can have a major impact on patient care. However, most physicians do not feel that they have sufficient knowledge to apply pharmacogenomics to patient care. Online information resources can help
Bret S. E. Heale +4 more
doaj +1 more source
Pharmacogenetics : the science of predictive clinical pharmacology [PDF]
, 2014 The study of pharmacogenetics has expanded from what were initially casual family-based clinical drug response observations, to a fully-fledged science with direct therapeutic applications, all within a time-span of less than 60 years. A wide spectrum of
Fenech, Anthony G., Grech, Godfrey
core +1 more source