Results 1 to 10 of about 362,059 (246)
Role of pharmacists in management of patients with thyroid disorders [PDF]
Arhiv za farmaciju, 2022 Thyroid dysfunction is one of the most prevalent endocrine disorders, especially common in female patients. If patients are not diagnosed in time or adequately treated, the patients' quality of life can be significantly impaired and additional health ...
Homšek Ana +3 more
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Concept and utility of population pharmacokinetic and pharmacokinetic/pharmacodynamic models in drug development and clinical practice [PDF]
Arhiv za farmaciju, 2021 Due to frequent clinical trial failures and consequently fewer new drug approvals, the need for improvement in drug development has, to a certain extent, been met using model-based drug development.
Roganović Maša +6 more
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Evaluation of changes in cytochrome P450 2C19 activity in type 2 diabetic rats before and after treatment, by using isolated perfused liver model [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Alteration in drug metabolism is very likely in diabetes mellitus. This study assessed changes in CYP2C19 enzymatic activity in the liver using omeprazole as a probe in the animal model of type II diabetes (T2DM) before and after treatment ...
Navid Neyshaburinezhad +4 more
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Molecules, 2020 Breast milk contains human milk oligosaccharides (HMOs), including sialyllactose (SL). SL is composed of sialic acid and lactose, and is divided into 3′-SL and 6′-SL according to the binding position.
Han Young Eom +2 more
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CPT: Pharmacometrics & Systems Pharmacology, 2021 Renal clearance of many drugs is mediated by renal organic anion transporters OAT1/3 and inhibition of these transporters may lead to drug‐drug interactions (DDIs).
Amais Ahmad +6 more
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CPT: Pharmacometrics & Systems Pharmacology, 2022 P‐glycoprotein (P‐gp) is an efflux transporter that plays an important role in the pharmacokinetics of its substrate, and P‐gp activities can be altered by induction and inhibition effects of rifampicin.
Ryuta Asaumi +4 more
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BDNF-loaded PDADMAC-heparin multilayers: a novel approach for neuroblastoma cell study
Scientific Reports, 2023 Biomaterial science has contributed tremendously to developing nanoscale materials for delivering biologically active compounds, enhancing protein stability, and enabling its therapeutic use.
Maria Dąbkowska +7 more
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Open questions on bioequivalence: the case of cholecalciferol
Italian Journal of Medicine, 2013 Cholecalciferol or vitamin D3 is an endogenous substance with the typical problems of bioavailability/bioequivalence of this class of substances. A previous trial has shown that, if administered orally at a dose of 800-10,000 IU and bioassayed as its 25 ...
Antonio Marzo +2 more
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CPT: Pharmacometrics & Systems Pharmacology, 2023 Simplified physiologically based pharmacokinetic (PBPK) models using estimated tissue‐to‐unbound plasma partition coefficients (Kpus) were previously investigated by fitting them to in vivo pharmacokinetic (PK) data.
Estelle Yau +4 more
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Molecules, 2021 Sialyllactose (SL), an acidic oligosaccharide, has immune-protective effects against pathogens and helps with the development of the immune system and intestinal microorganisms.
Seok-In Jang +4 more
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