Results 11 to 20 of about 865,562 (415)
Fractional Calculus in Pharmacokinetics [PDF]
J Pharmacokinet Pharmacodyn (2018) 45: 107, 2019 We are witnessing the birth of a new variety of pharmacokinetics where non-integer-order differential equations are employed to study the time course of drugs in the body: this is dubbed "fractional pharmacokinetics." The presence of fractional kinetics has important clinical implications such as the lack of a half-life, observed, for example with the ...
Pantelis Sopasakis +3 more
arxiv +2 more sources
Pharmacology Research & Perspectives, 2023 Daprodustat is an oral small molecule hypoxia‐inducible factor (HIF) prolyl hydroxylase inhibitor (PHI) approved in Japan and the United States for the treatment of anemia associated with chronic kidney disease.
Guoying Tai +8 more
doaj +1 more source
Sex differences in pharmacokinetics predict adverse drug reactions in women
Biology of Sex Differences, 2020 Women experience adverse drug reactions, ADRs, nearly twice as often as men, yet the role of sex as a biological factor in the generation of ADRs is poorly understood.
I. Zucker, B. Prendergast
semanticscholar +1 more source
Population Pharmacokinetics and Bayesian Dose Adjustment to Advance TDM of Anti-TB Drugs
Clinical Pharmacokinetics, 2021 Tuberculosis (TB) is still the number one cause of death due to an infectious disease. Pharmacokinetics and pharmacodynamics of anti-TB drugs are key in the optimization of TB treatment and help to prevent slow response to treatment, acquired drug ...
Marieke G. G. Sturkenboom +9 more
semanticscholar +1 more source
Journal of Pharmaceutical Health Care and Sciences, 2021 Background Irinotecan (CPT-11) is clinically known to cause severe diarrhea and gastrointestinal damage. Recently, we have reported that CPT-11-induced gastrointestinal damage is associated with the upregulation of intestinal P-glycoprotein (P-gp ...
Toshiaki Tsuchitani +3 more
doaj +1 more source
Pharmacology Research & Perspectives, 2020 In clinical pharmacology, the free drug hypothesis has been widely applied in the interpretation of the relationship between pharmacokinetics and pharmacodynamics (PK/PD).
Chun Chen +21 more
doaj +1 more source
Scientific Reports, 2020 Oligonucleotide therapeutics use short interfering RNA (siRNA) or antisense oligonucleotide (ASO) molecules to exploit endogenous systems—neutralizing target RNA to prevent subsequent protein translation. While the potential clinical application is vast,
Mai B. Thayer +5 more
doaj +1 more source
Developing a Knowledge Graph Framework for Pharmacokinetic Natural Product-Drug Interactions [PDF]
Journal of Biomedical Informatics 140 (2023) 104341, 2022 Pharmacokinetic natural product-drug interactions (NPDIs) occur when botanical natural products are co-consumed with pharmaceutical drugs. Understanding mechanisms of NPDIs is key to preventing adverse events. We constructed a knowledge graph framework, NP-KG, as a step toward computational discovery of pharmacokinetic NPDIs.
arxiv +1 more source
The pharmacokinetics of amygdalin [PDF]
Archives of Toxicology, 1982 Amygdalin (D-mandelonitrile-beta-D-gentiobioside) is a cyanogenic glycoside claimed to show anti-cancer activity, sold under the incorrect name "Laetrile". For a sensible discussion of its alleged activity and its established toxicity it is necessary that its fate in the organism is known. The pharmacokinetics of amygdalin have been investigated in the
A. Timmerman, M. Olling, A. G. Rauws
openaire +3 more sources
CPT: Pharmacometrics & Systems Pharmacology, 2021 Platelets are produced by hematopoietic stem cells via megakaryocytes in the bone marrow and play a critical role in hemostasis. The aim of this study was to develop a new platelet model based on the thrombopoiesis and platelet life‐cycle by a ...
Ryosuke Shimizu +2 more
doaj +1 more source