Results 231 to 240 of about 628,142 (342)

N^ε-Acryloyllysine Piperazides as Irreversible Inhibitors of Transglutaminase 2: Synthesis, Structure–Activity Relationships, and Pharmacokinetic Profiling

, 2018
Robert Wodtke, Christoph Hauser, Gloria Ruiz‐Gómez, Elisabeth Jäckel, David Bauer, Martin J. Lohse, Alan Wong, Johanna Pufe, Friedrich‐Alexander Ludwig, Steffen Fischer, Sandra Hauser, Dieter Greif, M. Teresa Pisabarro, Jens Pietzsch, Markus Pietsch, Reik Löser   +15 more
openalex   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Correction to: Effect of Renal Impairment on Pharmacokinetics and Safety of Ensitrelvir, a SARS‑CoV‑2 3CL Protease Inhibitor

Infectious Diseases and Therapy
Takayuki Katsube, Safwan Kezbor, Ryosuke Shimizu, Ryuji Kubota   +3 more
doaj   +1 more source

The science of responsible drinking [PDF]

, 2018
Maskell, Peter D.
core  

Pharmacokinetics 101 [PDF]

Paediatrics & Child Health, 2011
openaire   +2 more sources

Ultrasound Controlled‐Release Hydrogel Promotes Diabetic Wound Healing via Neuroimmune Modulation and Synergistic ROS Scavenging

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive hydrogel (MCF@CA) that co‐delivers a neuropeptide (CGRP) and a ROS‐scavenging manganese porphyrin to diabetic wounds. The system restores neuro‐immune communication, reprograms macrophages toward an anti‐inflammatory phenotype, and clears excess ROS, thereby accelerating wound closure and promoting mature ...
Mofan Li, Mengxin Wang, Haonan Wang, Yang Sun, Yongyue Zhang, Shuyu Xu, Tianjiao Zhang, Shiti Shama, Xiaolong Liang, Shumin Wang   +9 more
wiley   +1 more source

Correction: How is Levetiracetam Monotherapy Currently Monitored in Pregnancy? A Systematic Review. [PDF]

Clin Pharmacokinet
Rademaker T, Goo Y, Soh MC, Pasupathy D, Wong C, Bleasel A, Alffenaar JW.   +6 more
europepmc   +1 more source

Population pharmacokinetics

Vojnosanitetski pregled, 2005
Jasmina Milovanovic, Slobodan Jankovic
openaire   +4 more sources

Cytoprotection Concepts for Ischemic Stroke in the Recanalization Era

Advanced Science, EarlyView.
This review provides detailed information on modern cytoprotective strategies for ischemic stroke in the context of recanalization therapies. It derives their rationale based on contemporary knowledge of stroke pathophysiology and discusses the role of advanced imaging approaches as well as concepts for novel clinical trial designs.
Johannes Boltze, Marc Fisher
wiley   +1 more source

Effects of sleeve gastrectomy on rivaroxaban pharmacokinetics, efficacy, and safety. [PDF]

Front Pharmacol
Alqahtani S, Almutairi A, Aldajani F, Basudan M, Alzahrani A, Alenazi M, Alsarhani E, Alsubaie A, Almaghrabi A, Bamehriz F, Alsubaie H, Algahtani F.   +11 more
europepmc   +1 more source