Results 231 to 240 of about 905,269 (391)

Pharmacokinetics of the Aminoglycoside Antibiotic Tobramycin in Humans [PDF]

, 1973
Kurt G. Naber, S. Westenfelder, Paul O. Madsen   +2 more
openalex   +1 more source

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

Exploring the Interaction Between Injection Site and Biological Sex on the Real-world Population Pharmacokinetics of Long-acting Cabotegravir and Rilpivirine in People With HIV. [PDF]

Open Forum Infect Dis
Tan B, John M, Castley A, Williams L, Joyce D, Nolan D, O'Halloran S, Salman S.   +7 more
europepmc   +1 more source

Pharmacokinetics of Amoxicillin: Dosage Nomogram for Patients with Impaired Renal Function [PDF]

, 1979
Guy Humbert, Daniel A. Spyker, J P Fillastre, A Leroy   +3 more
openalex   +1 more source

Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast–Dendritic Cell Crosstalk in Atopic Dermatitis

Advanced Science, EarlyView.
Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Shicong Li, Dihui Xu, Chenyang Zhang, Chunxiu Xiao, Meng Yu, Jiaojiao Wang, Wenyuan Wu, Xiang Lv, Dongping Yuan, Liang Zhang, Min Hong, Jing Zhou, Yang Sun, Hongyue Ma, Yuyu Zhu   +14 more
wiley   +1 more source

Cats and cannabinoids: past, present and future. [PDF]

J Feline Med Surg
Niño Cital S, Wakshlag J, Kennedy A, Tittle D, Petty M.   +4 more
europepmc   +1 more source

Pharmacokinetic Interpretation of Cephradine Levels in Serum After Intravenous and Extravascular Administration in Humans

, 1976
Elisabeth S. Rattie, Peter D. Bernardo, Louis J. Ravin   +2 more
openalex   +1 more source

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Advanced Science, EarlyView.
Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang   +15 more
wiley   +1 more source

Correction: Effect of Hepatic Impairment or Renal Impairment on the Pharmacokinetics of Aficamten. [PDF]

Clin Pharmacokinet
Xu D, Lutz JD, Divanji P, Li J, Benattia Y, Griffith A, Heitner SB, Kupfer S, German P.   +8 more
europepmc   +1 more source

Studies on the Metabolic Fate and the Pharmacokinetics of 5-n-Butyl-1-cyclohexyl-2, 4, 6-trioxoperhydropyrimidine (BCP) in Man. I. Identification of the Metabolites of BCP in Human Urine

, 1971
Takatsuka Yashiki, Tai Matsuzawa, Takao Kondo, Yoshiaki Uda, Takashi Shima, Hiroyuki Mima, Shigeo Senda, Hiroshi Izumi   +7 more
openalex   +2 more sources