Results 21 to 30 of about 865,562 (415)
Frontiers in Pharmacology, 2022 Biowaiver based on the biopharmaceutics classification system (BCS) has been widely used in the global market for the approval of new generic drug products to avoid unnecessary in vivo bioequivalence (BE) studies.
Xian Zhang +7 more
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Molecules, 2022 PSTi8 is a pancreastatin inhibitory peptide that is effective in the treatment of diabetic models. This study investigates the pharmacokinetic (PK) properties of PSTi8 in Sprague Dawley rats, for the first time.
Guru R. Valicherla +8 more
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Antibiotics, 2020 Recent research has found higher levels and longer total exposure of azithromycin, a macrolide antibiotic agent, in the interstitial fluid of the skin than in the plasma. This unique distribution is expected to contribute to its antimicrobial activity at
Shinji Kobuchi +4 more
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Can We Predict Individual Concentrations of Tacrolimus After Liver Transplantation? Application and Tweaking of a Published Population Pharmacokinetic Model in Clinical Practice [PDF]
Therapeutic Drug Monitoring, 2021, 43 (4), pp.490-498, 2023 Background: Various population pharmacokinetic models have been developed to describe the pharmacokinetics of tacrolimus in adult liver transplantation. However, their extrapolated predictive performance remains unclear in clinical practice. The purpose of this study was to predict concentrations using a selected literature model and to improve these ...
arxiv +1 more source
Scientific Reports, 2017 To be effective as a drug, a potent molecule must reach its target in the body in sufficient concentration, and stay there in a bioactive form long enough for the expected biologic events to occur.
Antoine Daina, O. Michielin, V. Zoete
semanticscholar +1 more source
Pharmacology Research & Perspectives, 2020 The pharmacokinetics (PK), metabolism, excretion, mass balance, and tissue distribution of [14C]praliciguat were evaluated following oral administration of a 3‐mg/kg dose in Sprague‐Dawley rats and in a quantitative whole‐body autoradiography (QWBA ...
Ali R. Banijamali +10 more
doaj +1 more source
Cell Death Discovery, 2022 As the modulation of serine/arginine-rich splicing factor 3 (SRSF3) may be therapeutically beneficial to colorectal cancer (CRC) treatment, the identification of novel SRSF3 inhibitors is highly anticipated. However, pharmaceutical agents targeting SRSF3
Yawen Zhang +14 more
doaj +1 more source
Pharmacokinetics and population pharmacokinetics in pediatric oncology [PDF]
Pediatric Blood & Cancer, 2019 AbstractPharmacokinetic research has become increasingly important in pediatric oncology as it can have direct clinical implications and is a crucial component in individualized medicine. Population pharmacokinetics has become a popular method especially in children, due to the potential for sparse sampling, flexible sampling times, computing of ...
Sebastiaan D.T. Sassen +3 more
openaire +4 more sources
Nanomaterials and pharmacokinetics
, 2021 Nanomaterials have outstanding applications in biomedical areas, such as drug delivery agents, nanoparticles-based imaging, magnetic fluid hyperthermia, and tissue regeneration. In the line of extensive development in nanomaterials-aided drug delivery platforms, pharmacokinetic assessments have achieved greater consideration from scientists and ...
Somvanshi, Sandeep B. +4 more
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Pharmacokinetics of Dasatinib [PDF]
Prague Medical Report, 2019 Tyrosine kinase inhibitors have recently become an essential tool in management of chronic myeloid leukaemia (CML). Dasatinib, a representative of those drugs, acts by inhibiting key proteins included in CML development, predominantly Bcr-Abl and Src. Its advantage is that it shows activity in many cases where other agents bring no improvement due to ...
Jana Hořínková +2 more
openaire +4 more sources