Results 21 to 30 of about 628,142 (342)

Preclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia

Pharmacology Research & Perspectives, 2019
MGS0274 besylate is an ester‐based lipophilic prodrug of a metabotropic glutamate (mGlu) 2 and mGlu3 receptor agonist MGS0008 and being developed for the treatment of schizophrenia.
Kohnosuke Kinoshita, Motoki Ochi, Katsuya Iwata, Misako Fukasawa, Jun‐ichi Yamaguchi   +4 more
doaj   +1 more source

Evaluation of dosing strategy for pembrolizumab for oncology indications

Journal for ImmunoTherapy of Cancer, 2017
Background Traditionally, most monoclonal antibodies (mAbs) have been dosed based on body weight because of perceived contribution of body size in pharmacokinetic variability.
Tomoko Freshwater, Anna Kondic, Malidi Ahamadi, Claire H. Li, Rik de Greef, Dinesh de Alwis, Julie A. Stone   +6 more
doaj   +1 more source

Systemic Evaluation on the Pharmacokinetics of Platinum-Based Anticancer Drugs From Animal to Cell Level: Based on Total Platinum and Intact Drugs

Frontiers in Pharmacology, 2020
Cisplatin, carboplatin, and oxaliplatin are the common platinum-based anticancer drugs widely used in the chemotherapeutic treatment of solid tumors in clinic.
Zhiying Qin, Guanghui Ren, Jinjie Yuan, Huili Chen, Yang Lu, Ning Li, Yongjie Zhang, Xijing Chen, Di Zhao   +8 more
doaj   +1 more source

Potency of marbofloxacin for pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida: Comparison of growth media [PDF]

, 2017
Pharmacodynamic properties of marbofloxacin were established for six isolates each of the pig respiratory tract pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida.
Dorey, L, Hobson, S, Lees, P
core   +2 more sources

Comparison of the qCON and qNOX indices for the assessment of unconsciousness level and noxious stimulation response during surgery [PDF]

, 2016
The objective of this work is to compare the performances of two electroencephalogram based indices for detecting loss of consciousness and loss of response to nociceptive stimulation.
Agustí, Mercé, Fontanet, Joan, Gabarrón, Eva, Gambus, Pedro L., Jensen, Erik Weber, Melia, Umberto Sergio Pio, Pineda, Patricia, Souto, Nuria, Vallverdú Ferrer, Montserrat   +8 more
core   +2 more sources

A Whole-Body Physiologically Based Pharmacokinetic Model Characterizing Interplay of OCTs and MATEs in Intestine, Liver and Kidney to Predict Drug-Drug Interactions of Metformin with Perpetrators

Pharmaceutics, 2021
Transmembrane transport of metformin is highly controlled by transporters including organic cation transporters (OCTs), plasma membrane monoamine transporter (PMAT), and multidrug/toxin extrusions (MATEs).
Yiting Yang, Zexin Zhang, Ping Li, Weimin Kong, Xiaodong Liu, Li Liu   +5 more
doaj   +1 more source

Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection

Journal of Pharmaceutical Health Care and Sciences, 2023
Background Tedizolid is a new oxazolidinone antibiotic with high potency for the treatment of infections caused by methicillin-resistant Staphylococcus aureus and other species.
Daisuke Negishi, Okimichi Mitsumatsu, Hiromi Mitsumatsu, Miaki Makiguchi, Makiko Shimizu, Hiroshi Yamazaki   +5 more
doaj   +1 more source

Food intake attenuates the drug interaction between new quinolones and aluminum

Journal of Pharmaceutical Health Care and Sciences, 2018
Background Intestinal absorption of new quinolones is decreased by oral administration of polyvalent metal cations. Some clinical studies have demonstrated this drug - drug interaction is more prominent under fasted condition. However, the effect of food
Ayuko Imaoka, Kosuke Abiru, Takeshi Akiyoshi, Hisakazu Ohtani   +3 more
doaj   +1 more source

Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health

Frontiers in Nutrition, 2022
Vitamin B consists of a group of water-soluble micronutrients that are mainly derived from the daily diet. They serve as cofactors, mediating multiple metabolic pathways in humans.
Zhijie Wan, Jianheng Zheng, Zhigang Zhu, Lan Sang, Jinwei Zhu, Shizheng Luo, Yixin Zhao, Ruirui Wang, Yicui Zhang, Kun Hao, Liang Chen, Jun Du, Juntao Kan, Hua He   +13 more
doaj   +1 more source

Population Pharmacokinetics and Pharmacodynamics of Extended-Infusion Piperacillin and Tazobactam in Critically Ill Children [PDF]

, 2015
The study objective was to evaluate the population pharmacokinetics and pharmacodynamics of extended-infusion piperacillintazobactam in children hospitalized in an intensive care unit.
Buenger, Lauren E., Chung, Eun Kyoung, Crumby, Ashley S., Dees, Jennifer, Healy, Daniel P., Kays, Michael B., Knoderer, Chad A., Nichols, Kristen R.   +7 more
core   +2 more sources