Results 91 to 100 of about 2,320,535 (398)

The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. [PDF]

, 2000
The pharmacology of hSK1, a small conductance calcium-activated potassium channel, was studied in mammalian cell lines (HEK293 and COS-7). In these cell types, hSK1 forms an apamin-sensitive channel with an IC(50) for apamin of 8 nM in HEK293 cells and ...
BENTON, CASTLE, DUNN, DUNN, HOSSEINI, ISHII, JURMAN, KHAWALED, KOHLER, LEWIS, SAH, VERGARA, WADSWORTH, WADSWORTH, YU   +14 more
core   +2 more sources

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

Nucleic Acids Res., 2015
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome.
C. Southan, J. Sharman, H. E. Benson, E. Faccenda, Adam J Pawson, Stephen P. H. Alexander, O. Buneman, A. Davenport, J. McGrath, J. A. Peters, M. Spedding, W. Catterall, D. Fabbro, J. Davies, Nc-Iuphar   +14 more
semanticscholar   +1 more source

Integration of Pharmacology into a Dental School’s Problem Based Learning Curriculum [PDF]

, 2010
poster abstractThe purpose of this study is to determine student perceptions of the methods used to teach pharmacology content via Problem Based Learning (PBL) cases with respect to student: comprehension application of pharmacology content, confidence ...
Garetto, L.P., Gregson, K.S., Romito, L.M.   +2 more
core  

Pharmacology of novel psychoactive substances [PDF]

, 2016
This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects.
Rickli, Anna
core   +1 more source

Members of the family Lamiaceae Lindl. as sources of medicinal plant raw materials to obtain neurotropic drugs

Фармация и фармакология (Пятигорск), 2020
The aim of this work is to review and analyze the data published in the modern scientific literature obtained in pharmacological, pharmacognostic and pharmacotechnological studies of various types of raw materials obtained from members of the family ...
Е. V. Zvezdina, J. V. Dayronas, I. I. Bochkareva, I. N. Zilfikarov, E. Yu. Babaeva, E. V. Ferubko, Z. A. Guseynova, F. K. Serebryanaya, S. R. Kaibova, T. A. Ibragimov   +9 more
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Pharmacology of Adenosine Receptors: The State of the Art.

Physiological Reviews, 2018
Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid generation of adenosine from cellular metabolism, and the widespread distribution
P. Borea, S. Gessi, S. Merighi, F. Vincenzi, K. Varani   +4 more
semanticscholar   +1 more source

Salivary biomarkers in psychobiological medicine. [PDF]

, 2006
The value of salivary biomarkers for diagnostic and prognostic assessments has become increasingly well established in medicine, pharmacology, and dentistry. Certain salivary components mirror the neuro-endocrine status of the organism.
Chiappelli, Francesco, Iribarren, Francisco Javier, Prolo, Paolo   +2 more
core   +2 more sources

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source