Results 101 to 110 of about 1,026,679 (318)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

The interplay between ferroptosis and inflammation: therapeutic implications for cerebral ischemia-reperfusion

Frontiers in Immunology
Stroke ranks as the second most significant contributor to mortality worldwide and is a major factor in disability. Ischemic strokes account for 71% of all stroke incidences globally.
Yuxuan He, Jingyi Wang, Chunmiao Ying, Kang Li Xu, Jingwen Luo, Baiqiao Wang, Jing Gao, Zaitian Yin, Yunke Zhang   +8 more
doaj   +1 more source

The effectiveness of pharmacological and lifestyle interventions to reduce the risk of diabetes and hyperglycaemia following gestational diabetes: A systematic review and meta‐analysis [PDF]

Rebecca A. Dennison, Clare Oliver‐Williams, Helen Lin Jia Qi, Deeya Kotecha, Lydia Seed, Rebecca Ward, Simon J. Griffin   +6 more
openalex   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Synthesis and pharmacological evaluation of N-substituted 4,6-diaryl-3-pyridazinones as Analgesic, antiinflammatory and antipyretic agents.

, 1989
Catherine Rubat, Pascal Coudert, Pierre Tronche, Jeanine BASTIDE, P Bastide, Anne-Marie Privat   +5 more
openalex   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Long-acting relaxin analogues: a novel tool in cardiology

Frontiers in Pharmacology
Serelaxin, a recombinant human relaxin, has emerged as a potential therapy for the future treatment of heart failure. However, its effectiveness has been limited by a short half-life and the need for intravenous administration.
Łukasz Wołowiec, Albert Jaśniak, Joanna Osiak-Gwiazdowska, Daria Czaplińska, Agata Szymczak, Julia Anna Pęcherz, Grzegorz Grześk   +6 more
doaj   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

New bearings in pharmacotherapeutic strategies: Pharmacogenetics and gene therapy [PDF]

Vojnosanitetski Pregled, 2007
Grbović Leposava, Radenković Miroslav, Đokić Jelena, Gojković-Bukarica Ljiljana, Dragović Gordana J.   +4 more
doaj   +1 more source

Celebrating milestones and embracing innovation: the next chapter for Drugs in Context

Drugs in Context
The Senior Editors of Drugs in Context are excited to announce that the journal received its first Impact Factor of 2.8 in the 2025 Edition of Journal Citation Reports1 by Clarivate. This represents a significant metric milestone, and the result of years
Sarah L Anderson, Arduino A Mangoni, Tiago Torres   +2 more
doaj   +1 more source