Results 101 to 110 of about 2,320,535 (398)

Applications of Network Pharmacology in Traditional Chinese Medicine Research

Evidence-Based Complementary and Alternative Medicine, 2020
Human diseases, especially infectious ones, have been evolving constantly. However, their treatment strategies are not developing quickly. Some diseases are caused by a variety of factors with very complex pathologies, and the use of a single drug cannot
Zhuchen Zhou, Bing Chen, Simiao Chen, Minqiu Lin, Ying Chen, Shan Jin, Weiyan Chen, Yuyan Zhang   +7 more
semanticscholar   +1 more source

Development perspectives of new generation medications based on the redox system regulators [PDF]

, 2016
This survey paper describes the necessity of the development of new medications influencing the body redox-potential. It supports the most pressing branch of pharmacology, which coincides with logically relevant attempts to shift paradigm of pharmacology
Galenko-Yaroshevsky, P. A., Gulevskaya, O. N., Kolesnichenko, P. D., Shahmardanova, S. A.   +3 more
core   +2 more sources

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

The Journal of pharmacy and pharmacology, 2019
Scutellaria baicalensis Georgi. (Lamiaceae) is a plant of the genus Lamiaceae, and its root is the main part used as a medicine. In China, Scutellaria baicalensis is still an important traditional Chinese medicine with the functions of clearing away heat
Tiantian Zhao, Hailong Tang, Long Xie, Yu Zheng, Zubing Ma, Qiang Sun, Xiaofang Li   +6 more
semanticscholar   +1 more source

A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research

British Journal of Pharmacology, 2020
Conclusions This editorial illustrates major requirements that authors should con- sider before submitting articles to BJP (see Table 3 for authors' check- list).
A. Izzo, Mauro M Teixeira, S. Alexander, G. Cirino, J. Docherty, Christopher H George, P. Insel, Yong Ji, D. Kendall, Reynold A. Panattieri, C. Sobey, S. Stanford, B. Stefańska, Gary J Stephens, A. Ahluwalia   +14 more
semanticscholar   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Studies of the physiology, pharmacology, and biochemistry of the auxins [PDF]

, 1952
Several excellent reviews of auxin matters have appeared during the past few years dealing broadly with the subject as a whole, such as the Wisconsin Symposium on Plant Growth Substances whleh is referred to repeatedly below, as well as reviews of more ...
Bandurski­, Robert S., Bonner, James
core   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Interaction between IP, TP, and 5-HT2 receptors during contractions to prostacyclin in rat renal arteries [PDF]

, 2015
Conference Theme: Tomorrow’s medicines: pharmacology, patients and populationspublished_or_final_versionConference Theme: Tomorrow's medicines: pharmacology, patients and ...
Baretella, OM, Vanhoutte, PMGR, Xu, A
core  

Critical appraisal and update on the clinical utility of agomelatine, a melatonergic agonist, for the treatment of major depressive disease in adults [PDF]

, 2009
This article describes the pharmacology of the novel atypical antidepressant drug agomelatine, critically reviews and evaluates its clinical use for the treatment of major depression, and suggests areas for further research.
Howland, RH
core   +1 more source