Results 71 to 80 of about 1,026,679 (318)

Adherence to Pharmacological Treatment and Factors Affecting the Adherence among Hypertensive Patients Attending Primary Health Care Centers in Jazan, Saudi Arabia

, 2021
Husameldin Elsawi Khalafalla, Ahmad A. Shugairi, Faisal A. Othathi, Abdulrahman Mohammed S. Alhuraysi, Abdulaziz Y. Albrraq, Ahmad Y. Rayani, Mohammed O. Shami, Mohammad A. Jareebi, Abrar A. Doweri   +8 more
openalex   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems

Frontiers in Pharmacology
Formononetin (FMN) is a common natural metabolite that can be extracted and isolated from some common botanical drugs. In recent years, FMN has garnered increasing attention due to its beneficial biological activities.
Min Jin, Linfang Wei, Jianhua Wang, Yuehong Shen, Lei Gao, Fan Zhao, Qianying Gao, Yifei Ma, Yongyan Sun, Ying Lin, Guanjie Ji, Pingping Cai, Rugen Yan   +12 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Neonatal Kidney Function, Injury and Drug Dosing: A Contemporary Review

Children
In neonates, estimation of the glomerular filtration rate is problematic, and assessment of renal impairment is challenging. Serum creatinine is a widely used marker, and urine output is an important vital parameter monitored in intensive care settings ...
Eveline Staub, Srinivas Bolisetty, Karel Allegaert, Anke Raaijmakers   +3 more
doaj   +1 more source

Effects of non-supervised low intensity aerobic excise training on the microvascular endothelial function of patients with type 1 diabetes: a non-pharmacological interventional study [PDF]

, 2016
Roger de Moraes, Diogo Van Bavel, Marília Brito Gomes, Eduardo Tibiriçá   +3 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Alantolactone Inhibits Double Expression Lymphoma via Dual-Targeted Glycogen Synthase Kinase 3 Beta and B-Cell Lymphoma2

Blood and Lymphatic Cancer: Targets and Therapy
Jianhua Chen,1,* Qing Liao,1,2,* Sha Yang,1 Jiaojiao Bian,1 Xianfu Li,3 Lu Zhao,4 Dan Wen,1 Dazhang Bai,5 Chunlei Yu,1 Chunyang Zhou,1 Zhengmin Xu1,6 1Department of Pharmacology Institute of Materia Medica, School of Pharmacy, North ...
Chen J, Liao Q, Yang S, Bian J, Li X, Zhao L, Wen D, Bai D, Yu C, Zhou C, Xu Z   +10 more
doaj  

The veterinary medicinal products market supply gap: A practical insight based on the Regulation (EU) 2019/6

Revista de Ciências Agroveterinárias
The Regulation (EU) 2019/6 establishes that the veterinary prescriptions should follow a cascade, according to their availability of the market. In sum, the veterinarian is authorized to use a medicine for human use only if there is no product available
Rafaela Nogueira, Catarina Jota Baptista, Lio Gonçalves, Ana Claúdia Coelho, Ana I. Faustino-Rocha, Marta Regueiro Purriños, José M. Gonzalo-Orden, Paula A. Oliveira   +7 more
doaj   +1 more source

iECA: physiology behind veterinary pharmacology

, 2023
Natália Gageiro Pinto Russo
openalex   +2 more sources