Results 71 to 80 of about 1,582,171 (351)
Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation [PDF]
, 2018 During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the sources of
Bailey +40 more
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Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Effectiveness of team based learning to teach pharmacology for phase-II MBBS students [PDF]
Al Ameen Journal of Medical Sciences, 2014 Background: TBL (Team based Learning) instructional methods foster applying knowledge in a highly interactive setting. Furthermore, in contrast to PBL (Problem Based Learning), it is a teacher directed method that encourages student- student interaction.
N.K. Hashilkar, M.H. Gelula
doaj
How Can Network-Pharmacology Contribute to Antiepileptic Drug Development? [PDF]
, 2014 Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of exquisitely selective drugs. What is
Di Ianni, Mauricio Emiliano +1 more
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, 2004 Dermatology continues to develop at a steady pace. In the past few years there have been exciting advances in our understanding of skin structure and function in health and disease and progress in genetics, epidemiology, immunology, pharmacology and ...
Boffa, Michael J.
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Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Pharmacological Methods of Pain Management: Narrative Review of Medication Used
International Journal of General Medicine, 2023 Nasser M Alorfi Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi ArabiaCorrespondence: Nasser M Alorfi, Email Nmorfi@uqu.edu.saBackground: Pain management is a critical aspect of healthcare, aimed at ...
Alorfi NM
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TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Assessment and management of pain in older adults with dementia : a review of current practice and future directions [PDF]
, 2008 Pain in older adults has received increasing attention within the literature during the last decade, and in the past 12 months, there have been a number of papers published that highlight several key issues in the area.
Schofield, Pat
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Reumatismo, 2014 This article discusses the mechanisms of action of the main drugs used to treat pain, in particular inflammatory pain. The drugs are described following a classification based on the steps of pain processing that they primarily affect.
Fornasari D., COACCIOLI, Stefano
openaire +7 more sources