Pharmacometrics in the Age of Large Language Models: A Vision of the Future [PDF]
PharmaceuticsBackground: Large Language Models (LLMs) have driven significant advances in artificial intelligence (AI), with transformative applications across numerous scientific fields, including biomedical research and drug development.
Elena Maria Tosca +3 more
doaj +2 more sources
AI for NONMEM Coding in Pharmacometrics Research and Education: Shortcut or Pitfall? [PDF]
CPT: Pharmacometrics & Systems PharmacologyArtificial intelligence (AI) is increasingly being explored as a tool to support pharmacometric modeling, particularly in addressing the coding challenges associated with NONMEM.
Wenhao Zheng +5 more
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Tutorial on Causal Mediation Analysis for Pharmacometricians [PDF]
CPT: Pharmacometrics & Systems PharmacologyMediation analyses can support biomarker development by quantifying the part of the total treatment effect on clinical outcome that is mediated by the biomarker.
Sebastiaan Camiel Goulooze +2 more
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Assessment and Benchmarking of Model Informed Approaches in Drug Development for Hemoglobinopathies: A Review of Scientific Advices From January 2000 to December 2024 [PDF]
CPT: Pharmacometrics & Systems PharmacologyDespite the fact that modeling and simulation are now recognized as promising innovative methodologies, their use in the context of development of drugs for sickle cell disease and Thalassemia has not yet been reviewed.
Grace Shalom Govere +2 more
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Integrating Population Approaches With Physiologically Based Pharmacokinetic Models: A Novel Framework for Parameter Estimation [PDF]
CPT: Pharmacometrics & Systems PharmacologyPhysiologically Based Pharmacokinetic (PBPK) modeling is a powerful tool in drug development that integrates drug‐specific information with physiological parameters to predict drug concentrations.
Donato Teutonico +3 more
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The Basel Modeling and Simulation Seminar: 20 Editions of Fostering Local Exchange in Pharmacometrics [PDF]
CPT: Pharmacometrics & Systems PharmacologyThis year marks the 20th edition of the Basel Modeling and Simulation (M&S) Seminar, an initiative rooted in a commitment to promoting the exchange of the latest advancements in pharmacometrics and related disciplines in the region of Basel, Switzerland.
Tamara vanDonge +6 more
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Population Pharmacokinetic/Pharmacodynamic Modeling of Donidalorsen, an Antisense Oligonucleotide in Development for Prophylaxis of Hereditary Angioedema [PDF]
CPT: Pharmacometrics & Systems PharmacologyHereditary angioedema (HAE) is a rare disorder linked to kallikrein‐kinin system dysregulation, which leads to uncontrolled activation of plasma prekallikrein.
John K. Diep +7 more
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Concept and utility of population pharmacokinetic and pharmacokinetic/pharmacodynamic models in drug development and clinical practice [PDF]
Arhiv za farmaciju, 2021 Due to frequent clinical trial failures and consequently fewer new drug approvals, the need for improvement in drug development has, to a certain extent, been met using model-based drug development.
Roganović Maša +6 more
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CPT: Pharmacometrics & Systems Pharmacology, 2021 Pharmacometrics is an emerging science that interprets drug, disease, and trial information in a mathematical fashion to inform and facilitate efficient drug development and/or regulatory decisions.
Ming Zhao +9 more
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Pharmaceutics, 2022 Pharmacometrics is a multidisciplinary field utilizing mathematical models of physiology, pharmacology, and disease to describe and quantify the interactions between medication and patient.
Alexander Janssen +2 more
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