Results 151 to 160 of about 6,010 (176)
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Pharmacometrics in Pregnancy: An Unmet Need
Annual Review of Pharmacology and Toxicology, 2014Pregnant women and their fetuses are orphan populations with respect to the safety and efficacy of drugs. Physiological and absorption, distribution, metabolism, and excretion (ADME) changes during pregnancy can significantly affect drug pharmacokinetics (PK) and may necessitate dose adjustment.
Ke, Alice Ban +3 more
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Pharmacometrics of Hyperlipidemia
2014Arteriosclerosis of the coronary and peripheral vasculature is the undisputed leading cause of death worldwide resulting from cardiovascular disease, peripheral vascular disease, and stroke. Lipoproteins represent a surrogate for one of the significant cardiovascular risk factors, and mathematical models to understand lipoprotein kinetics have been ...
Maurice G. Emery +2 more
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Pharmacometrics of Viral Infections
2014Antiviral drugs play a crucial role in the treatment of human infections caused by viral pathogens. In order for antiviral therapy to be efficacious, the optimal dose and dosing interval for each compound must be identified. Optimal dosage regimens are defined as regimens that maximize inhibition of viral replication, prevent the emergence of ...
George L. Drusano, Ashley N. Brown
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Pharmacometrics in Cardiovascular Safety
2014Approximately one third of all drug discontinuation from preclinical discovery to postapproval stage is caused by drug safety, with a large contribution of cardiovascular (CV) safety findings. Moreover, drug-induced QT prolongation and proarrhythmic liabilities have been the main reasons for labeling restrictions and drug withdrawals after approval ...
Joanna Parkinson +3 more
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Pharmacometrics in Pulmonary Diseases
2014Inhalation therapy has been successfully applied to treat respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD) with the primary goal of lung targeting, i.e., maximizing the beneficial local effects while keeping the systemic side effects to a minimum.
Bhargava Kandala, Günther Hochhaus
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2014
Pharmacometric approaches applied to the design and analysis of pediatric clinical pharmacology trials are essential for providing informative dosing guidance in children. This chapter reviews the key questions that define the proper implementation of pharmacometrics in the study of pediatric populations, examines historical, current, and optimal ...
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Pharmacometric approaches applied to the design and analysis of pediatric clinical pharmacology trials are essential for providing informative dosing guidance in children. This chapter reviews the key questions that define the proper implementation of pharmacometrics in the study of pediatric populations, examines historical, current, and optimal ...
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Evaluation of Assumptions Underpinning Pharmacometric Models
The AAPS Journal, 2019Assumptions inherent to pharmacometric model development and use are not routinely acknowledged, described, or evaluated. The aim of this work is to present a framework for systematic evaluation of assumptions. To aid identification of assumptions, we categorise assumptions into two types: implicit and explicit assumptions.
Qing-Xi Ooi +3 more
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Pharmacometrics and Tuberculosis
2014There are very few effective tuberculosis (TB) drugs available, and for active disease, they must be used in combinations of four or more drugs and for many months. Treatment guidelines are very helpful, and include considerable empiric evidence.
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Pharmacometrics in Bacterial Infections
2014Pharmacometrics plays an important role in rational dosing design of antimicrobial therapy by defining the relationship between dose, dosing interval, drug concentration, bacterial response, infection outcome, and toxicity, as well as the variability surrounding these variables.
Sherwin K. B. Sy, Hartmut Derendorf
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Pharmacometrics in Psychiatric Diseases
2014Psychiatric disorders may have a huge impact on someone’s personal functioning as well as on the person’s interaction with others. Treatment with psychoactive drugs may be helpful, but there is much room for improvement. To this end, we need much more insight into the disease processes, the fate of psychoactive drugs in the body (particularly the brain)
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