Results 11 to 20 of about 6,010 (176)
Metaheuristics for pharmacometrics [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2021 Metaheuristics is a powerful optimization tool that is increasingly used across disciplines to tackle general purpose optimization problems. Nature‐inspired metaheuristic algorithms is a subclass of metaheuristic algorithms and have been shown to be ...
Seongho Kim +4 more
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CPT: Pharmacometrics & Systems PharmacologyWe present here a repository of key regulatory questions answered in centralized procedures and evaluate the place of modeling and simulation in marketing authorization process for biologics approved for the treatment of moderate‐to‐severe asthma from ...
Hélène Haguet +2 more
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Advances in Pharmacological and Pharmaceutical Sciences, 2023 Pharmacotherapy, in many cases, is practiced at a suboptimal level of performance in low- and middle-income countries (LMICs) although stupendous amounts of data are available regularly.
Muhammad Usman +5 more
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Pharmacometrics approaches and its applications in diabetes: An overview
Journal of Pharmacy and Bioallied Sciences, 2021 Type 2 diabetes mellitus is the most prevalent and progressive in nature. As the time progress, the multifaceted complications and comorbidities associated to diabetes worsen in the form of macrovascular or microvascular or both. Pharmacometrics modeling
Sohail Aziz +3 more
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Variable or variate? A conundrum in pharmacometrics exposure–response models
CPT: Pharmacometrics & Systems Pharmacology, 2023 Key elements of scientific writing—consistency and clarity—can be compromised in case of inaccurate use of methodological terms, especially in complex and multidisciplinary scientific fields.
Ana‐Marija Grisic +3 more
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Pharmacometrics in tuberculosis: progress and opportunities [PDF]
International Journal of Antimicrobial Agents, 2022 Tuberculosis (TB) remains one of the leading causes of death by a communicable agent, infecting up to one-quarter of the world's population, predominantly in disadvantaged communities. Pharmacometrics employ quantitative mathematical models to describe the relationships between pharmacokinetics and pharmacodynamics, and to predict drug doses, exposures
Wilkins, J.J. +6 more
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CPT: Pharmacometrics & Systems Pharmacology, 2021 Pediatric extrapolation is essential for bringing treatments to the pediatric population, especially for indications where the recruitment of pediatric patients into clinical trials is difficult and where fully powered trials are impossible.
Thomas Dumortier +2 more
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CPT: Pharmacometrics & Systems Pharmacology, 2021 The success of applications of physiologically‐based pharmacokinetic (PBPK) modeling in drug development and drug labeling has triggered regulatory agencies to demand rigorous demonstration of the predictive capability of the specific PBPK platform for a
Sebastian Frechen +7 more
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Pharmacometric Characterization of Dabigatran Hemodialysis [PDF]
Clinical Pharmacokinetics, 2013 Hemodialysis has been shown to be a useful method of decreasing dabigatran plasma levels in situations that require rapid elimination of this thrombin inhibitor. However, there is currently no clinical recommendation for the accelerated/optimized elimination of dabigatran via hemodialysis (e.g., flow rates, filter type, duration of dialysis).The ...
Liesenfeld, Karl-Heinz +5 more
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Frontiers in Pharmacology, 2020 Physiologically based pharmacokinetic (PBPK) models are increasingly used to support pediatric dose selection for small molecule drugs. In contrast, only a few pediatric PBPK models for therapeutic antibodies have been published recently, and the ...
Sumit Basu +6 more
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