Results 51 to 60 of about 88,845 (204)

Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7‐Polarized Microfilament Coordination in Breast Cancer Cells

Advanced Science, EarlyView.
This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu, Zihui Zheng, Wang Li, Chenyi Shou, Ying Zhao, Lijun Zhang, Xiaoli Shi, Yunfeng Hu, Huanhuan Zhao, Huiwen Wu, Jun Guo   +10 more
wiley   +1 more source

Danshen-Shanzha formula for the treatment of atherosclerosis: ethnopharmacological relevance, preparation methods, chemical constituents, pharmacokinetic properties, and pharmacological effects

Frontiers in Pharmacology
Danshen-Shanzha Formula (DSF) is a well-known herbal combination comprising Radix Salvia Miltiorrhiza (known as Danshen in Chinese) and Fructus Crataegi (known as Shanzha in Chinese), It has been documented to exhibit considerable benefits for promoting ...
Qiong Xu, Zhe Yu, Meng Zhang, Meng Zhang, Tian Feng, Fan Song, Haifeng Tang, Siwang Wang, Hua Li   +8 more
doaj   +1 more source

Clinical Pharmacology in the UK, c.1950-2000: Influences and Institutions [PDF]

, 2008
Annotated and edited transcript of a Witness Seminar held on 6 February 2007. Introduction by Dr Mark Walport, The Wellcome Trust.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2008.©The Trustee of the Wellcome Trust ...
Reynolds, LA, Tansey, EM
core  

A Programmable Nanoreactor Orchestrates Cascade of DNA Sensing to Amplify cGAS‐STING Activation for Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable nanoreactor was engineered for precise cGAS‐STING pathway activation in cancer immunotherapy. This strategy bridges targeted tumor DNA damage with DC immunomodulation, providing a translatable platform to unlock innate and adaptive antitumor immunity.
Shuang Liang, Yiwei Tian, Feiyu Zhao, Yue Han, Kongshuo Ma, Linna Hai, Kaiqing Yun, Yueyang Zhao, Siqi Zhang, Ziyi Zhang, Yuxuan Peng, Kuan Hu, Jing Zhong, Bai Xiang, Zhaohui Wang   +14 more
wiley   +1 more source

The Jefferson Medical College of Philadelphia: From 1825 to 1908 [PDF]

, 1908
This brief 1908 history of Jefferson Medical College was written by James W. Holland. An 1868 graduate, Holland went on to become the Dean of Jefferson Medical College in 1887https://jdc.jefferson.edu/jeffersonhistorybooks/1007/thumbnail ...
Holland, James W.
core   +1 more source

Comparison of veterinary drugs and veterinary homeopathy: part 1 [PDF]

, 2017
For many years after its invention around 1796, homeopathy was widely used in people and later in animals. Over the intervening period (1796-2016) pharmacology emerged as a science from Materia Medica (medicinal materials) to become the mainstay of ...
AABEL, AHN, ANICK, BEKELMAN, BELL, BELL, BELL, BELLAVITE, BELON, BELON, BOERICKE, CALABRESE, CALABRESE, CALABRESE, CALABRESE, CAMPBELL, CANFIELD, CARTWRIGHT, CHAMBERS, CHAMBERS, CHAN, CHAPMAN, CHIKRAMANE, CONZEMIUS, COWAN, CROSKERRY, CROSKERRY, CUCHERAT, CUNNINGHAM, DAVENAS, DI GIROLAMO, DOEHRING, DOUST, EASTERBROOK, ELIA, ENNIS, ERNST, FLOWER, FRASER, GARTLEHNER, GAY, GODWIN, GOLDACRE, GREGORY, GREGORY, GREGORY, GRIMES, GRUEN, GRUEN, HAHNEMANN, HARTMAN, HEKTOEN, HEKTOEN, HIRST, HOVI, HRÓBJARTSSON, IOANNIDIS, IOANNIDIS, IOANNIDIS, IOANNIDIS, IOANNIDIS, JACOBS, JADAD, JONAS, JONAS, KAHANB, KAHNEMAN, KAYNE, KAYNE, KOHN, LEE, LEES, LEES, LEES, LEXCHIN, LILLEY, LINDE, MADDOX, MATHIE, MATHIE, MATHIE, MATHIE, MATHIE, MATHIE, MATHIE, MATHIE, MATUTE, MCGAURAN, MCKENZIE, MILAZZO, MILGROM, MONTAGNIER, NICOLAI, OWEN, OWEN, OWEN, OWEN, OXTOBY, PAULSON, PINTO, PRASAD, RAO, REILLY, REY, REY, RILEY, ROY, RUDOLF, SACKETT, SAPOSNIK, SARGEANT, SARGEANT, SCHULZ, SHANG, SHAW, SHERR, SHOJANIA, SMITH, SMITH, STERN, TEMGIRE, TOUTAIN, VAN WIJK, VANDENBERG, VIERA, WHITEHEAD, WHITING, WORLD HEALTH, ZOONOSES AND PUBLIC   +128 more
core   +5 more sources

Biomimetic Iridium‐Based Photothermal Nanozyme to Trigger Ferroptosis and Pyroptosis and Activate the cGAS‐STING Pathway for Improved Tumor Immunotherapy

Advanced Science, EarlyView.
This study develops an iridium‐based nanozyme (IIN@M) with superior enzyme‐like activity and photothermal performance. It disrupts intracellular redox balance by generating reactive oxygen species and depleting glutathione, which synergistically induces ferroptosis, pyroptosis, and immunogenic cell death.
Lijun Ding, Zhongxiong Fan, Guoyu Xia, Fukai Zhu, Nan Yang, Shujie Yu, Longlong Yuan, Jinyao Li   +7 more
wiley   +1 more source

Effective extraction of Xuetongsu and its role in preventing RA synovial hyperplasia by targeting synovial cell migration and apoptosis

Scientific Reports
Kadsura heteroclita (Roxb) Craib also named Xuetong in Tujia ethnomedicine in China, has been traditionally employed in rheumatoid arthritis (RA) treatment.
Yasi Deng, Hao Zheng, Shiqi Liu, Ying Deng, Yuxin Chen, Ling Liang, Mengyun Wang, Qingling Xie, Yupei Yang, Bin Li, Juan Huang, Hanwen Yuan, Huanghe Yu, Wei Wang   +13 more
doaj   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Cryptotanshinone inhibits PFK-mediated aerobic glycolysis by activating AMPK pathway leading to blockade of cutaneous melanoma

Chinese Medicine
Background Cutaneous melanoma is a kind of skin malignancy with low morbidity but high mortality. Cryptotanshinone (CPT), an important component of salvia miltiorrhiza has potent anti-tumor activity and also indicates therapeutic effect on dermatosis. So
Qiong Chen, Yang Liu, Yunxuan Zhu, Ziyan Zhu, Jueyao Zou, Yanhong Pan, Yin Lu, Wenxing Chen   +7 more
doaj   +1 more source