Results 51 to 60 of about 2,739,138 (153)

Cancer Immunotherapy Based on the Bidirectional Reprogramming of the Tumor Microenvironment by a “Brakes Off/ Step on the Accelerator” Core‐Shell Manganese Phosphate/siPD‐L1 Modulator

Exploration, EarlyView.
To enhance the comprehensive treatment effect of triple‐negative breast cancer, a pH‐responsive core‐shell manganese phosphate nano‐regulator was prepared to reprogram the tumor microenvironment bi‐directionally. (1) “Brakes off”: Using siPD‐L1 to inhibit PD‐L1 expression to restore CD8+ T cell function.
Fei Xia, Yuqian Lu, Zipeng Gong, Qingchao Tu, Shuntao Liang, Chen Wang, HaiLu Yao, LinYing Zhong, Yuanfeng Fu, Pengbo Guo, Yichong Hou, Xinyu Zhou, Li Zou, Licheng Gan, Weiqi Chen, Jiawei Yan, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Chen Pan, Xiaomei Tao, Jigang Wang, Qingfeng Du, Chong Qiu   +24 more
wiley   +1 more source

Astragaloside IV accelerates hematopoietic reconstruction by improving the AMPK/PGC1α-mediated mitochondrial function in hematopoietic stem cells

Chinese Medicine
Background Radiotherapy can damage hematopoietic stem cells (HSC) in bone marrow, leading to impaired hematopoietic function. Current treatments mainly target differentiated hematopoietic progenitor cells, which may accelerate their depletion ...
Ling Zhang, Wanqi Xu, Yueying Zeng, Long Wang, Jiesi Luo, Xiaogang Zhou, Qibing Mei, Dalian Qin, Anguo Wu, Jianming Wu, Feihong Huang   +10 more
doaj   +1 more source

Review Article: Integral Role of Physics in Advancing Pharmacy Education and Research [PDF]

EMUJPharmSci Volume: 7 Issue: 3 Pages: 122-132 (2024)
Physics plays a fundamental role in advancing pharmacy education and research, providing theoretical underpinnings and practical tools necessary to address complex challenges in drug development, delivery, and diagnostics. This review explores the integration of physics into the pharmacy curriculum, highlighting how principles such as fluid dynamics ...
arxiv   +1 more source

Limitations in Predicting Radiation-Induced Pharmaceutical Instability during Long-Duration Spaceflight [PDF]

Nature Microgravity 5:15 (2019), 2019
As human spaceflight seeks to expand beyond low-Earth orbit, NASA and its international partners face numerous challenges related to ensuring the safety of their astronauts, including the need to provide a safe and effective pharmacy for long-duration spaceflight.
arxiv   +1 more source

Traditional Chinese Medicine Properties and Microcalorimetry: BioScience Evaluation

Med Research, EarlyView.
ABSTRACT The properties theory of traditional Chinese medicine (TCM), characterized by cold, hot, warm, and cool four properties, is fundamental to its development, distinguishing it from natural, botanical, and chemical medicines. However, despite its significance, there is no unified theoretical definition, bioscientific characterization, or ...
Qiang Li, Hengrui Liu, Jiayan Jin, Yixin Zhang, Shuyi Li, Lin Wang, Shirong Zhao, Chutse Wu, Zhie Fang, Jide Jin   +9 more
wiley   +1 more source

Resveratrol ameliorates atherosclerosis induced by high-fat diet and LPS in ApoE−/− mice and inhibits the activation of CD4+ T cells

Nutrition & Metabolism, 2020
Background Atherosclerosis (AS), which characterized with the accumulation of lipids on the vessel wall, is the pathological basis of many cardiovascular diseases (CVD) and seriously threatens human health.
Liyu Zhou, Jun Long, Yuting Sun, Weikai Chen, Runze Qiu, Dongping Yuan   +5 more
doaj   +1 more source

Overnutrition-induced gout: An immune response to NLRP3 inflammasome dysregulation by XOD activity increased in quail

Frontiers in Immunology, 2022
BackgroundGout is a progressive metabolic disease closely related to hyperuricemia and urate deposition, with an increasing prevalence and incidence across the globe.
Hao Wu, Yu Wang, Zhixin Ren, Yaolei Li, Jingjian Huang, Zhijian Lin, Zhijian Lin, Bing Zhang, Bing Zhang   +8 more
doaj   +1 more source

Equity Impacts of Dollar Store Vaccine Distribution [PDF]

arXiv, 2021
We use geospatial data to examine the unprecedented national program currentlyunderway in the United States to distribute and administer vaccines against COVID-19. We quantify the impact of the proposed federal partnership with the companyDollar General to serve as vaccination sites and compare vaccine access with DollarGeneral to the current Federal ...
arxiv  

Understanding of endo/lysosomal escape of nanomaterials in biomedical application

Smart Molecules, EarlyView.
This review summarized mainstream mechanisms of endo/lysosomal escape and design strategies of endo/lysosomal escapable nanoparticles in view of surface charge, polarity & hydrophobicity, particle morphology, and lysosomal escape agents. The utilization of endo/lysosomal escapable nanoparticles for vaccine delivery and genetic engineering are ...
Xin Wang, Haoyu Li, Chen Chen, Zhihui Liang   +3 more
wiley   +1 more source

Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets

Molecular Medicine
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by inflammation of the synovial tissue and joint bone destruction, often leading to significant disability.
Hao Zheng, Yuexuan Liu, Yasi Deng, Yunzhe Li, Shiqi Liu, Yong Yang, Yun Qiu, Bin Li, Wenbing Sheng, Jinzhi Liu, Caiyun Peng, Wei Wang, Huanghe Yu   +12 more
doaj   +1 more source