Results 81 to 90 of about 2,719,120 (253)

Cancer Immunotherapy Based on the Bidirectional Reprogramming of the Tumor Microenvironment by a “Brakes Off/ Step on the Accelerator” Core‐Shell Manganese Phosphate/siPD‐L1 Modulator

Exploration, EarlyView.
To enhance the comprehensive treatment effect of triple‐negative breast cancer, a pH‐responsive core‐shell manganese phosphate nano‐regulator was prepared to reprogram the tumor microenvironment bi‐directionally. (1) “Brakes off”: Using siPD‐L1 to inhibit PD‐L1 expression to restore CD8+ T cell function.
Fei Xia, Yuqian Lu, Zipeng Gong, Qingchao Tu, Shuntao Liang, Chen Wang, HaiLu Yao, LinYing Zhong, Yuanfeng Fu, Pengbo Guo, Yichong Hou, Xinyu Zhou, Li Zou, Licheng Gan, Weiqi Chen, Jiawei Yan, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Chen Pan, Xiaomei Tao, Jigang Wang, Qingfeng Du, Chong Qiu   +24 more
wiley   +1 more source

Correction: A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis [PDF]

Cell Death and Disease
Jie Zheng, Lu Yao, Yijing Zhou, Xiaoqun Gu, Can Wang, Kaifan Bao, Yang Sun, Min Hong   +7 more
doaj   +2 more sources

Resveratrol ameliorates atherosclerosis induced by high-fat diet and LPS in ApoE−/− mice and inhibits the activation of CD4+ T cells

Nutrition & Metabolism, 2020
Background Atherosclerosis (AS), which characterized with the accumulation of lipids on the vessel wall, is the pathological basis of many cardiovascular diseases (CVD) and seriously threatens human health.
Liyu Zhou, Jun Long, Yuting Sun, Weikai Chen, Runze Qiu, Dongping Yuan   +5 more
doaj   +1 more source

Overnutrition-induced gout: An immune response to NLRP3 inflammasome dysregulation by XOD activity increased in quail

Frontiers in Immunology, 2022
BackgroundGout is a progressive metabolic disease closely related to hyperuricemia and urate deposition, with an increasing prevalence and incidence across the globe.
Hao Wu, Yu Wang, Zhixin Ren, Yaolei Li, Jingjian Huang, Zhijian Lin, Zhijian Lin, Bing Zhang, Bing Zhang   +8 more
doaj   +1 more source

Equity Impacts of Dollar Store Vaccine Distribution [PDF]

arXiv, 2021
We use geospatial data to examine the unprecedented national program currentlyunderway in the United States to distribute and administer vaccines against COVID-19. We quantify the impact of the proposed federal partnership with the companyDollar General to serve as vaccination sites and compare vaccine access with DollarGeneral to the current Federal ...
arxiv  

Old School Catalog 1912-13, Chicago College of Medicine and Surgery [PDF]

, 1912
https://scholar.valpo.edu/oldschoolcatalogs/1010/thumbnail ...
Valparaiso University
core   +1 more source

Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets

Molecular Medicine
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by inflammation of the synovial tissue and joint bone destruction, often leading to significant disability.
Hao Zheng, Yuexuan Liu, Yasi Deng, Yunzhe Li, Shiqi Liu, Yong Yang, Yun Qiu, Bin Li, Wenbing Sheng, Jinzhi Liu, Caiyun Peng, Wei Wang, Huanghe Yu   +12 more
doaj   +1 more source

Danshen-Shanzha formula for the treatment of atherosclerosis: ethnopharmacological relevance, preparation methods, chemical constituents, pharmacokinetic properties, and pharmacological effects

Frontiers in Pharmacology
Danshen-Shanzha Formula (DSF) is a well-known herbal combination comprising Radix Salvia Miltiorrhiza (known as Danshen in Chinese) and Fructus Crataegi (known as Shanzha in Chinese), It has been documented to exhibit considerable benefits for promoting ...
Qiong Xu, Zhe Yu, Meng Zhang, Meng Zhang, Tian Feng, Fan Song, Haifeng Tang, Siwang Wang, Hua Li   +8 more
doaj   +1 more source

Datamining a medieval medical text reveals patterns in ingredient choice that reflect biological activity against the causative agents of specified infections [PDF]

arXiv, 2018
The pharmacopeia used by physicians and lay people in medieval Europe has largely been dismissed as placebo or superstition. While we now recognise that some of the materia medica used by medieval physicians could have had useful biological properties, research in this area is limited by the labour-intensive process of searching and interpreting ...
arxiv  

Evaluating Link-Based Techniques for Detecting Fake Pharmacy Websites [PDF]

arXiv, 2013
Fake online pharmacies have become increasingly pervasive, constituting over 90% of online pharmacy websites. There is a need for fake website detection techniques capable of identifying fake online pharmacy websites with a high degree of accuracy. In this study, we compared several well-known link-based detection techniques on a large-scale test bed ...
arxiv