Results 81 to 90 of about 84,518 (238)

Cryptotanshinone inhibits PFK-mediated aerobic glycolysis by activating AMPK pathway leading to blockade of cutaneous melanoma

open access: yesChinese Medicine
Background Cutaneous melanoma is a kind of skin malignancy with low morbidity but high mortality. Cryptotanshinone (CPT), an important component of salvia miltiorrhiza has potent anti-tumor activity and also indicates therapeutic effect on dermatosis. So
Qiong Chen   +7 more
doaj   +1 more source

Single‐cell sequencing and mass spectrometry imaging reveal the multicellular compartmentalization map of plant triterpenes: A ginsenoside in Panax ginseng example

open access: yesPlant Biotechnology Journal, EarlyView.
Summary Revealing the multicellular compartmentalization map is crucial for plant breeding and metabolism regulation. Despite the importance of triterpenes as active compounds, there has been no report on their biosynthetic multicellular mapping. In this study, ginsenosides are used as an example to reveal the multicellular compartmentalization map of ...
Rubing Wang   +8 more
wiley   +1 more source

The Jefferson Medical College of Philadelphia: From 1825 to 1908 [PDF]

open access: yes, 1908
This brief 1908 history of Jefferson Medical College was written by James W. Holland. An 1868 graduate, Holland went on to become the Dean of Jefferson Medical College in 1887https://jdc.jefferson.edu/jeffersonhistorybooks/1007/thumbnail ...
Holland, James W.
core   +1 more source

Unveiling the catalytical roles of three glycosyltransferases in triterpenoid saponins in quinoa

open access: yesPlant Biotechnology Journal, EarlyView.
Summary Saponins constitute a class of characteristic compounds within quinoa grains. In this study, metabolomic analysis identified 20 triterpene saponins, the majority of which were exclusively localized within the pericarp. Furthermore, three crucial glycosyltransferases were identified in quinoa.
Yiming Zhang   +14 more
wiley   +1 more source

Artemisinins in autoimmune diseases: effects and mechanisms in systemic lupus erythematosus and rheumatoid arthritis

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 15, Page 3411-3427, August 2025.
Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) result from immune self‐tolerance loss, causing tissue damage. Standard treatments targeting late‐stage inflammation often have serious side effects. Artemisinin, known for its antimalarial properties, shows potential immunomodulatory effects.
Fanchao Zhou   +4 more
wiley   +1 more source

The First 125 Years : 1838-1963 [PDF]

open access: yes, 1963
The Medical College of Virginia (MCV) marked the 125th anniversary of its founding with a year-long celebration in 1963, culminating in the publication of The First 125 Years. Issued as hard- and soft-back publications in the college\u27s bulletin series,

core   +1 more source

Connexin43 Promotes the Invasion and Metastasis of Lung Squamous Cell Carcinoma via GJIC‐Dependent Ca2+/ERK Signaling Activation

open access: yesCancer Science, Volume 116, Issue 8, Page 2086-2100, August 2025.
Cx43 mediated GJIC‐dependent delivery of second messenger Ca2+ thus activating the ERK signaling pathway. Verapamil, effective effectively inhibits these pathways. ABSTRACT Lung squamous cell carcinoma (LUSC) is an extremely metastatic cancer with limited available treatment and poor outcomes.
Xiaocheng Mo   +14 more
wiley   +1 more source

Maltese medical Pauline traditions [PDF]

open access: yes, 2010
The advent of the apostle Paul and evangelist Luke to the Maltese Islands in 60 AD led to the development of a number of pseudo-historic and medical beliefs that apparently saw their rise around the 12th century and reached a climax during the 17-18th ...
Savona-Ventura, Charles
core  

Inhibition Effects of Patchouli Alcohol, Carvacrol, p‐Cymene, Eucalyptol and Their Formulations Against Influenza Virus Pneumonia Through TLR4/NF‐κB/NLRP3 Signaling Pathway

open access: yesChemical Biology &Drug Design, Volume 106, Issue 2, August 2025.
The study provides an experimental basis for volatile monomers of aromatic herbs to be formulated for the treatment of influenza virus pneumonia. The overall scope of the study is shown in the image. ABSTRACT As a kind of drug mostly used historically to treat epidemics, aromatic botanicals have volatile oils as active components.
Ruilin Lv   +9 more
wiley   +1 more source

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