Results 81 to 90 of about 88,845 (204)

Making the Old New Again Through the Process of Recombinant Innovation

Journal of Product Innovation Management, Volume 43, Issue 2, Page 290-312, March 2026.
ABSTRACT Academic Summary Recombinant innovation—the process through which atypical and unexpected combinations of knowledge generate novel outcomes—is a critical driver of organizational distinctiveness and market transformation. While prior research has focused on firm‐ and industry‐level mechanisms, less attention has been given to multilevel ...
Vittoria Magrelli, Josip Kotlar, Alfredo De Massis, Federico Frattini, Antonio Messeni Petruzzelli   +4 more
wiley   +1 more source

The First 125 Years : 1838-1963 [PDF]

, 1963
The Medical College of Virginia (MCV) marked the 125th anniversary of its founding with a year-long celebration in 1963, culminating in the publication of The First 125 Years. Issued as hard- and soft-back publications in the college\u27s bulletin series,

core   +1 more source

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study introduces a biomimetic nanoplatform (MTCA@C) designed for precise cancer therapy. It targets mitochondria to induce dysfunction through photodynamic activation, while concurrently blocking mitophagy via lysosomal alkalinization. The platform further triggers methuosis, resulting in tumor cell death through vacuolization and energy pathway ...
Xiao Xu, Qiqing Huang, Yang Liu, Jinzhuo Liu, Deyi Yang, Yanni Song, Xin Han   +6 more
wiley   +1 more source

Identification of Candidate Biomarkers Correlated With the Pathogenesis and Prognosis of Non-small Cell Lung Cancer via Integrated Bioinformatics Analysis

Frontiers in Genetics, 2018
Background and Objective: Non-small cell lung cancer (NSCLC) accounts for 80–85% of all patients with lung cancer and 5-year relative overall survival (OS) rate is less than 20%, so that identifying novel diagnostic and prognostic biomarkers is urgently ...
Mengwei Ni, Xinkui Liu, Jiarui Wu, Dan Zhang, Jinhui Tian, Jinhui Tian, Ting Wang, Shuyu Liu, Ziqi Meng, Kaihuan Wang, Xiaojiao Duan, Wei Zhou, Xiaomeng Zhang   +12 more
doaj   +1 more source

Cycloastragenol Derivatives Improve Tyrosine Metabolism, Regulate TLR4/NF‐κB/TERT Signaling Pathways, and Inhibit MPTP Induced Neuroinflammation and PD Symptoms

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Cycloastragenol derivatives regulate the TLR4/NF‐κB/TERT signaling pathway and tyrosine metabolism, breaking the vicious cycle of “inflammation‐aging” and improving symptoms of Parkinson's disease. This study provides direction for the application of natural products in the development of PD drugs.
Shengnan Xiao, Lianmei Liu, Xuemei Qin, Lei Xu, Zhenyu Li, Zhi Chai   +5 more
wiley   +1 more source

Xuetongsu attenuates bone destruction in rheumatoid arthritis by suppressing RANKL/RANK/NFATc1 pathway to inhibit osteoclastogenesis and bone resorption

Bone & Joint Research
Aims: Bone destruction is a pivotal pathological factor in the development of joint disability in rheumatoid arthritis (RA) patients, and there is a paucity of safe and effective drugs targeting bone destruction.
Hao Zheng, Yasi Deng, Bin Li, Juan Huang, Jinzhi Liu, Yupei Yang, Yuxin Chen, Linxi Mao, Yamei Li, Yuexuan Liu, Wei Wang, Huanghe Yu   +11 more
doaj   +1 more source

Multiple Glacial Refugia and Complex Postglacial Dynamics of Primula sikkimensis (Primuaceae) in the Heterogeneous Qinghai‐Tibet Plateau

Ecology and Evolution, Volume 16, Issue 2, February 2026.
Primula sikkimensis persisted in distinct glacial refugia within the Hengduan Mountains and eastern Himalayas during the Last Glacial Maximum. Subsequent postglacial range expansions onto the Qinghai–Tibet Plateau were accompanied by secondary contact and interspecific hybridization, collectively enhancing genetic diversity and adaptive capacity. These
Hua‐Ying Sun, Yu‐Ting He, Zhi‐Hua Zeng, Yuan‐Mi Wu, Li Zhong, Qing‐Hong Feng, Hui‐Ying Gong, Xin Wang, Hong Wang, Zhi‐Kun Wu, Wei Zhou   +10 more
wiley   +1 more source

TPP-related mitochondrial targeting copper (II) complex induces p53-dependent apoptosis in hepatoma cells through ROS-mediated activation of Drp1

Cell Communication and Signaling, 2019
Background In recent years, copper complexes have gradually become the focus of potential anticancer drugs due to their available redox properties and low toxicity. In this study, a novel mitochondrion-targeting copper (II) complex, [Cu (ttpy-tpp)Br2] Br
Jiangjuan Shao, Mengmeng Li, Zijian Guo, Chun Jin, Feng Zhang, Chunyan Ou, Yaochen Xie, Shanzhong Tan, Zhenyi Wang, Shizhong Zheng, Xiaoyong Wang   +10 more
doaj   +1 more source

Artemisia selengensis Leaves, a Vegetable Waste: LC‐MS‐Based Chemical Profiling, Ultrasound‐Assisted DES Extraction, and Xanthine Oxidase Inhibitory Activity

eFood, Volume 7, Issue 1, February 2026.
This study focused on Artemisia selengensis leaves (ASL), a discarded agricultural waste. 72 compounds were identified by UPLC‐Q‐TOF‐MS. “Green” extraction with DES was optimized, and ASL's XO—inhibition was explored, presenting new ways for waste utilization. ABSTRACT Artemisia selengensis is a medicinal and edible plant, whose tender stems are widely
Lixia Li, Mingqiu Shan, Rongli Qiu, Sheng Yu, Ting Geng, Li Zhang, Xinli Liang, Baoxiang Wu, Facheng Zhang   +8 more
wiley   +1 more source