Results 51 to 60 of about 154,329 (250)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Thermotropic phase transitions in Pb1−xSrx(Al1/3Nb2/3)0.1(Zr0.52Ti0.48)0.9O3 ceramics: Temperature dependent dielectric permittivity and Raman scattering

AIP Advances, 2015
The phase transitions of Pb1−xSrx(Al1/3Nb2/3)0.1(Zr0.52Ti0.48)0.9O3 (Sr-modified PAN-PZT) ceramics with Sr compositions of x = 2%, 5%, 10% and 15% have been investigated using X-ray diffraction (XRD), temperature dependent dielectric permittivity and ...
C. Q. Li, L. Peng, P. Wang, K. Jiang, A. Y. Liu, Z. G. Hu, J. H. Chu   +6 more
doaj   +1 more source

Research progress in high-entropy alloys used in brazing and surface engineering fields

Cailiao gongcheng, 2021
With the improvement of alloy manufacturing level and the complexity of performance requirements, high-entropy alloys (HEAs) have gradually attracted great attention.At present,the research in the field of material processing mainly focuses on brazing ...
LI Hong, HAN Yi, CAO Jian, MARIUSZ Bober, JACEK Senkara   +4 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Hot Deformation Behavior of Fe₄₀Mn₂₀Cr₂₀Ni₂₀ Medium-Entropy Alloy

Metals, 2023
Fe40Mn20Cr20Ni20 medium-entropy alloy (MEA) has a single-phase crystal structure with high strength and good ductility at room temperature. It is important to study the hot deformation behavior for this alloy at a partially recrystallized state for ...
Zhen Wang, Qixin Ma, Zhouzhu Mao, Xikou He, Lei Zhao, Hongyan Che, Junwei Qiao   +6 more
doaj   +1 more source

Phase-field simulations of solidification in binary and ternary systems using a finite element method

, 2004
We present adaptive finite element simulations of dendritic and eutectic solidification in binary and ternary alloys. The computations are based on a recently formulated phase-field model that is especially appropriate for modelling non-isothermal ...
Apel, B. Nestler, Boettinger, D. Danilov, Galenko, Garcke, Hoyt, Hoyt, Karma, Kim, Lewis, Nestler, Warren, Zimmermann   +13 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Solid-phase relations in the FeSe-Ga2Se3-Se system and thermodynamic investigation of the FeGa2Se4 compound and (FeSe)1-х(Ga2Se3)х solid solutions

Chemical Thermodynamics and Thermal Analysis
The iron-gallium chalcogenides are promising materials for application in sustainable energy. This work aimed to investigate the solid-phase relations in the Fe-Ga-Se system in the FeSe-Ga2Se3-Se compositions area and the thermodynamic properties of ...
Faik M. Mammadov, Dunya M. Babanly, Samira Z. Imamaliyeva, Ilaha F. Huseynova, Mykola V. Moroz, Vusala A. Abbasova, Ikhtiyar B. Bakhtiyarly, Mahammad B. Babanly   +7 more
doaj   +1 more source

The low-temperature behavior of the quark-meson model

, 2018
We revisit the phase diagram of strong-interaction matter for the two-flavor quark-meson model using the Functional Renormalization Group. In contrast to standard mean-field calculations, an unusual phase structure is encountered at low temperatures and ...
Schaefer, Bernd-Jochen, Tripolt, Ralf-Arno, von Smekal, Lorenz, Wambach, Jochen   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source