Results 141 to 150 of about 5,411,335 (287)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Thermally induced phase separation

Thermally induced phase separation (TIPS) stands as one of the most widely employed methods for preparing polymeric membranes in industrial and academic settings. This chapter aims to provide comprehensive background information on the TIPS method. First,
Tavajohi, Naser,, Ma, Wenzhong,, Zhou, Zhuang,, Khayet, Mohamed,, Cui, Zhaoliang,   +4 more
core   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy. [PDF]

Adv Sci (Weinh)
Lin Y, Dai M, Dai E, Kang R, Klionsky DJ, Tang D, Sun Y, Lv N, Jiang J.   +8 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Protocol for in vitro phase separation of ARID3B proteins. [PDF]

STAR Protoc
Han W, Li X, Lin J, Pan Y.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers. [PDF]

Adv Sci (Weinh)
Michels JJ, Caria J, Lemke EA.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Phase Separation in Regulation of Autophagy

Frontiers in Cell and Developmental Biology, 2022
Yi Lu, Chunmei Chang
doaj   +1 more source

Correction: From chromosomal protein disorder to chromatin phase separation. [PDF]

Epigenetics Chromatin
Davie JR, Ausió J.
europepmc   +1 more source