Results 141 to 150 of about 753,839 (313)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Effect of alkyl chain length on reversed phase stationary phase for separation of integral membrane protein digests [PDF]
, 2011 Effect of alkyl chain length on reversed phase stationary phase for separation of integral membrane protein ...
梁振 +5 more
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Phase separation of chemokinetic active particles
Communications PhysicsMotility-induced phase separation (MIPS) is a well-studied nonequilibrium collective phenomenon observed in active particles. Recently, there has been growing interest in how coupling the self-propulsion of active particles to chemical degrees of freedom
Euijoon Kwon, Yongjae Oh, Yongjoo Baek
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Numerical analysis of a coupled pair of Cahn-Hilliard equations with non-smooth free energy [PDF]
, 2007 A mathematical analysis has been carried out for a coupled pair of Cahn-Hilliard equations with a double well potential function with infinite walled free energy, which appears in modelling a phase separation on a thin film of binary liquid mixture ...
Sripirom, Pisuttawan
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Modeling study on phase separation in three-component biomacromolecular systems
四川大学学报. 自然科学版The phase separation process of biological macromolecules typically occurs in multi-component systems （three or more components）， and classical binary phase separation theory is insufficient to fully describe phase separation in such multi-component ...
GUO Xiuzhen +3 more
doaj
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Review of centrifugal liquid-liquid chromatography using aqueous two-phase solvent (ATPS) systems: Its scale-up and prospects for the future production of high-value biologics [PDF]
, 2007 The future challenges in bioprocessing include developing new downstream processes for the purification and manufacture of the protein based medicines of the future to relieve the predicted bottleneck being produced by increasingly high titres from ...
Sutherland, I A
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