Results 151 to 160 of about 5,411,335 (287)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Phase-Separation-Induced Porous Hydrogels from Amphiphilic Triblock Copolymer with High Permeability and Mechanical Strength

Porous hydrogels, possessing both high mechanical strength and high permeability, are sought after in energy storage, soft robotics, solar vapor generation, and tissue engineering.
Mengze Lu (14262906), Rui Tan (413058), Taolin Sun (7381373), Hui Wang (30400), Tingjian Chen (152759), Zhenhua Xiao (14262909), Liqun Tang (459229), Zi Liang Wu (1412917), Wei Hong (432102), Fei Liu (21082), Xue-hui Dong (14262912)   +10 more
core   +1 more source

α-Synuclein aggregation landscape from phase separation to neurotoxic intermediates. [PDF]

FEBS Lett
Arino S, Fusco G, De Simone A.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The Effect of Protein Tagging on Aggregation and Phase Separation. [PDF]

J Cell Biochem
Saito H, Sugase K.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A pH-Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti-senescence. [PDF]

Smart Mol
Chen Z, Li J, Bao Y, Wang M, Chen H, Zhang M, Ding L, Wu S, Shen B.   +8 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Putting the Squeeze on Phase Separation

JACS Au, 2021
Carla Fernández-Rico, Tianqi Sai, Alba Sicher, Robert W. Style, Eric R. Dufresne   +4 more
doaj   +1 more source

Diverging Liquid-Liquid Phase Separation Behavior of Different Recombinant Major Ampullate Spidroins. [PDF]

Adv Sci (Weinh)
Schiller T, Hayashi C, Scheibel TR.
europepmc   +1 more source