Results 121 to 130 of about 5,411,335 (287)

Order and Phase Separation in Alloys

CHIMIA, 2001
In an initially homogeneous alloy quenched from high temperature, local ordering and/or phase separation may occur on the way towards thermodynamic equilibrium at a lower temperature.
Gernot Kostorz, Bernd Schönfeld
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Reentrant Phase Separation in Microemulsions [PDF]

Physical Review Letters, 1995
Menes, R., Safran, S., Strey, R.
openaire   +3 more sources

Evaluation of sample preparation approaches and separation parameters in HPLC of plant bioactive compounds

, 2015
Plant bioactive compounds can be defined as secondary plant metabolites produced within the plants besides the primary biosynthetic and metabolic routes.
Isabella Nicoletti, Danilo Corradini, Francesca Orsini, Laura De Gara   +3 more
core  

Investigation of three-liquid-phase extraction systems for the separation of Ti(IV), Fe(III) and Mg(II)

, 2010
Three-liquid-phase extraction system (TES) composed of an organic solvent-rich top phase, a polymer-rich middle phase and a salt-rich bottom phase has been considered to be a promising method of isolation and separation of multi-component. In this paper,
Liangrong Yang, Liu, HZ, Yu, Pinhua, Liu, Huizhou, Xie, Keng, Keng Xie, Zhao, Junmei, Yang, Liangrong, Junmei Zhao, Pinhua Yu, Huizhou Liu   +10 more
core   +1 more source

Modeling study on phase separation in three-component biomacromolecular systems

四川大学学报. 自然科学版
The phase separation process of biological macromolecules typically occurs in multi-component systems （three or more components）， and classical binary phase separation theory is insufficient to fully describe phase separation in such multi-component ...
GUO Xiuzhen, HAN Tuodi, HU Lin, ZHAO Xinjun   +3 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Enzyme-Driven Phase Separation

PRX Life
The formation of polarized signaling domains on cell membranes is a fundamental example of biological pattern formation. While such patterns resemble structures from equilibrium phase separation, they are intrinsically nonequilibrium, driven by energy-consuming enzymatic cycles that switch molecules like phosphoinositides or small GTPases between ...
Andreghetti, Damiano, Braunstein, Alfredo, Dall'Asta, Luca, Gamba, Andrea   +3 more
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source