From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Two phase aqueous extraction of whey proteins in a polyethylene glycol - arabinogalactan system [PDF]
, 2014 The whey protein separation potential of aqueous two-phase systems of arabinogalactan [AG] (Lonza FiberAidTM) and polyethylene glycol [PEG], buffered with 10 mmol/g phosphate or citrate buffer, was studied.
Ng, Timothy +3 more
core
Fabrication of PVDF hollow fiber membranes via integrated phase separation for membrane distillation [PDF]
, 2019 © 2018 Taiwan Institute of Chemical Engineers In this study, polyvinylidene fluoride (PVDF) hollow fibers with interpenetrating network morphologies were fabricated via complex thermally induced phase separation (c-TIPS) by integration of non-solvent ...
Chen, Z. +15 more
core +1 more source
ricePSP: a database of rice phase separation-associated proteins
Genome BiologyMultivalent interactions between proteins with intrinsically disordered regions or prion-like domains can drive liquid–liquid phase separation (LLPS) and form membraneless condensates essential for diverse cellular functions.
Runxin Gao +4 more
doaj +1 more source
Viscoelastic model of phase separation [PDF]
Physical Review E, 1997 We show here a general model of phase separation in isotropic condensed matter, namely, a viscoelastic model. We propose that the bulk mechanical relaxation modulus that has so far been ignored in previous theories plays an important role in viscoelastic phase separation in addition to the shear relaxation modulus.
openaire +2 more sources
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
A simple preparation of stationary phase of alkylamide reversed-phase liquid chromatograph for the separation of basic substances [PDF]
, 2002 A simple preparation process of alkylamide phase for reversed-phase HPLC (RP-HPLC) is described. The process includes aminopropyltrimethoxysilane firstly reacted with octanoyl chloride, then the intermediate was coupled onto porous silica.
Wang, J, Huang, XJ, Liu, XL
core
The electrophoretic membrane contactor: A mass-transfer-based methodology applied to the separation of whey proteins [PDF]
, 2011 In the electrophoretic membrane contactor (EMC), a porous membrane is used to establish a contact across two flowing liquids between which an electrically driven mass transfer takes places.
Roux-de Balmann, Hélène +3 more
core +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
HP1 loses its chromatin clustering and phase separation function across evolution
Nature CommunicationsHeterochromatin protein 1 (HP1) is a multifunctional chromatin-associated protein conserved from fission yeast to mammals. HP1 has been suggested to drive heterochromatin formation via phase separation.
Sanâa Bensaha +8 more
doaj +1 more source