Results 91 to 100 of about 2,249,577 (303)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Phase separation of biomembrane-polyelectrolyte interaction system
Shenzhen Daxue xuebao. Ligong banThis study models the regulatory process of biomacromolecular phase separation facilitated by biological membranes. Utilizing molecular dynamics simulations based on the coarse graining (CG) Martini force field, we investigate the phase separation of ...
HAN Tuodi +3 more
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Phase separation on ricinoleic acid freezing
MATEC Web of Conferences, 2018 Phase separation material essentially influence storage capacity or heat release. Ricinoleic acid is potential to be used as a heat storage material. However, the nature of the phase separation of the material has not been studied yet.
Firman, Hasan Barlian, Anshar Muhammad
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Electronic phase separation in the pyrochlore double-exchange model
, 2010 Electronic phase separation and related inhomogeneity is ubiquitously seen in strongly-correlated systems. A typical example is found between ferromagnetic metal and antiferromagnetic insulator in CMR manganese oxides.
Furukawa, Nobuo, Motome, Yukitoshi
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Phase Separation in Doped Mott Insulators
Physical Review X, 2015 Motivated by the commonplace observation of Mott insulators away from integer filling, we construct a simple thermodynamic argument for phase separation in first-order doping-driven Mott transitions.
Chuck-Hou Yee, Leon Balents
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
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Phase Separation and the Phase Diagram in Cuprates Superconductors
, 2006 We show that the main features of the cuprates superconductors phase diagram can be derived considering the disorder as a key property of these materials.
+8 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
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