Results 121 to 130 of about 87,708 (328)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

RGE effects on new physics searches via gravitational waves

Journal of High Energy Physics
Gravitational wave (GW) observations offer a promising probe of new physics associated with a first-order electroweak phase transition. Precision studies of the Higgs potential, including Fisher matrix analyses, have been extensively conducted in this ...
Katsuya Hashino, Daiki Ueda
doaj   +1 more source

Local susy breaking induced by the GUT phase transition in the early universe [PDF]

, 1983
Costas Kounnas, J. León, M. Quirós
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The bubble wall velocity in local thermal equilibrium and energy budget with full effective potential

Journal of High Energy Physics
We develop a framework based on the full one-loop finite-temperature effective potential model, within which the bubble wall velocity is calculated using the local thermal equilibrium (LTE) approximation, and the kinetic energy fraction K is computed ...
Zongguo Si, Hongxin Wang, Lei Wang, Yang Xiao, Yang Zhang   +4 more
doaj   +1 more source

Quark-hadron phase transition in the early Universe: Isothermal baryon-number fluctuations and primordial nucleosynthesis [PDF]

, 1988
G. M. Fuller, G. J. Mathews, C. R. Alcock   +2 more
openalex   +1 more source

Correction: Phase transitions in the early universe

SciPost Physics Lecture Notes, 2021
Mark Hindmarsh, Marvin Lüben, Johannes Lumma, Martin Pauly   +3 more
openaire   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

The formation of primary galactic nuclei during phase transitions in the early universe [PDF]

, 2001
S. G. Rubin, A. Sakharov, Maxim Khlopov
openalex   +1 more source