FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Phase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection. [PDF]
mBio, 2021 Fernández-Calvet A +15 more
europepmc +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
A 5'-UTR cis-acting RNA element targeted by RNase III is essential for DNA simple sequence repeat-dependent phase variation in Haemophilus influenzae. [PDF]
Nucleic Acids ResRapún-Araiz B +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Mannheimia haemolytica Phase Variation
Mannheimia haemolytica is a key agent in bovine respiratory disease (BRD), driving antibiotic use in feedyard cattle. As a facultative anaerobe commonly found in the upper respiratory tracts of cattle, its role under anaerobic conditions in BRD has not ...
Gregory Harhay
core +1 more source
100+ years of phase variation: the premier bacterial bet-hedging phenomenon. [PDF]
Microbiology (Reading)Bayliss CD, Clark JL, van der Woude MW.
europepmc +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Mycobacterium bovis frd operon phase variation hijacks succinate signaling to drive immunometabolic rewiring and pathogenicity. [PDF]
Nat CommunDong Y +10 more
europepmc +1 more source
The Lexical Effects of Anglo-Scandinavian Linguistic Contact in Old English by Sara M. Pons-Sanz. Turnhout: Brepols, 2013. [PDF]
, 2016 Engelse taalkunde +2 more
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