Results 231 to 240 of about 23,945 (282)

Dopaminergic signaling regulates microglial surveillance and adolescent plasticity in the mouse frontal cortex. [PDF]

Nat Commun
Stowell R, Wang KH.
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Multisystem regulation of reward and addiction: beyond the dopaminergic system. [PDF]

Front Pharmacol
Arias-Carrión O, Ortega-Robles E, Treviño M, Guerra-Crespo M, Manjarrez E, Pöppel E.   +5 more
europepmc   +1 more source

Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi, Sola Al Ghazal, Salem Hannoun, Medhat A. Siddik, Nour M. Najjar, Jim Dagher, Joseph Abboud, Myriam G. Semaan, Samia J. Khoury   +8 more
wiley   +1 more source

Neural circuits and emotional processing in rapid eye movement sleep. [PDF]

Front Psychiatry
Chang LY, Wang YQ, Li Z, Zhang Y, Huang ZL, Yang SR.   +5 more
europepmc   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

The Role of GABA and Its Receptors in Temporal Lobe Epilepsy. [PDF]

Biomolecules
Sperk G, Pirker S.
europepmc   +1 more source

Non-calyceal inputs gate the timing of calyx of Held evoked MNTB output. [PDF]

Commun Biol
Console-Meyer L, Jenzen F, Kladisios N, Felmy F.   +3 more
europepmc   +1 more source

Optogenetic Inhibition of Striatal Parvalbuminergic Interneurons Unmasks Impaired GABA and Adenosine Signaling in DYT1 Knock-In Mice. [PDF]

Int J Mol Sci
Marx J, Becker S, Höfert L, Hochheim I, Helmschrodt C, Dreßler J, Richter A, Schulz A.   +7 more
europepmc   +1 more source

Tonic pain modulates neural correlates of associative phasic pain memories. [PDF]

Pain
Hewitt D, Tong S, Schreiber S, Seymour B.   +3 more
europepmc   +1 more source