Results 81 to 90 of about 23,945 (282)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity. [PDF]

, 2015
GABA transporters control extracellular GABA, which regulates the key aspects of neuronal and network behaviour. A prevailing view is that modest neuronal depolarization results in GABA transporter type-1 (GAT-1) reversal causing non-vesicular GABA ...
Rusakov, Dmitri A., Walker, MC, Savtchenko, L, Pavlov, I, Megalogeni, M, Walker, Matthew C., Rusakov, DA, Savtchenko, Leonid, Pavlov, Ivan, Megalogeni, Maria   +9 more
core   +1 more source

Coexistence of lateral and co-tuned inhibitory configurations in cortical networks. [PDF]

PLoS Computational Biology, 2011
The responses of neurons in sensory cortex depend on the summation of excitatory and inhibitory synaptic inputs. How the excitatory and inhibitory inputs scale with stimulus depends on the network architecture, which ranges from the lateral inhibitory ...
Robert B Levy, Alex D Reyes
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Developmental Disruption of GABA_AR-Meditated Inhibition in Cntnap2 KO Mice [PDF]

, 2017
GABA released from presynaptic sites induces short-lived phasic inhibition mediated by synaptic GABAAreceptors (GABAARs) and longer-duration tonic inhibition mediated by extrasynaptic GABAAor GABABreceptors (GABABRs).
Su Mi Park, Shiyong Huang, Morgan S. Bridi   +2 more
core   +1 more source

Releasing dentate nucleus cells from Purkinje cell inhibition generates output from the cerebrocerebellum. [PDF]

PLoS ONE, 2014
The cerebellum generates its vast amount of output to the cerebral cortex through the dentate nucleus (DN) that is essential for precise limb movements in primates.
Takahiro Ishikawa, Saeka Tomatsu, Yoshiaki Tsunoda, Jongho Lee, Donna S Hoffman, Shinji Kakei   +5 more
doaj   +1 more source

Long-latency afferent inhibition during phasic finger movement in focal hand dystonia [PDF]

Experimental Brain Research, 2008
In the motor system, one specific movement is generated, and, simultaneously, other possible movements are suppressed; a process called surround inhibition. Focal hand dystonia (FHD) is a movement disorder characterized by a loss of surround inhibition.
Sarah, Pirio Richardson, Barbara, Bliem, Bernhard, Voller, Nguyet, Dang, Mark, Hallett   +4 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source