Results 61 to 70 of about 23,945 (282)
The generation of antiphase oscillations and synchrony by a rebound-based vertebrate central pattern generator [PDF]
, 2014 Many neural circuits are capable of generating multiple stereotyped outputs after different sensory inputs or neuromodulation.We have previously identified the central pattern generator (CPG) forXenopustadpole swimming that involves antiphase ...
Borisyuk, R +7 more
core +1 more source
Journal of Pharmacological Sciences, 2017 To understand the synaptic and/or extrasynaptic mechanisms underlying pain relief by blockade of glycine transporter subtypes GlyT1 and GlyT2, whole-cell recordings were made from dorsal horn neurons in spinal slices from adult mice, and the effects of ...
Misa Oyama +4 more
doaj +1 more source
The Interplay Between Tonic and Phasic Pupil Activity and Cognitive Flexibility and Stability. [PDF]
PsychophysiologyPrevious research has shown that while larger phasic pupillary activity indexes lower switch costs and better performance on a Stroop task, greater tonic pupillary activity indexes greater exploration.
Jos AM, Westbrook A, LoParco S, Otto AR.
europepmc +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Scientific Reports, 2022 Impairment of cognitive performance is often observed in time-on tasks. Theoretical considerations suggest that especially prefrontal cortex cognitive control functions is affected by time-on-task effects, but the role of effort/task engagement is not ...
Shijing Yu +2 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Neurobiology of Disease, 2023 Evidence suggests that inhibition of α/β hydrolase-domain containing 6 (ABHD6) reduces seizures; however, the molecular mechanism of this therapeutic response remains unknown.
Ruth Westenbroek +3 more
doaj +1 more source
Galanin Inhibits Continuous and Phasic Firing in Rat Hypothalamic Magnocellular Neurosecretory Cells [PDF]
The Journal of Neuroscience, 1997 The effects of galanin (GAL) on magnocellular neurosecretory cells (MNCs) were examined during microelectrode recordings from supraoptic neurons in superfused hypothalamic explants. Application of the full-length peptide (GAL1-29) or of the N-terminal fragment GAL1-16 produced reversible membrane hyperpolarization with an IC50 near 10 nM. These effects
S, Papas, C W, Bourque
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Tonic and phasic nitric oxide signals in hippocampal long-term potentiation [PDF]
, 2006 Nitric oxide ( NO) participates in long-term potentiation (LTP) and other forms of synaptic plasticity in many different brain areas but where it comes from and how it acts remain controversial.
Hopper, RA, Garthwaite, J
core